Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.4.99.6 (
sialyltransferase
)
1,546
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The glycoconjugates of
seborrheic keratosis
in the eyelids were examined by in situ hybridization histochemistry using cRNA probes for
sialyltransferase
(ST) and lectin histochemistry. We considered that the cells, which expressed both cytoplasmic distribution of ST-mRNA and binding of lectins specific for sialic acids to the cell surfaces, were actively producing sialoglycans. We also considered that the cells whose surfaces were stained with the lectins without cytoplasmic distribution of ST-mRNA have completed the synthesis of sialoglycans. These viewpoints suggest that the O-linked sialoglycan, whose turnover-rate is slow, may be distributed over the cells of the thickened spinocellular layer in the tumor of
seborrheic keratosis
and involved in its pathomechanism. It also appears that the turnover rate of the terminal sialic acids in the N-linked glycan in the spinocellular layer may be fast.
...
PMID:[Glycohistochemical analysis of seborrheic keratosis in eyelids]. 917 Aug 50
