Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.4.99.6 (
sialyltransferase
)
1,546
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
This study was conducted to investigate the sialylations of glycoproteins in the nasal glands of patients with
chronic sinusitis
. Sialic acids were detected using lectin histochemistry, and the mRNA of
sialyltransferase
was evaluated by in situ hybridization histochemistry. Sambucus nigra agglutinin (SNA), which recognizes terminal sialic acids, strongly stained the glandular mucous cells of normal subjects, but not those of patients with
chronic sinusitis
. In situ hybridization histochemistry showed that the expression of alpha2,6
sialyltransferase
mRNA was decreased in the secretory cells of patients with
chronic sinusitis
. Our present results suggest that a reduction in
sialyltransferase
activity at the mRNA level in the nasal glands may lead to the persistence of
chronic sinusitis
.
...
PMID:Reduced sialylation of glycoproteins in nasal glands of patients with chronic sinusitis. 919 29
