Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.4.99.6 (
sialyltransferase
)
1,546
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The distribution of alpha 2,3-sialyltransferase (
alpha 2,3-ST
) mRNA in the rat iris and ciliary body was investigated with in situ hybridization histochemistry. Strong expression of
alpha 2,3-ST
mRNA was detected in the inner epithelial layer of the ciliary body and weak expression in the iris epithelium. Since the synthesis of sialoglycoconjugates is completed by terminal sialylation by the action of
sialyltransferase
(ST), the ST-expressed portions are considered to produce sialoglycoconjugates. Hence, the source of the sialoglycoconjugates found in the inner epithelial layer of the ciliary body in previous histochemical studies is the same epithelial cell.
...
PMID:[Distribution of alpha 2,3-sialyltransferase mRNA in rat iris and ciliary body]. 774 Oct 50
We have previously demonstrated that chronic ethanol specifically decreases the hepatic level and rate of synthesis of 2,6-
sialyltransferase
(2,6-ST). To understand its mechanism of action, effects of 8 weeks of chronic ethanol feeding on the expression of
sialyltransferase
(ST) genes in rat liver and kidneys were determined by Northern-blot analysis of ST mRNAs. It was found that, compared with the pair-fed control rats, the percentage decreases in ST mRNAs in the ethanol-fed group were as follows: liver-Gal-beta-1,4GlcNAc alpha 2,6-ST (2,6-ST): 59% (p < 0.001); liver-Gal-beta-1,3GlcNAc
alpha 2,3-ST
(2,3-ST): 32% (p < 0.01); and kidneys-2,6-ST: 5% (NS). In contrast, glyceral-dehyde-3-phosphate dehydrogenase mRNA in both liver and kidneys was unaffected by the same ethanol treatment. Taken together, these results demonstrate that chronic ethanol downregulates the expression of 2,6-ST and 2,3-ST genes in rat liver.
...
PMID:Chronic ethanol downregulates Gal-beta-1,4GlcNAc alpha 2,6-sialyltransferase and Gal-beta-1,3GlcNAc alpha 2,3-sialyltransferase mRNAs in rat liver. 911 74
