Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.4.99.6 (
sialyltransferase
)
1,546
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To investigate the direct effect of glucocorticoids on sialylation of intestinal brush-border hydrolases, explants of fetal and suckling rat intestine were maintained in serum-free or serum-containing organ culture with or without dexamethasone (Dx). Glucoamylase and dipeptidyl peptidase IV developed in organ culture from 18-day-old fetuses persisted in highly sialylated forms for 8 days irrespective of Dx presence, parallel in vivo development leading to less sialylated forms at the age of 6 days. In postnatal cultures the Dx-stimulated
glucoamylase
appeared in a new highly sialylated form never seen after the hormone application in vivo. These findings are in agreement with the elevation of bound
sialyltransferase
(ST) of cultured intestine in protein-free media. In serum-containing medium Dx stimulated the formation and release of soluble ST into the culture medium.
...
PMID:Regulation of sialylation of intestinal brush-border enzymes and of sialyltransferase activity in organ cultures by dexamethasone. 207 6
