Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:2.4.2.8 (hypoxanthine-guanine phosphoribosyltransferase)
2,527 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein hypoxanthine-guanine phosphoribosyltransferase 1475 HPRT 1096 Mol 315 AMP 205 Sep 193 X-linked 163 IMP 113 purine nucleoside phosphorylase 76 thymidine kinase 74 GMP 73 HAT 61 ATP 58 X-chromosome 57 adenosine deaminase 57 fused 56 GTP 53 adenosine kinase 51 housekeeping 50 glucose-6-phosphate dehydrogenase 50 G6PD 47 phosphoglycerate kinase 45 PGK 40 p53 40 GAPDH 39 xanthine oxidase 33 5'-nucleotidase 27 ATPase 26 X-linked recessive 26 ACTB 23 hemoglobin 21 beta-actin 20 SDHA 20 NAD 19 lymphoid 18 glyceraldehyde-3-phosphate dehydrogenase 17 Gen 17 cytokine 17 hypoxanthine guanine phosphoribosyltransferase 16 B2M 16 polypeptide 15 cytochrome P450 15 endonuclease 15 telomeric 14 IFN-gamma 14 amidophosphoribosyltransferase 14 TBP 13 promyelocytic leukemia 13 erythroid 13 adenylosuccinate synthetase 12 YWHAZ 12 guanine deaminase 12 c-myc 12 CYP1A1 12 ADP 12 glycophorin A 12 AMP deaminase 12 T cell receptor 12 PGK1 11 DNA polymerase 11 alpha-galactosidase 11 IL-10 11 ras 11 interferon 10 CD4 10 IL-4 10 superoxide dismutase 10 HMBS 10 beta-globin 10 insulin 10 thymus 10 GSTM1 10 Adenosine deaminase 9 deoxycytidine kinase 9 hMSH2 9 p21 9 adenylosuccinate lyase 9 oxidoreductase 9 HLA 9 FISH 9 IFN 9 PPIA 9 DNase I 9 alkaline phosphatase 8 CD8 8 tRNA 8 microsomal 8 catalase 8 ADA 8 XMP 8 glutathione S-transferase 8 dihydrofolate reductase 8 beta-glucuronidase 8 GSTT1 8 AHH 8 NADP 7 GDP 7 SOD 7 IL-6 7 adenylate kinase 7 NAT2 7 hMLH1 7 p160 7 nucleoside phosphorylase 7 interleukin-2 7 LDHA 7 androgen receptor 7 GSH 7 cryptic 7 proliferating cell nuclear antigen 7 anonymous 7 IMPDH 7 SDS 7 LPS 6 IL-8 6 TGF-beta 6 GPT 6 Met 6 H2AX 6 NMR 6 IL-2 6 cell surface antigen 6 PNP 6 ubiquitin 6 UBC 6 GLA 6 GPI 6 epidermal growth factor 6 phosphorylating 6 MSV 6 surface antigen 6 lectin 6 Polymerase 6 interleukin 2 6 threonine 6 CYP1A2 6 STS 6 IL-1 6 glyceraldehyde 3-phosphate dehydrogenase 6 GMP reductase 5 TK1 5 albumin 5 LDHB 5 ERCC1 5 aprt 5 metallothionein 5 GST 5 transferrin receptor 5 xanthine dehydrogenase 5 TNF 5 PAH 5 HLA-A 5 DHFR 5 CTP 5 p22 5 MCL 5 beta-2-microglobulin 5 growth hormone 5 cytochrome 5 CO2 5 poly(ADP-ribose) polymerase 5 RPL13A 5 granulocyte 5 glycoprotein 5 amyloid precursor protein 5 P450 5 malate dehydrogenase 5 PGD 5 hPMS2 5 GALA 5 deoxyguanosine kinase 5 pseudogene 5 XPD 5 chemokine 4 AR protein 4 tyrosinase 4 glutamine amidotransferase 4 colon carcinoma 4 MIC 4 Rad 4 ARC 4 factor IX 4 tumour suppressor 4 PHA 4 CYP3A4 4 myosin 4 CAT 4 UPS 4 TCR 4 methylguanine-DNA methyltransferase 4 xenobiotic 4 pyruvate kinase 4 mutant p53 4 DBA 4 heavy chain 4 ANOVA 4 Y chromosome 4 GAA 4 CYP2E1 4 Oct4 4 P19 4 cytidine deaminase 4 inducible nitric oxide synthase 4 GPA 4 tyrosine hydroxylase 4 hMSH3 4 membrane-bound 4 Inosine 5'-monophosphate dehydrogenase 4 histone 4 O6-methylguanine-DNA methyltransferase 4 mer 4 IFN-beta 4 P-glycoprotein 4 TAT 4 guanylate kinase 4 fibronectin 4 D10 4 BRCA1 4 STR 4 VIM 4 lipopolysaccharide 4 C18 3 MRC 3 inosine monophosphate dehydrogenase 3 PPH 3 HEC 3 CA1 3 E14 3 ribosomal protein P0 3 glutathione reductase 3 UV20 3 MIP 3 myc oncogene 3 XRCC1 3 phosphatase 3 NTP 3 mannose phosphate isomerase 3 protectin 3 MDH1 3 aryl hydrocarbon hydroxylase 3 BLM 3 sulfotransferase 3 osteosarcoma 3 lactate dehydrogenase 3 microsomal epoxide hydrolase 3 ZFX 3 BOP 3 DNA repair enzyme 3 AAA 3 TGN 3 ODC 3 OGG1 3 c-Ha-ras 3 hydroxymethylbilane synthase 3 VEGF 3 cyclophilin 3 porphobilinogen deaminase 3 FMR1 3 PGM1 3 PARP 3 methyltransferase 3 Bloom syndrome 3 MLH1 3 OCT4 3 HUGO 3 Thymidine kinase 3 MRX 3 MTX 3 ubiquitin C 3 RPLP0 3 She 3 AML 3 histone deacetylase 3 GM-CSF 3 UTR 3 DNA gyrase 3 CD59 3 LDH 3 galactokinase 3 c-myc mRNA 3 TPA 3 NADP+ 3 A-9 3 thymidylate synthase 3 mutS homolog 6 3 prolactin 3 MSH6 3 Genesis 3 catenin 3 OPRT 3 IL-5 3 ALA 3 myelin basic protein 3 esterase 3 nerve growth factor 3 apolipoprotein B 3 AT3 3 Walker 3 Werner syndrome 3 MSH2 3 GSTP1 3 Tuba 3 nicotinic acid phosphoribosyltransferase 3 proto-oncogene 3 TGR 3 RPL32 3 hypoxanthine phosphoribosyltransferase 1 3 RPL13 3 TFRC 3 ALF 3 RPS7 3 myeloperoxidase 3 cyclophilin A 3 REV1 3 K-ras 3 6-phosphogluconate dehydrogenase 3 hBD-2 3 ATR 3 E.coli 3 TNF-alpha 3 GAL 3 RNA polymerase II 3 methylthioadenosine phosphorylase 3 CD28 3 IgA 3 RNase 3 EC2 3 POLB 3 nitric oxide synthase 3 deoxyribonuclease 3 phosphoribosyl pyrophosphate amidotransferase 3 collagen 3 EF-2 2 ornithine decarboxylase 2 ATP-binding cassette 2 CFTR 2 IDH 2 MGR 2 thyroid hormone 2 PLA 2 IDH1 2 tryptophan hydroxylase 2 RPL17 2 CD43 2 RPS4X 2 alpha 1-antitrypsin 2 CYP1B1 2 chromosome 21 2 Gal 2 SRY 2 brain-derived neurotrophic factor 2 topoisomerase I 2 proteolipid protein 2 DLD 2 peroxidase 2 H-ras 2 alpha-galactosidase A 2 SULT1A1 2 Nrf2 2 NBS1 2 tap 2 ZFY 2 BRCA2 2 MHC 2 HIF-1alpha 2 Cytokine 2 asymmetrical 2 CYP 2 TRAIL 2 CD25 2 cathepsin B 2 PIP 2 RPS9 2 TUBB 2 dihydropyrimidine dehydrogenase 2 MRI 2 beta-tubulin 2 dimeric 2 cyclooxygenase-2 2 epoxide hydrolase 2 lysozyme 2 PIG-A 2 DNA ligase I 2 zinc finger 2 EF1A 2 ribosomal protein 2 N-acetyltransferase 2 lymphotoxin 2 elongation factor 2 2 RNS 2 UMP synthase 2 EPI 2 PC6 2 thymidylate synthetase 2 MAP2 2 PPRibP 2 cytochrome c 2 MRE11 2 ESD 2 MEL 2 tau protein 2 RPL4 2 NQO1 2 DNA helicase 2 IL-1 alpha 2 EPHX1 2 XPF 2 MEH 2 insulin-like growth factor 1 2 uridine phosphorylase 2 CD2 2 adenosine monophosphate deaminase 2 genomic clone 2 FANCA 2 reductase 2 DNA repair protein 2 p13 2 succinate dehydrogenase complex subunit A 2 steroid sulfatase 2 estrogen receptor 2 THC 2 tyrosine kinase 2 multidrug resistance protein 2 2 S-adenosylhomocysteine hydrolase 2 MYC 2 catechol-O-methyltransferase 2 IRP1 2 glial fibrillary acidic protein 2 vascular endothelial growth factor receptor 2 ribonucleotide reductase 2 angiotensin II 2 MECP2 2 ENO2 2 IL-17 2 K14 2 angiotensinogen 2 ATF4 2 lamin B2 2 DNA polymerase-alpha 2 peptidylprolyl isomerase A 2 FMRP 2 DMD 2 neuraminidase 2 all-trans 2 MAP kinase kinase 1 2 PARP-1 2 poly(ADP-ribose) synthetase 2 beta actin 2 ADORA2A 2 MCP-1 2 renin 2 OTC 2 PHI 2 IMPDH2 2 S11 2 cytochrome P450 1A1 2 TOP2 beta 2 lactate dehydrogenase A 2 IDS 2 XPC 2 p65 2 vascular endothelial growth factor 2 keratin 2 MOLT 2 Pol 2 CHL 2 Sp1 2 cAMP-dependent protein kinase 2 pol 2 Ah receptor 2 adenylosuccinate synthase 2 Glyceraldehyde-3-phosphate dehydrogenase 2 WAF1 2 GART 2 phosphodiesterase 2 carbonic anhydrase 2 c-fms 2 ADH3 2 dopa decarboxylase 2 olfactory 2 N-ras 2 SCH 2 thiopurine S-methyltransferase 2 amelogenin 2 TPP 2 p16 2 RPL19 2 RPA 2 GADD45 2 ENO1 2 huntingtin 2 DDP 2 AGAT 2 alpha-fetoprotein 2 phosphoglycerate kinase 1 2 AFP 2 interferon-gamma 2 peroxisome proliferator-activated receptor alpha 2 MT1 2 DNA methyltransferase 2 cytokeratin 2 PAR 2 IVF 2 non-functional 2 ABL 2 interleukin-4 2 GUK1 2 A-I 2 lymphokine 2 von Willebrand factor 2 TPI 2 kit 2 A-T 2 homeobox 2 XPA 2 N-cadherin 2 ITPA 2 flavoprotein 2 TATA box binding protein 2 PKM2 2 CGT 2 GOT1 2 HLA-A2 2 CYP2 2 SN2 2 hOGG1 2 MDM2 2 GMP synthase 2 hairless 2 RAD51 2 DNA-binding protein 2 bcl-2 2 glucocorticoid receptor 2 glutathione peroxidase 2 NOD 2 JNK1 2 GAPD 2 CTP synthetase 2 REV1 protein 2 HLA class I 2 CRH 2 proteasome 2 proximal tubule 2 Glucose-6-phosphate dehydrogenase 2 neuronal nitric oxide synthase 2 EPA 2 HDR 2 PHB 2 isocitrate dehydrogenase 2 breakpoint cluster region 2 NADPH 2 MLC 2 MPI 2 cytochrome P450 2E1 2 NADH 2 THP 2 HBA 2 NEIL2 2 Rett syndrome 2 lamp 2 HBB 2 HM1 2 calmodulin 2 DNA polymerase delta 2 PDE 2 beta-2 microglobulin 2 ACT 2 1A1 2 E12 2 hemophilia A 2 Dicer 2 ornithine transcarbamylase 2 CD20 2 ara 2 6PGD 2 AMPK 2 MSH3 2 inosine triphosphatase 2 PFC 2 tumor necrosis factor 2 UDP-glucuronosyltransferase 2 FOXP2 2 adenylate cyclase 2 LDH-B 2 EGF receptor 2 XIAP 2 GUCY2C 1 3-hydroxyanthranilate 3,4-dioxygenase 1 CASP9 1 Factor VIII 1 CD8B 1 binding peptide 1 C11 1 K79 1 chemokine receptor 1 microtubule-associated protein 1 NSF 1 kallikrein 1 annexin A1 1 MDR/TAP 1 NEMO 1 IDP 1 PLAC1 1 urokinase-type plasminogen activator 1 SARS 1 DAXX 1 IAP 1 transcobalamin II 1 NADP-dependent isocitrate dehydrogenase 1 SLC16A2 1 HPR 1 GATA-4 1 DRD5 1 SVV 1 C-C 1 TATA-binding protein 1 RHOXF1 1 MMP-13 1 Hua 1 ANXA11 1 cycA 1 AIB1 1 haptoglobin 1 DRB1 1 phosphoglycerate dehydrogenase 1 c-fos 1 L1 cell adhesion molecule 1 leucocyte antigen 1 HN2 1 P60 1 HOXB4 1 N-ras oncogene 1 pyrimidine 5'-nucleotidase 1 beta-lyase 1 short form 1 AQP5 1 platelet-derived growth factor 1 PSA2 1 neural cell adhesion molecule 1 phosphatidylinositol 3-kinase 1 LDL receptor 1 more...

Disease Lesch-Nyhan syndrome 297 cancer 261 tumor 103 carcinogenesis 91 hyperuricemia 71 gout 56 leukemia 51 lymphoma 40 mental retardation 40 mental retardation 40 carcinoma 29 hepatocellular carcinoma 26 arthritis 25 neuroblastoma 24 choreoathetosis 21 xeroderma pigmentosum 20 enzyme deficiency 19 immunodeficiency 18 acute promyelocytic leukemia 17 self-injurious behavior 17 anemia 15 renal failure 15 acute lymphoblastic leukemia 15 breast cancer 14 HIV 14 lung cancer 14 Schistosoma mansoni 13 tumorigenesis 13 Fanconi 12 Epstein 12 infectious diseases 12 fibrosarcoma 12 herpes simplex 12 nephrolithiasis 11 genetic disorder 11 renal disease 10 acute myeloid leukemia 10 chronic myeloid leukemia 10 embryonal carcinoma 10 CEM 10 melanoma 10 neoplastic transformation 10 vaccinia 9 ATM 8 neurological disease 8 acute renal failure 8 colon cancer 8 tumor progression 8 Alzheimer's disease 8 malaria 8 blast crisis 7 STS 7 SDS 7 GSH 7 multiple myeloma 7 Mycobacterium 7 tuberculosis 7 lung carcinoma 7 Infection 7 MCF 7 developmental delay 6 diabetes 6 myelodysplastic syndrome 6 Chagas 6 adenocarcinoma 6 Leukemia 6 depression 6 ADA deficiency 6 inflammatory bowel disease 6 fragile X syndrome 5 colorectal cancer 5 BLM 5 skin cancer 5 mantle cell lymphoma 5 MCL 5 cerebral palsy 5 renal insufficiency 5 PNP deficiency 5 virus infection 5 Down syndrome 5 Chlamydia 4 Mycoplasma 4 paroxysmal nocturnal hemoglobinuria 4 Turner syndrome 4 mammary tumor 4 SCID 4 cold 4 chronic lymphocytic leukemia 4 suicide 4 childhood cancer 4 fits 4 AIDS 4 renal cell carcinoma 4 cytomegalovirus 4 chemical carcinogenesis 4 plaque 4 PHA 4 tophi 4 Kelley-Seegmiller syndrome 4 urolithiasis 4 APRT deficiency 4 XPD 4 osteosarcoma 3 chronic lymphocytic leukemia 3 Shope fibroma 3 folate deficiency 3 hemophilia B 3 T-cell lymphoma 3 leukemogenesis 3 erythroleukemia 3 Cockayne syndrome 3 herpes 3 AT3 3 AT3 3 uremia 3 AT3 3 AT3 3 AT3 3 AT3 3 uterus 3 AT3 3 AT3 3 acute leukemia 3 AT3 3 Hodgkin's disease 3 squamous cell carcinoma 3 cognitive impairment 3 Gilbert 3 esophageal cancer 3 cystic fibrosis 3 T-cell acute lymphoblastic leukemia 3 schistosomiasis 3 esophageal cancer 3 epithelial ovarian cancer 3 leishmaniasis 3 malnutrition 3 ovarian cancer 3 rheumatoid arthritis 3 megaloblastic anemia 3 AAA 3 CNS diseases 3 Fanconi syndrome 3 DBA 3 bladder cancer 3 diphtheria 3 APC 3 abdominal aortic aneurysm 3 African trypanosomiasis 3 MIP 3 WRN 3 Duchenne muscular dystrophy 3 West 3 ischemia 3 Placenta 2 mouse leukemia L1210 2 MLC 2 systemic lupus erythematosus 2 Lyme disease 2 Cushing's disease 2 myeloproliferative disorders 2 pulmonary fibrosis 2 Haemophilia 2 prostate cancer 2 refractory anemia 2 stroke 2 renal impairment 2 second cancer 2 tumor growth 2 pheochromocytoma 2 gouty nephropathy 2 thymoma 2 SEM 2 Burkitt's lymphoma 2 relapsing fever 2 childhood ALL 2 panhypopituitarism 2 parkinsonism 2 confusion 2 SCH 2 autoimmune disease 2 retinoblastoma 2 pituitary tumor 2 myeloid leukemia 2 HBB 2 sickle cell disease 2 uricosuria 2 coronary artery disease 2 sarcoma 2 neuroma 2 neutropenia 2 latent infection 2 Robinson 2 acute nonlymphocytic leukemia 2 pneumonia 2 Huntington's disease 2 wasting 2 giardiasis 2 hydrocephalus 2 ABL 2 obesity 2 non-small cell lung cancer 2 EPI 2 Barrett's esophagus 2 HBB 2 HBB 2 HAM 2 IVF 2 dehydration 2 NOD 2 Poland 2 glioblastoma 2 hypertension 2 glioma 2 Dissociation 2 adenoma 2 Klebsiella 2 PDE 2 brain dysfunction 2 haemophilia 2 seminoma 2 DDP 2 atopic dermatitis 2 Spleen 2 self-destructive behavior 2 Ovary 2 failure to thrive 2 preeclampsia 2 type 2 diabetes 2 tetanus 2 spastic diplegia 2 metabolic disorder 2 aggression 2 mild mental retardation 2 incontinentia pigmenti 2 trisomy 2 polyneuropathy 2 Graves' disease 2 influenza 2 skin tumor 2 chronic myeloproliferative disorders 2 Blocking 2 Ovary 2 orotic aciduria 2 endometrial cancer 2 idiopathic thrombocytopenic purpura 2 Wiskott-Aldrich syndrome 2 XPF 2 epilepsy 2 XPG 2 developmental disabilities 2 ureter 1 FBS 1 myelopathy 1 amelanotic melanoma 1 multiple sclerosis 1 lupus 1 blood neoplasm 1 germ cell tumor 1 asthma 1 macrocephaly 1 fibroma 1 heart failure 1 cholangitis 1 muscular dystrophy 1 Borna disease 1 FANCD1 1 small cell lung cancer 1 B-ALL 1 gastrointestinal cancer 1 worms 1 hemangioendothelioma 1 TMD 1 myelosuppression 1 lymphedema 1 myelofibrosis 1 TEM 1 thrombocytopenia 1 testicular cancer 1 temporal lobe epilepsy 1 petechiae 1 pulmonary embolism 1 myositis 1 synovial sarcoma 1 atherosclerosis 1 adult soft tissue sarcoma 1 purpura 1 metastatic melanoma 1 TTP 1 Pancreas 1 histiocytic lymphoma 1 DRD 1 pyometra 1 hepatitis A 1 XPE 1 GCT 1 ICH 1 premature aging 1 salivary gland cancer 1 coccidiosis 1 Fowlpox 1 polyposis 1 endometriosis 1 HOS 1 brucellosis 1 HPRT PARIS 1 Colon 1 secondary AML 1 color blindness 1 hyperargininemia 1 Burkitt-like lymphoma 1 status epilepticus 1 stomatitis 1 sialidosis 1 Deficiency of uracil phosphoribosyltransferase 1 Pancreas 1 multiple endocrine neoplasia 1 ventral hernia 1 tumor angiogenesis 1 Severe sepsis 1 autism 1 SAR 1 RARS 1 ADH 1 malignant state 1 thyroid neoplasm 1 intestinal cancer 1 retinopathy 1 conjunctivitis 1 chronic stable angina 1 interstitial nephritis 1 retinitis pigmentosa 1 interstitial lung disease 1 hepatoblastoma 1 pituitary adenoma 1 nephrocalcinosis 1 Pituitary 1 azotemia 1 compulsion 1 Rett syndrome 1 Brown 1 Neumann 1 CAE 1 AN2 1 aggressiveness 1 PSS 1 Hippel 1 Fabry 1 Lowe 1 L. infantum 1 schwannoma 1 Marek's disease 1 idiopathic dilated cardiomyopathy 1 carcinoid 1 adenomyosis 1 uropathy 1 coronary heart disease 1 chronic myelomonocytic leukemia 1 hereditary motor and sensory neuropathy 1 ARF 1 chronic renal failure 1 Legionella 1 Melanoma 1 measles 1 testicular carcinoma 1 mole 1 plasma cell leukemia 1 gestational trophoblastic disease 1 encephalopathy 1 Hashimoto's thyroiditis 1 sepsis 1 achalasia 1 CAE 1 cryptosporidiosis 1 Schwannoma 1 Schwannoma 1 bacterial infection 1 Giant 1 Cushing's syndrome 1 Hymenolepis 1 aplastic anemia 1 macrocytic anemia 1 multinodular goiter 1 Colon 1 Gouty arthritis 1 MRX46 1 Hyperuricemic nephropathy 1 RBS 1 Appendix 1 sarcoma 180 1 abortion 1 Kaposi's sarcoma 1 NLS 1 hyperinsulinemia 1 Lowe syndrome 1 Bradley 1 subacute sclerosing panencephalitis 1 RP10 1 solid tumor 1 Dandy-Walker malformation 1 deafness 1 TCC 1 Klinefelter's syndrome 1 cutaneous melanoma 1 RTS 1 XX males 1 cardiovascular disease 1 dysphagia 1 CREST 1 basal ganglia disease 1 AGA 1 polyarthritis 1 neurobehavioral problems 1 EMT 1 acromegaly 1 lupus 1 hyperprolactinemia 1 eczema 1 Galactosialidosis 1 SD1 1 NAME 1 dengue 1 Tourette syndrome 1 PSS 1 hyperthyroidism 1 vascular disease 1 FRAXA 1 Parkinson's disease 1 X-linked agammaglobulinemia 1 X-linked hyper-IgM syndrome 1 MAR 1 polycythemia vera 1 CAP 1 thrombocytosis 1 IgA deficiency 1 hypobetalipoproteinemia 1 invasive cancer 1 TTP 1 giant cell arteritis 1 meningioma 1 HML 1 CPL 1 G6PD deficiency 1 HPP 1 Immune thrombocytopenia 1 teratoma 1 trichomoniasis 1 osteoarthritis 1 Adenovirus 1 glycogen storage disease 1 sepsis 1 Adhesion 1 cataract 1 hypogonadotropic hypogonadism 1 meningoencephalomyelitis 1 dermatomyositis 1 Appendix 1 severe mental retardation 1 human papilloma virus 1 affective disorder 1 goiter 1 human papilloma virus 1 abnormal involuntary movements 1 mesothelioma 1 Wright 1 renal cancer 1 Sezary syndrome 1 SARS 1 immunopathology 1 Rous sarcoma 1 primary myelofibrosis 1 agranulocytosis 1 Appendix 1 IBM 1 HPP 1 tubular necrosis 1 infectious mononucleosis 1 chronic granulomatous disease 1 infertility 1 purine metabolism disorder 1 SCS 1 Ewing's sarcoma 1 dysplastic nevi 1 LYP 1 testicular atrophy 1 von Willebrand disease 1 delirium tremens 1 histiocytic lymphoma 1 blindness 1 X-linked lymphoproliferative syndrome 1 AIC 1 sleep apnea 1 leptospirosis 1 PSA 1 uterine cervix 1 CGL1 1 radiation carcinogenesis 1 NBS 1 dissociative disorder 1 Evans 1 progeria 1 familial disorder 1 prolapse 1 degenerative disease 1 anosognosia 1 tapeworm 1 Simpson-Golabi-Behmel syndrome 1 UMP synthase deficiency 1 EBV infection 1 neuropathy 1 movement disorder 1 XP-A 1 environmental carcinogenesis 1 DMS 1 XPB 1 Colon 1 liver cancer 1 MPS II 1 PSS 1 ileus 1

Symptom spasticity 18 dystonia 12 starvation 9 seizures 5 hypotonia 3 vomiting 3 weakness 2 dysarthria 2 clumsiness 2 athetosis 2 chorea 2 pain 2 HSA 2 fatigue 2 diarrhea 1 Ill 1 anorexia 1 nausea 1 colic 1 abdominal pain 1 respiratory distress 1 flank pain 1 renal colic 1 ataxia 1 anesthesia 1 constipation 1 dysuria 1 oliguria 1 tremor 1 chromosome marker 1 hepatomegaly 1

Drug Mutagen 57 G418 22 lysine 15 IFN-gamma 14 DNase I 9 Adenosine deaminase 9 AZT 8 AZT 8 BH4 8 caffeine 7 IL-2 7 ascorbate 4 Adriamycin 4 IFN-beta 4 Thioguanine 4 Mycophenolic acid 3 MRC 3 TAT 3 THF 3 Gel 3 -deoxyadenosine 3 BLM 3 Dermatol 3 vitamin E 3 Acyclovir 2 Nephron 2 OTC 2 EPI 2 NADH 2 ddI 2 AGG 2 Deoxyadenosine 2 CSF 2 EPA 2 ACT 2 Asn 2 Lead acetate 2 nitroglycerin 2 OTC 2 DMAP 2 Neocarzinostatin 2 ETS 2 8-Azaguanine 2 ampicillin 1 Epivir 1 ETA 1 Azithromycin 1 Etoposide 1 6-Methylpurine 1 Infliximab 1 FLP 1 FAD 1 Proflavin 1 Infliximab 1 Arsenic trioxide 1 Glycerol 1 Hypaque 1 Parkin 1 Hypaque 1 Helium 1 Nitric Oxide 1 KCL 1 PCB 1 Spectrum 1 Cellcept 1 Cellcept 1 CaCl2 1 CaCl2 1 MIL 1 CFX 1 Ouabain 1 PTC 1 Febuxostat 1 CTT 1 Vitamin E 1 Propidium 1 Imatinib 1 Oxaliplatin 1 ABC 1 Meth 1 Gleevec 1 AIC 1 AmBisome 1 ICI 1 Prednisone 1 Formycin B 1 MEA 1 Retinoic acid 1 ROS 1 Glutathione 1 Zmax 1 Nephron 1 Rasburicase 1 CTX 1 OMP 1 AraC 1 TMX 1 Ganciclovir 1 Aztec 1 Areca 1 TEL 1 2-Methoxyethanol 1 Dial 1 Cytidine 1 Spectrum 1 CaCl2 1 NH3 1 Alanine 1 Parkin 1

Enzyme hypoxanthine-guanine phosphoribosyltransferase 2527 adenine phosphoribosyltransferase 179 phosphoglycerate kinase 81 purine nucleoside phosphorylase 76 thymidine kinase 74 adenosine deaminase 59 adenosine deaminase 57 glucose-6-phosphate dehydrogenase 54 glyceraldehyde-3-phosphate dehydrogenase 51 adenosine kinase 47 xanthine oxidase 31 5'-nucleotidase 31 IMP dehydrogenase 30 ATPase 27 PRPP synthetase 26 xanthine phosphoribosyltransferase 25 glyceraldehyde-3-phosphate dehydrogenase 24 glyceraldehyde-3-phosphate dehydrogenase 18 amidophosphoribosyltransferase 18 glyceraldehyde-3-phosphate dehydrogenase 17 glyceraldehyde-3-phosphate dehydrogenase 17 AMP deaminase 16 endonuclease 15 reverse transcriptase 15 adenylosuccinate synthetase 14 orotate phosphoribosyltransferase 13 DNA polymerase 13 dihydrofolate reductase 13 alpha-galactosidase 12 superoxide dismutase 12 deaminase 12 ERK 12 guanase 12 glutathione S-transferase 11 adenine deaminase 11 RNA polymerase 11 catalase 11 beta-galactosidase 10 adenylosuccinate lyase 10 aldehyde dehydrogenase 9 trypsin 8 alkaline phosphatase 8 thymidylate synthase 8 protein kinase 8 deoxycytidine kinase 8 GMP synthetase 7 topoisomerase 7 phosphorylase 7 alanine aminotransferase 7 adenylate kinase 7 PARP 6 S1 nuclease 6 malate dehydrogenase 6 peroxidase 6 topoisomerase 6 focal adhesion kinase 6 chloramphenicol acetyltransferase 6 porphobilinogen deaminase 6 deoxyribonuclease 6 GMP reductase 5 transcriptase 5 xanthine dehydrogenase 5 deoxyguanosine kinase 5 orotidine-5'-phosphate decarboxylase 5 deoxyadenosine kinase 5 PAH 5 phosphoglucose isomerase 4 DNA ligase 4 tyrosinase 4 PRT 4 isocitrate dehydrogenase 4 cytidine deaminase 4 P-glycoprotein 4 monoamine oxidase 4 RNase 4 pyruvate kinase 4 lactate dehydrogenase 4 inosine kinase 4 AMPK 4 CYP3A4 4 DNA ligase 4 nucleotidase 4 tyrosine hydroxylase 3 phosphomannose isomerase 3 guanylate kinase 3 mitogen-activated protein kinase 3 ribokinase 3 galactokinase 3 RNase 3 tryptophan hydroxylase 3 AMP-activated protein kinase 3 uracil phosphoribosyltransferase 3 STR 3 6-phosphogluconate dehydrogenase 3 aryl hydrocarbon hydroxylase 3 luciferase 3 ornithine transcarbamylase 3 MIP 3 beta-glucuronidase 3 micrococcal nuclease 3 NQO1 3 complex I 3 6-phosphogluconate dehydrogenase 3 uricase 3 succinate dehydrogenase 3 glutathione reductase 3 methylthioadenosine phosphorylase 3 microsomal epoxide hydrolase 3 thiopurine methyltransferase 3 TAT 3 nicotinic acid phosphoribosyltransferase 3 phosphoenolpyruvate carboxylase 2 Fpg protein 2 glutathione peroxidase 2 soluble epoxide hydrolase 2 lysozyme 2 arylsulfatase 2 UDP-glucuronosyltransferase 2 cyclohydrolase 2 DNA methyltransferase 2 HDR 2 ribonucleotide reductase 2 uridine phosphorylase 2 proteasome 2 cathepsin B 2 NO synthase 2 TPP 2 inosine triphosphatase 2 3'-phosphatase 2 nucleoside phosphotransferase 2 tissue plasminogen activator 2 DNase 2 glycinamide ribonucleotide transformylase 2 AICAR transformylase 2 dihydroorotase 2 neuraminidase 2 adenylate cyclase 2 phenylalanine hydroxylase 2 N-acetyltransferase 2 arginase 2 ADH3 2 carbonic anhydrase 2 renin 2 NADPH oxidase 2 TPP 2 GMP synthase 2 NADPH oxidase 2 dihydropyrimidine dehydrogenase 2 ribonucleotide reductase 2 collagenase 2 isocitrate dehydrogenase 2 phosphodiesterase 2 CGT 2 PDE 2 AMPK 2 CTP synthase 2 S-adenosyl-L-homocysteine hydrolase 2 gamma-glutamyl transpeptidase 2 ornithine decarboxylase 2 DOPA decarboxylase 2 urease 2 PGM 2 IMP cyclohydrolase 1 CPS 1 phosphoglycerate dehydrogenase 1 deoxycytidine deaminase 1 propionyl-CoA carboxylase 1 kallikrein 1 uridine hydrolase 1 nucleoside diphosphokinase 1 adenosine nucleosidase 1 hexokinase 1 sulfatase 1 sialidase 1 propionyl-CoA carboxylase 1 CAD 1 aldehyde dehydrogenase 1 carbonyl reductase 1 acetylcholinesterase 1 phosphatidylinositol 3-kinase 1 aldolase 1 Thy1 1 aldehyde dehydrogenase 1 PKG 1 glucose dehydrogenase 1 protein kinase C 1 formaldehyde dehydrogenase 1 aldehyde dehydrogenase 1 nicotinamide phosphoribosyltransferase 1 CaMKII 1 anthranilate synthase 1 3-hydroxyanthranilic acid oxygenase 1 nicotinamide mononucleotide adenylyltransferase 1 PDK1 1 alanine dehydrogenase 1 tryptophanyl-tRNA synthetase 1 CAD 1 MDH 1 PTPase 1 CAD 1 paraoxonase 1 firefly luciferase 1 GCA 1 PPH 1 proprotein convertase 1 TdT 1 thymidine phosphorylase 1 subtilisin 1 formyltetrahydrofolate deformylase 1 CPL 1 caspase-1 1 proteinase K 1 NMT 1 ADH 1 PIP kinase 1 serine hydroxymethyltransferase 1 LPL 1 NOS 1 MEK 1 polynucleotide phosphorylase 1 phosphoglucomutase 1 prolinase 1 glycerol-3-phosphate dehydrogenase 1 APC 1 CPT 1 dihydropyrimidine dehydrogenase 1 ATP synthase 1 CPT 1 myrosinase 1 ACS 1 urokinase-type plasminogen activator 1 demethylase 1 dihydropyrimidinase 1 peroxiredoxin 1 PRE 1 furin 1 aspartate transcarbamylase 1 methionine adenosyltransferase 1 deoxyribonuclease 1 TSP-1 1 urease 1 aspartokinase 1 CPT 1 dopamine beta-hydroxylase 1 histone demethylase 1 CPR 1 SpeB 1 alanine racemase 1 choline acetyltransferase 1 EC 1.3.2.3 1 aspartate aminotransferase 1 transketolase 1 penicillopepsin 1 NADPH-diaphorase 1 prostaglandin synthetase 1 DHOdehase 1 EC 1.1.1.40 1 GTP cyclohydrolase I 1 dihydrodiol dehydrogenase 1 creatine kinase 1 acid phosphatase 1 AGT 1 squalene epoxidase 1 carboxylesterase 1 enolase 1 tyrosine aminotransferase 1 type III procollagen 1 S-adenosylmethionine decarboxylase 1 elastase 1 paraoxonase 1 alcohol dehydrogenase 1 argininosuccinate synthetase 1 ceruloplasmin 1 glycerol-3-phosphate dehydrogenase 1 glucose oxidase 1 BAL 1 aldehyde dehydrogenase 1 thymidylate kinase 1 CMP kinase 1 meprin 1 peptidyl-prolyl cis-trans isomerase 1 tripeptidase 1 ALDH 1 gluconate dehydrogenase 1 MDH 1 uridine kinase 1 AST 1 lipase 1

Compound DNA 806 Dec 191 IMP 116 GMP 94 Clin 80 pyrene 61 phosphate 59 pyrimidine 59 pyrimidine 59 ATP 58 AMP 58 GTP 55 sodium 51 oxygen 50 Hypoxanthine 41 EMS 32 arginine 28 Purine 27 water 26 lysine 22 His 20 NAD 20 acetate 19 NAD 19 hydrogen 18 nitrogen 18 glucose 17 uridine 17 methyl methanesulfonate 16 retinoic acid 16 DMSO 16 Guo 15 calcium 15 adenylate 15 methionine 15 sulfate 14 DEAE 14 TBP 13 serine 13 Ile 13 dGTP 13 nitric oxide 13 TBP 13 valine 13 glutamine 13 6-Thioguanine 12 ADP 12 Adenine 12 ADP 12 leucine 12 ADP 12 pyridine 12 Adenine 12 tyrosine 12 Tiazofurin 11 PRPP 11 alanine 11 aldehyde 11 Asp 11 cysteine 11 UTP 10 Adenosine 10 Inosine 10 NADP 10 MNNG 10 HPP 10 anthracene 10 potassium 10 creatinine 10 formaldehyde 9 SDS 9 threonine 9 aspartic acid 9 urea 9 bromide 9 aspartic acid 9 GAL 9 PEG 9 aspartic acid 9 Phe 9 cadmium 9 aspartic acid 9 ammonium 8 cAMP 8 6-Mercaptopurine 8 PPi 8 AZT 8 XMP 8 chromium 8 Mg2+ 8 isoleucine 8 Xanthine 8 isoleucine 8 GDP 8 formaldehyde 7 AAF 7 CO2 7 2-hydroxyethyl 7 2-hydroxyethyl 7 2-hydroxyethyl 7 caffeine 7 2-hydroxyethyl 7 2-hydroxyethyl 7 GSH 7 2-hydroxyethyl 7 2-hydroxyethyl 7 2-hydroxyethyl 7 methane 7 aflatoxin B1 7 GSH 7 acrylamide 7 tryptophan 6 Neo 6 aldehyde 6 ethanol 6 silver 6 dATP 6 manganese 6 Guanine 6 acetaldehyde 6 BUdR 6 PNP 6 GPT 6 glucose-6-phosphate 6 dCTP 6 BLM 5 proline 5 H2O2 5 PAH 5 CTP 5 nickel 5 glutamate 5 zinc 5 TNF 5 1,3-Butadiene 5 glutamic acid 5 DDP 5 NH2 5 ammonia 5 methanol 5 acrylonitrile 5 3-aminobenzamide 5 Methotrexate 5 Gly 5 iron 5 Styrene 5 acridine 4 AICAR 4 CAT 4 MDA 4 DBA 4 Guo 4 Cardiol 4 ENU 4 DMS 4 salt 4 PMA 4 TGR 4 benzene 4 Adriamycin 4 TTP 4 MIC 4 3TC 4 NOP 4 MTT 4 CAT 4 galactose 4 Pac 4 CAT 4 HCl 4 glycerol 4 Azan 4 TPA 4 nicotinic acid 4 COS 4 MMC 4 EDTA 3 MTX 3 quinoline 3 TEM 3 PAC 3 boron 3 cobalt 3 pentose 3 nicotinic acid 3 nonyl 3 pentose 3 pentose 3 2-ethylhexyl 3 ABL 3 DBA 3 AAA 3 nitrate 3 Neuronal 3 BOP 3 dGMP 3 acrylonitrile 3 cinnamyl 3 hexose 3 AICAR 3 Ribavirin 3 nicotinic acid 3 gamma-aminobutyric acid 3 pentose 3 Uric acid 3 THP 3 Estrogen 3 2-ethylhexyl 3 Cyt 3 TPA 3 Benzo[a]pyrene 3 2-ethylhexyl 3 asparagine 3 DBA 3 Azathioprine 3 Triton 3 selenium 3 chloroform 3 nicotinamide 3 EDTA 3 homocysteine 3 nicotinic acid 3 quinoline 3 2,2,6,6-tetramethylpiperidine 3 MNU 2 hexose 2 TPP 2 Hydroxyurea 2 DMAP 2 PAR 2 Acyclovir 2 hydroxide 2 hexose 2 DIC 2 THP 2 Thymidine 2 tryptophan 2 HBB 2 tryptophan 2 DBP 2 Carbon 2 Tiron 2 ADP-ribose 2 naphthalene 2 DEHP 2 GGG 2 8-OHdG 2 methyl acrylate 2 NADH 2 Tris 2 NADPH 2 UMP 2 UDP 2 EPA 2 TPP 2 2-methoxyethyl 2 ethyl acrylate 2 WR-1065 2 dUTP 2 Parks 2 PEG 2 pyrrolidine 2 Cyd 2 5-Azacytidine 2 adenylosuccinate 2 Thymine 2 Ochratoxin A 2 HMF 2 Tris 2 GABA 2 ITP 2 Benzidine 2 acetonitrile 2 GABA 2 MSM 2 toluene 2 hydrazine 2 HCP 2 betaine 2 thioglycollate 2 DMD 2 NADPH 2 m-AMSA 2 hydroxyindoleacetic acid 2 BCNU 2 CCC 2 Optimal 2 hexose 2 ribose-5-phosphate 2 1-pyrenol 2 VP-16 2 pyrrolidine 2 tryptophan 2 adenosylmethionine 2 PHB 2 Trenbolone 2 benzamide 2 TPP 2 5-FU 2 MTA 2 retinol 2 mercury 2 DMAP 2 acetic acid 2 MNU 2 Neocarzinostatin 2 2-methoxyethyl 2 dGDP 2 Insulin 2 MgCl2 2 Deoxyadenosine 2 CCC 2 DMAP 2 TAA 1 MPP 1 ACS 1 2,6-DMA 1 TCA 1 hexanal 1 R 48 1 Rapamycin 1 2,5-dichlorophenol 1 d4T 1 40S 1 CTX 1 bromoacetic acid 1 Corticosterone 1 Piper 1 Haloperidol 1 acrylic acid 1 MCA 1 Palmitoleic acid 1 Norepinephrine 1 DCB 1 Hydrazine 1 Tamoxifen 1 PPD 1 Cocaine 1 acetamide 1 Thyroid 1 Dichloroacetate 1 Methylmercuric hydroxide 1 malic acid 1 Ethionine 1 2-imidazolidinone 1 2-methoxyethanol 1 Morin 1 methoxyacetic acid 1 2-ethylhexyl acrylate 1 Bisulfite 1 N-ethylurea 1 benzo[ghi]perylene 1 DMA 1 perchloric acid 1 GA1 1 MGBG 1 SC-1 1 Glutamate 1 Alanine 1 Filipin 1 Nitroglycerin 1 Testosterone 1 GA2 1 Titanium dioxide 1 Formycin B 1 BAL 1 TRH 1 3-methylindole 1 Serine 1 HN2 1 MOCA 1 TCC 1 Coformycin 1 Steviol 1 phosphorus 1 Bisphenol A 1 D-glucuronate 1 6-Ethylmercaptopurine 1 noradrenaline 1 alpha-Naphthoflavone 1 R 7000 1 Marmesin 1 Ribose 1 ornithine 1 Glycidyl methacrylate 1 Cobalt 1 ACS 1 PGE2 1 Dopamine 1 Myosmine 1 naphthoquinone 1 CAP 1 Ascorbic acid 1 STZ 1 1,2-butanediol 1 ETA 1 Perillaldehyde 1 COX 1 NIDA 1 hydroxylamine 1 DHA 1 Formycin B 1 Angelicin 1 2-butanone 1 Belt 1 Ciprofloxacin 1 tin 1 O6-Methylguanine 1 diacetate 1 Quercetin 1 3-methoxybenzamide 1 Testosterone 1 Geigy 1 HEI 1 Diazepam 1 chrysene 1 Acivicin 1 HIS 1 PEI 1 DEA 1 Malate 1 PLP 1 L-DOPA 1 lauric acid 1 copper 1 C10H12N4O5S 1 PPD 1 Vanillin 1 Camptothecin 1 2,5-DCP 1 4-vinylbenzoic acid 1 Prednisone 1 Cortisone 1 PHE 1 chloroacetic acid 1 Diepoxybutane 1 hexane 1 SC-1 1 alpha-Naphthoflavone 1 DHA 1 HBA 1 phenanthrene 1 IDP 1 hexanal 1 hydroxylamine 1 Uridine 1 6-Methylpurine 1 HEPES 1 MOD 1 VM-26 1 NMA 1 DMPC 1 Bisphenol A 1 piperidine 1 TDI 1 Vitamin E 1 Guanidinoacetic acid 1 butanal 1 ECP 1 BSH 1 methylhistamine 1 ASC 1 Camptothecin 1 vinyl acetate 1 4-Aminobiphenyl 1 MGBG 1 Deoxyguanosine 1 CI-921 1 4-methoxybenzyl 1 DMA 1 5H-pyrido[4,3-b]indole 1 Diacetyl 1 Coumarin 1 alpha-Naphthoflavone 1 vinyl 1 DCB 1 Novobiocin 1 Radium-224 1 MEP 1 HBr 1 ornithine 1 DON 1 ornithine 1 phenazine 1 G20 1 1-methylhistidine 1 DEA 1 Acrolein 1 ornithine 1 pentanal 1 Dial 1 xylose 1 methoxyacetaldehyde 1 Wortmannin 1 4-Hydroxynonenal 1 MOP 1 dichloromethane 1 sulfuric acid 1 7H-dibenzo[c,g]carbazole 1 formamide 1 DCB 1 3-methylhistidine 1 CPT 1 Ethylene oxide 1 Glucosamine 1 T11 1 Hypaque 1 acetamide 1 Orotidine 1 Tocopherols 1 N-acetylcysteine 1 fMet 1 phenol 1 C5H5NO 1 C7H8N4S 1 DCB 1 vinyl laurate 1 4-nitrophenyl 1 boric acid 1 benzo[a]anthracene 1 AIR 1 A 3 1 PDB 1 Inosinic acid 1 4-NQO 1 MEA 1 5-Methylcytosine 1 cyclohexanone 1 ICI 1 DCM 1 CaCl2 1 ECP 1 chromate 1 L-leucine 1 DHA 1 FAD 1 CAM 1 SCC 1 Camptothecin 1 Radon-222 1 SPM 1 S-adenosylhomocysteine 1 indole-3-carbinol 1 CPT 1 CAP 1 6-Mercaptopurine riboside 1 D-glucosamine 1 Glutaraldehyde 1 Xanthosine 1 ECP 1 methylphosphonic acid 1 ETH 1 Marmesin 1 Flux 1 Domoic acid 1 Ifosfamide 1 methylphosphonic acid 1 L-T3 1 Arsenite 1 2-hexenal 1 Methylene blue 1 piperidine 1 ornithine 1 Curcumin 1 1,6-Dinitropyrene 1 cyclopentane 1 DMA 1 DTPA 1 ATA 1 pentanal 1 Disperse Red 11 1 DFO 1 DEA 1 MMA 1 Genistein 1 ACTH 1 PMA 1 Sitosterol 1 BSO 1 fluoranthene 1 dibromomethane 1 DCB 1 methylphosphonic acid 1 5-HT 1 G11 1 Triton X-100 1 alcohol dehydrogenase 1 6-Methylpurine 1 DAMP 1 acetone 1 Ouabain 1 NTA 1 PEI 1 DES 1 ABPP 1 OMP 1 MIA 1 CIT 1 NaAsO2 1 CPL 1 MAOA 1 Rutin 1 guanidine 1 BCR 1 DBP 1 TEL 1 triethyl phosphate 1 Glycidol 1 2-mercaptoethanol 1 aniline 1

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