Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.4.2.8 (hypoxanthine-guanine phosphoribosyltransferase)
 2,527 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
hypoxanthine-guanine phosphoribosyltransferase 1475
HPRT 1096
Mol 315
AMP 205
Sep 193
X-linked 163
IMP 113
purine nucleoside phosphorylase 76
thymidine kinase 74
GMP 73
HAT 61
ATP 58
X-chromosome 57
adenosine deaminase 57
fused 56
GTP 53
adenosine kinase 51
housekeeping 50
glucose-6-phosphate dehydrogenase 50
G6PD 47
phosphoglycerate kinase 45
PGK 40
p53 40
GAPDH 39
xanthine oxidase 33
5'-nucleotidase 27
X-linked recessive 26
ATPase 26
ACTB 23
hemoglobin 21
beta-actin 20
SDHA 20
NAD 19
lymphoid 18
glyceraldehyde-3-phosphate dehydrogenase 17
cytokine 17
Gen 17
B2M 16
hypoxanthine guanine phosphoribosyltransferase 16
polypeptide 15
endonuclease 15
cytochrome P450 15
telomeric 14
amidophosphoribosyltransferase 14
IFN-gamma 14
erythroid 13
promyelocytic leukemia 13
TBP 13
c-myc 12
T cell receptor 12
glycophorin A 12
ADP 12
guanine deaminase 12
adenylosuccinate synthetase 12
CYP1A1 12
YWHAZ 12
AMP deaminase 12
alpha-galactosidase 11
IL-10 11
ras 11
DNA polymerase 11
PGK1 11
IL-4 10
insulin 10
beta-globin 10
superoxide dismutase 10
thymus 10
GSTM1 10
HMBS 10
interferon 10
CD4 10
hMSH2 9
PPIA 9
p21 9
IFN 9
deoxycytidine kinase 9
Adenosine deaminase 9
HLA 9
adenylosuccinate lyase 9
oxidoreductase 9
more...
Disease
Lesch-Nyhan syndrome 297
cancer 261
tumor 103
carcinogenesis 91
hyperuricemia 71
gout 56
leukemia 51
mental retardation 40
mental retardation 40
lymphoma 40
carcinoma 29
hepatocellular carcinoma 26
arthritis 25
neuroblastoma 24
choreoathetosis 21
xeroderma pigmentosum 20
enzyme deficiency 19
immunodeficiency 18
self-injurious behavior 17
acute promyelocytic leukemia 17
acute lymphoblastic leukemia 15
renal failure 15
anemia 15
lung cancer 14
HIV 14
breast cancer 14
tumorigenesis 13
Schistosoma mansoni 13
fibrosarcoma 12
herpes simplex 12
infectious diseases 12
Fanconi 12
Epstein 12
genetic disorder 11
nephrolithiasis 11
renal disease 10
CEM 10
neoplastic transformation 10
embryonal carcinoma 10
chronic myeloid leukemia 10
melanoma 10
acute myeloid leukemia 10
vaccinia 9
ATM 8
malaria 8
Alzheimer's disease 8
neurological disease 8
colon cancer 8
acute renal failure 8
tumor progression 8
SDS 7
MCF 7
multiple myeloma 7
tuberculosis 7
blast crisis 7
GSH 7
lung carcinoma 7
STS 7
Infection 7
Mycobacterium 7
ADA deficiency 6
Leukemia 6
inflammatory bowel disease 6
Chagas 6
developmental delay 6
diabetes 6
myelodysplastic syndrome 6
adenocarcinoma 6
depression 6
renal insufficiency 5
PNP deficiency 5
fragile X syndrome 5
mantle cell lymphoma 5
Down syndrome 5
virus infection 5
cerebral palsy 5
BLM 5
colorectal cancer 5
MCL 5
skin cancer 5
more...
Symptom
spasticity 18
dystonia 12
starvation 9
seizures 5
hypotonia 3
vomiting 3
weakness 2
dysarthria 2
clumsiness 2
athetosis 2
chorea 2
pain 2
HSA 2
fatigue 2
diarrhea 1
Ill 1
anorexia 1
nausea 1
colic 1
abdominal pain 1
respiratory distress 1
flank pain 1
renal colic 1
ataxia 1
anesthesia 1
constipation 1
dysuria 1
oliguria 1
tremor 1
chromosome marker 1
hepatomegaly 1
Drug
Mutagen 57
G418 22
lysine 15
IFN-gamma 14
DNase I 9
Adenosine deaminase 9
AZT 8
BH4 8
AZT 8
IL-2 7
caffeine 7
Adriamycin 4
ascorbate 4
Thioguanine 4
IFN-beta 4
BLM 3
Dermatol 3
Mycophenolic acid 3
TAT 3
THF 3
-deoxyadenosine 3
Gel 3
MRC 3
vitamin E 3
Nephron 2
nitroglycerin 2
OTC 2
NADH 2
Acyclovir 2
CSF 2
Asn 2
Lead acetate 2
ddI 2
EPA 2
AGG 2
ETS 2
Deoxyadenosine 2
OTC 2
EPI 2
Neocarzinostatin 2
DMAP 2
ACT 2
8-Azaguanine 2
ampicillin 1
Epivir 1
ETA 1
Azithromycin 1
Etoposide 1
6-Methylpurine 1
Infliximab 1
FLP 1
FAD 1
Proflavin 1
Infliximab 1
Arsenic trioxide 1
Glycerol 1
Hypaque 1
Parkin 1
Hypaque 1
CTT 1
Helium 1
PCB 1
Nitric Oxide 1
KCL 1
Prednisone 1
Oxaliplatin 1
ABC 1
Meth 1
Cellcept 1
Glutathione 1
MEA 1
CFX 1
Ouabain 1
TEL 1
Ganciclovir 1
Rasburicase 1
CTX 1
OMP 1
AraC 1
TMX 1
more...
Enzyme
hypoxanthine-guanine phosphoribosyltransferase 2527
adenine phosphoribosyltransferase 179
phosphoglycerate kinase 81
purine nucleoside phosphorylase 76
thymidine kinase 74
adenosine deaminase 59
adenosine deaminase 57
glucose-6-phosphate dehydrogenase 54
glyceraldehyde-3-phosphate dehydrogenase 51
adenosine kinase 47
xanthine oxidase 31
5'-nucleotidase 31
IMP dehydrogenase 30
ATPase 27
PRPP synthetase 26
xanthine phosphoribosyltransferase 25
glyceraldehyde-3-phosphate dehydrogenase 24
glyceraldehyde-3-phosphate dehydrogenase 18
amidophosphoribosyltransferase 18
glyceraldehyde-3-phosphate dehydrogenase 17
glyceraldehyde-3-phosphate dehydrogenase 17
AMP deaminase 16
endonuclease 15
reverse transcriptase 15
adenylosuccinate synthetase 14
orotate phosphoribosyltransferase 13
dihydrofolate reductase 13
DNA polymerase 13
ERK 12
superoxide dismutase 12
deaminase 12
alpha-galactosidase 12
guanase 12
adenine deaminase 11
RNA polymerase 11
glutathione S-transferase 11
catalase 11
adenylosuccinate lyase 10
beta-galactosidase 10
aldehyde dehydrogenase 9
protein kinase 8
trypsin 8
thymidylate synthase 8
alkaline phosphatase 8
deoxycytidine kinase 8
phosphorylase 7
adenylate kinase 7
GMP synthetase 7
alanine aminotransferase 7
topoisomerase 7
focal adhesion kinase 6
deoxyribonuclease 6
chloramphenicol acetyltransferase 6
S1 nuclease 6
porphobilinogen deaminase 6
topoisomerase 6
malate dehydrogenase 6
PARP 6
peroxidase 6
orotidine-5'-phosphate decarboxylase 5
xanthine dehydrogenase 5
GMP reductase 5
PAH 5
deoxyguanosine kinase 5
deoxyadenosine kinase 5
transcriptase 5
DNA ligase 4
DNA ligase 4
CYP3A4 4
AMPK 4
tyrosinase 4
lactate dehydrogenase 4
PRT 4
isocitrate dehydrogenase 4
RNase 4
pyruvate kinase 4
P-glycoprotein 4
monoamine oxidase 4
inosine kinase 4
cytidine deaminase 4
more...
Compound
DNA 806
Dec 191
IMP 116
GMP 94
Clin 80
pyrene 61
phosphate 59
pyrimidine 59
pyrimidine 59
ATP 58
AMP 58
GTP 55
sodium 51
oxygen 50
Hypoxanthine 41
EMS 32
arginine 28
Purine 27
water 26
lysine 22
His 20
NAD 20
acetate 19
NAD 19
hydrogen 18
nitrogen 18
uridine 17
glucose 17
methyl methanesulfonate 16
DMSO 16
retinoic acid 16
methionine 15
calcium 15
Guo 15
adenylate 15
DEAE 14
sulfate 14
Ile 13
serine 13
valine 13
TBP 13
TBP 13
dGTP 13
glutamine 13
nitric oxide 13
pyridine 12
ADP 12
tyrosine 12
Adenine 12
leucine 12
6-Thioguanine 12
Adenine 12
ADP 12
ADP 12
alanine 11
cysteine 11
aldehyde 11
PRPP 11
Asp 11
Tiazofurin 11
potassium 10
NADP 10
Adenosine 10
HPP 10
MNNG 10
creatinine 10
UTP 10
anthracene 10
Inosine 10
aspartic acid 9
threonine 9
PEG 9
urea 9
SDS 9
aspartic acid 9
GAL 9
Phe 9
aspartic acid 9
bromide 9
cadmium 9
more...