Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.4.99.6 (sialyltransferase)
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The binding sites of the anti-cytosolic sialidase antibody and Maackia amurensis lectin II (MAL II: specific for sialic acid alpha 2, 3 galactose) in the epithelium of the rat cornea and conjunctiva were immunohistochemically and lectin-histochemically examined, respectively. Cytosolic sialidase was detected in the cytoplasm of the middle and basal epithelium of the cornea and conjunctiva, whereas MAL II bound to the apical region of their epithelium and the mucous of the goblet cells. The predominant action of the cytosolic sialidase, which is stronger than that of the sialyltransferase, may inhibit the terminal sialylation of the glycoconjugates at the middle and basal regions of the epithelium of the cornea and conjunctiva.
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PMID:[Immunohistochemical localization of cytosolic sialidase in the epithelium of rat cornea and conjunctiva]. 931 Dec 29