Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.4.99.6 (
sialyltransferase
)
1,546
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Spinal cord microglia contribute to nerve injury-induced neuropathic pain. We have previously demonstrated that
toll-like receptor 2
(
TLR2
) signaling is critical for nerve injury-induced activation of spinal cord microglia, but the responsible endogenous
TLR2
agonist has not been identified. Here, we show that nerve injury-induced upregulation of
sialyltransferase
St3gal2 in sensory neurons leads to an increase in expression of the sialylated glycosphingolipid, GT1b. GT1b ganglioside is axonally transported to the spinal cord dorsal horn and contributes to characteristics of neuropathic pain such as mechanical and thermal hypersensitivity. Spinal cord GT1b functions as an
TLR2
agonist and induces proinflammatory microglia activation and central sensitization. Pharmacological inhibition of GT1b synthesis attenuates nerve injury-induced spinal cord microglia activation and pain hypersensitivity. Thus, the St3gal2-GT1b-
TLR2
axis may offer a novel therapeutic target for the treatment of neuropathic pain.
...
PMID:GT1b functions as a novel endogenous agonist of toll-like receptor 2 inducing neuropathic pain. 3203 Aug 4
