Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.4.2.8 (hypoxanthine-guanine phosphoribosyltransferase)
 2,527 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
hypoxanthine-guanine phosphoribosyltransferase 1475
HPRT 1096
Mol 315
AMP 205
Sep 193
X-linked 163
IMP 113
purine nucleoside phosphorylase 76
thymidine kinase 74
GMP 73
HAT 61
ATP 58
adenosine deaminase 57
X-chromosome 57
fused 56
GTP 53
adenosine kinase 51
housekeeping 50
glucose-6-phosphate dehydrogenase 50
G6PD 47
phosphoglycerate kinase 45
PGK 40
p53 40
GAPDH 39
xanthine oxidase 33
5'-nucleotidase 27
X-linked recessive 26
ATPase 26
ACTB 23
hemoglobin 21
SDHA 20
beta-actin 20
NAD 19
lymphoid 18
Gen 17
cytokine 17
glyceraldehyde-3-phosphate dehydrogenase 17
hypoxanthine guanine phosphoribosyltransferase 16
B2M 16
endonuclease 15
cytochrome P450 15
polypeptide 15
amidophosphoribosyltransferase 14
IFN-gamma 14
telomeric 14
promyelocytic leukemia 13
erythroid 13
TBP 13
CYP1A1 12
guanine deaminase 12
glycophorin A 12
T cell receptor 12
YWHAZ 12
AMP deaminase 12
ADP 12
adenylosuccinate synthetase 12
c-myc 12
alpha-galactosidase 11
ras 11
IL-10 11
DNA polymerase 11
PGK1 11
GSTM1 10
HMBS 10
insulin 10
IL-4 10
beta-globin 10
interferon 10
CD4 10
thymus 10
superoxide dismutase 10
oxidoreductase 9
deoxycytidine kinase 9
HLA 9
hMSH2 9
adenylosuccinate lyase 9
p21 9
DNase I 9
Adenosine deaminase 9
IFN 9
PPIA 9
FISH 9
ADA 8
glutathione S-transferase 8
XMP 8
CD8 8
alkaline phosphatase 8
catalase 8
GSTT1 8
dihydrofolate reductase 8
beta-glucuronidase 8
microsomal 8
tRNA 8
AHH 8
interleukin-2 7
cryptic 7
anonymous 7
NAT2 7
GDP 7
nucleoside phosphorylase 7
NADP 7
IMPDH 7
p160 7
hMLH1 7
IL-6 7
adenylate kinase 7
SOD 7
SDS 7
androgen receptor 7
proliferating cell nuclear antigen 7
GSH 7
LDHA 7
Met 6
lectin 6
LPS 6
GLA 6
interleukin 2 6
IL-8 6
threonine 6
STS 6
IL-2 6
PNP 6
cell surface antigen 6
glyceraldehyde 3-phosphate dehydrogenase 6
GPI 6
NMR 6
TGF-beta 6
IL-1 6
ubiquitin 6
UBC 6
CYP1A2 6
phosphorylating 6
GPT 6
MSV 6
surface antigen 6
H2AX 6
Polymerase 6
epidermal growth factor 6
beta-2-microglobulin 5
glycoprotein 5
albumin 5
XPD 5
p22 5
CTP 5
malate dehydrogenase 5
metallothionein 5
TNF 5
RPL13A 5
GMP reductase 5
xanthine dehydrogenase 5
aprt 5
HLA-A 5
deoxyguanosine kinase 5
amyloid precursor protein 5
PGD 5
cytochrome 5
MCL 5
hPMS2 5
DHFR 5
PAH 5
more...
Disease
Lesch-Nyhan syndrome 297
cancer 261
tumor 103
carcinogenesis 91
hyperuricemia 71
gout 56
leukemia 51
mental retardation 40
mental retardation 40
lymphoma 40
carcinoma 29
hepatocellular carcinoma 26
arthritis 25
neuroblastoma 24
choreoathetosis 21
xeroderma pigmentosum 20
enzyme deficiency 19
immunodeficiency 18
self-injurious behavior 17
acute promyelocytic leukemia 17
acute lymphoblastic leukemia 15
renal failure 15
anemia 15
breast cancer 14
HIV 14
lung cancer 14
Schistosoma mansoni 13
tumorigenesis 13
Epstein 12
infectious diseases 12
herpes simplex 12
fibrosarcoma 12
Fanconi 12
nephrolithiasis 11
genetic disorder 11
renal disease 10
acute myeloid leukemia 10
chronic myeloid leukemia 10
CEM 10
neoplastic transformation 10
melanoma 10
embryonal carcinoma 10
vaccinia 9
acute renal failure 8
neurological disease 8
ATM 8
malaria 8
colon cancer 8
Alzheimer's disease 8
tumor progression 8
SDS 7
GSH 7
Infection 7
tuberculosis 7
lung carcinoma 7
STS 7
multiple myeloma 7
blast crisis 7
Mycobacterium 7
MCF 7
ADA deficiency 6
adenocarcinoma 6
depression 6
diabetes 6
Leukemia 6
myelodysplastic syndrome 6
inflammatory bowel disease 6
developmental delay 6
Chagas 6
mantle cell lymphoma 5
Down syndrome 5
cerebral palsy 5
virus infection 5
renal insufficiency 5
colorectal cancer 5
PNP deficiency 5
fragile X syndrome 5
MCL 5
skin cancer 5
BLM 5
urolithiasis 4
SCID 4
Mycoplasma 4
APRT deficiency 4
Turner syndrome 4
Chlamydia 4
tophi 4
chronic lymphocytic leukemia 4
plaque 4
childhood cancer 4
cytomegalovirus 4
AIDS 4
cold 4
mammary tumor 4
renal cell carcinoma 4
chemical carcinogenesis 4
XPD 4
fits 4
Kelley-Seegmiller syndrome 4
PHA 4
suicide 4
paroxysmal nocturnal hemoglobinuria 4
ischemia 3
chronic lymphocytic leukemia 3
Cockayne syndrome 3
Shope fibroma 3
leukemogenesis 3
T-cell lymphoma 3
Duchenne muscular dystrophy 3
West 3
folate deficiency 3
erythroleukemia 3
diphtheria 3
abdominal aortic aneurysm 3
osteosarcoma 3
hemophilia B 3
WRN 3
APC 3
malnutrition 3
AAA 3
epithelial ovarian cancer 3
esophageal cancer 3
schistosomiasis 3
cystic fibrosis 3
CNS diseases 3
ovarian cancer 3
esophageal cancer 3
T-cell acute lymphoblastic leukemia 3
AT3 3
Hodgkin's disease 3
squamous cell carcinoma 3
leishmaniasis 3
cognitive impairment 3
rheumatoid arthritis 3
AT3 3
Gilbert 3
AT3 3
AT3 3
megaloblastic anemia 3
AT3 3
AT3 3
AT3 3
AT3 3
herpes 3
Fanconi syndrome 3
DBA 3
bladder cancer 3
uterus 3
African trypanosomiasis 3
acute leukemia 3
AT3 3
uremia 3
MIP 3
endometrial cancer 2
relapsing fever 2
mouse leukemia L1210 2
SEM 2
systemic lupus erythematosus 2
gouty nephropathy 2
renal impairment 2
more...
Symptom
spasticity 18
dystonia 12
starvation 9
seizures 5
hypotonia 3
vomiting 3
weakness 2
dysarthria 2
clumsiness 2
athetosis 2
chorea 2
pain 2
HSA 2
fatigue 2
diarrhea 1
Ill 1
anorexia 1
nausea 1
colic 1
abdominal pain 1
respiratory distress 1
flank pain 1
renal colic 1
ataxia 1
anesthesia 1
constipation 1
dysuria 1
oliguria 1
tremor 1
chromosome marker 1
hepatomegaly 1
Drug
Mutagen 57
G418 22
lysine 15
IFN-gamma 14
DNase I 9
Adenosine deaminase 9
AZT 8
AZT 8
BH4 8
caffeine 7
IL-2 7
ascorbate 4
Adriamycin 4
IFN-beta 4
Thioguanine 4
Mycophenolic acid 3
MRC 3
TAT 3
THF 3
Gel 3
-deoxyadenosine 3
BLM 3
Dermatol 3
vitamin E 3
Acyclovir 2
Nephron 2
OTC 2
EPI 2
NADH 2
ddI 2
AGG 2
Deoxyadenosine 2
CSF 2
EPA 2
ACT 2
Asn 2
Lead acetate 2
nitroglycerin 2
OTC 2
DMAP 2
Neocarzinostatin 2
ETS 2
8-Azaguanine 2
ampicillin 1
Epivir 1
ETA 1
Azithromycin 1
Etoposide 1
6-Methylpurine 1
Infliximab 1
FLP 1
FAD 1
Proflavin 1
Infliximab 1
Arsenic trioxide 1
Glycerol 1
Hypaque 1
Parkin 1
Hypaque 1
Helium 1
Nitric Oxide 1
KCL 1
PCB 1
Spectrum 1
Cellcept 1
Cellcept 1
CaCl2 1
CaCl2 1
MIL 1
CFX 1
Ouabain 1
PTC 1
Febuxostat 1
CTT 1
Vitamin E 1
Propidium 1
Imatinib 1
Oxaliplatin 1
ABC 1
Meth 1
Gleevec 1
AIC 1
AmBisome 1
ICI 1
Prednisone 1
Formycin B 1
MEA 1
Retinoic acid 1
ROS 1
Glutathione 1
Zmax 1
Nephron 1
Rasburicase 1
CTX 1
OMP 1
AraC 1
TMX 1
Ganciclovir 1
Aztec 1
Areca 1
TEL 1
2-Methoxyethanol 1
Dial 1
Cytidine 1
Spectrum 1
CaCl2 1
NH3 1
Alanine 1
Parkin 1
Enzyme
hypoxanthine-guanine phosphoribosyltransferase 2527
adenine phosphoribosyltransferase 179
phosphoglycerate kinase 81
purine nucleoside phosphorylase 76
thymidine kinase 74
adenosine deaminase 59
adenosine deaminase 57
glucose-6-phosphate dehydrogenase 54
glyceraldehyde-3-phosphate dehydrogenase 51
adenosine kinase 47
5'-nucleotidase 31
xanthine oxidase 31
IMP dehydrogenase 30
ATPase 27
PRPP synthetase 26
xanthine phosphoribosyltransferase 25
glyceraldehyde-3-phosphate dehydrogenase 24
glyceraldehyde-3-phosphate dehydrogenase 18
amidophosphoribosyltransferase 18
glyceraldehyde-3-phosphate dehydrogenase 17
glyceraldehyde-3-phosphate dehydrogenase 17
AMP deaminase 16
endonuclease 15
reverse transcriptase 15
adenylosuccinate synthetase 14
DNA polymerase 13
orotate phosphoribosyltransferase 13
dihydrofolate reductase 13
guanase 12
alpha-galactosidase 12
ERK 12
deaminase 12
superoxide dismutase 12
catalase 11
adenine deaminase 11
RNA polymerase 11
glutathione S-transferase 11
beta-galactosidase 10
adenylosuccinate lyase 10
aldehyde dehydrogenase 9
protein kinase 8
thymidylate synthase 8
alkaline phosphatase 8
trypsin 8
deoxycytidine kinase 8
GMP synthetase 7
adenylate kinase 7
topoisomerase 7
phosphorylase 7
alanine aminotransferase 7
focal adhesion kinase 6
PARP 6
malate dehydrogenase 6
deoxyribonuclease 6
porphobilinogen deaminase 6
S1 nuclease 6
topoisomerase 6
chloramphenicol acetyltransferase 6
peroxidase 6
xanthine dehydrogenase 5
transcriptase 5
orotidine-5'-phosphate decarboxylase 5
deoxyguanosine kinase 5
GMP reductase 5
deoxyadenosine kinase 5
PAH 5
phosphoglucose isomerase 4
DNA ligase 4
PRT 4
cytidine deaminase 4
P-glycoprotein 4
RNase 4
pyruvate kinase 4
AMPK 4
DNA ligase 4
lactate dehydrogenase 4
CYP3A4 4
inosine kinase 4
tyrosinase 4
monoamine oxidase 4
isocitrate dehydrogenase 4
nucleotidase 4
phosphomannose isomerase 3
guanylate kinase 3
nicotinic acid phosphoribosyltransferase 3
glutathione reductase 3
uricase 3
mitogen-activated protein kinase 3
ribokinase 3
galactokinase 3
NQO1 3
complex I 3
RNase 3
AMP-activated protein kinase 3
tyrosine hydroxylase 3
tryptophan hydroxylase 3
beta-glucuronidase 3
luciferase 3
aryl hydrocarbon hydroxylase 3
STR 3
ornithine transcarbamylase 3
6-phosphogluconate dehydrogenase 3
6-phosphogluconate dehydrogenase 3
uracil phosphoribosyltransferase 3
micrococcal nuclease 3
microsomal epoxide hydrolase 3
succinate dehydrogenase 3
methylthioadenosine phosphorylase 3
thiopurine methyltransferase 3
MIP 3
TAT 3
Fpg protein 2
glutathione peroxidase 2
phosphoenolpyruvate carboxylase 2
ribonucleotide reductase 2
S-adenosyl-L-homocysteine hydrolase 2
ribonucleotide reductase 2
DOPA decarboxylase 2
gamma-glutamyl transpeptidase 2
CGT 2
soluble epoxide hydrolase 2
ornithine decarboxylase 2
isocitrate dehydrogenase 2
arylsulfatase 2
UDP-glucuronosyltransferase 2
AMPK 2
DNA methyltransferase 2
HDR 2
proteasome 2
renin 2
collagenase 2
NADPH oxidase 2
TPP 2
inosine triphosphatase 2
ADH3 2
N-acetyltransferase 2
3'-phosphatase 2
tissue plasminogen activator 2
NADPH oxidase 2
phenylalanine hydroxylase 2
DNase 2
glycinamide ribonucleotide transformylase 2
lysozyme 2
AICAR transformylase 2
neuraminidase 2
dihydroorotase 2
adenylate cyclase 2
arginase 2
carbonic anhydrase 2
TPP 2
nucleoside phosphotransferase 2
GMP synthase 2
dihydropyrimidine dehydrogenase 2
phosphodiesterase 2
PDE 2
CTP synthase 2
cathepsin B 2
urease 2
NO synthase 2
uridine phosphorylase 2
more...
Compound
DNA 806
Dec 191
IMP 116
GMP 94
Clin 80
pyrene 61
phosphate 59
pyrimidine 59
pyrimidine 59
AMP 58
ATP 58
GTP 55
sodium 51
oxygen 50
Hypoxanthine 41
EMS 32
arginine 28
Purine 27
water 26
lysine 22
His 20
NAD 20
acetate 19
NAD 19
nitrogen 18
hydrogen 18
glucose 17
uridine 17
retinoic acid 16
methyl methanesulfonate 16
DMSO 16
Guo 15
methionine 15
adenylate 15
calcium 15
DEAE 14
sulfate 14
TBP 13
nitric oxide 13
glutamine 13
Ile 13
valine 13
serine 13
TBP 13
dGTP 13
6-Thioguanine 12
tyrosine 12
Adenine 12
ADP 12
leucine 12
pyridine 12
ADP 12
Adenine 12
ADP 12
aldehyde 11
Asp 11
PRPP 11
Tiazofurin 11
alanine 11
cysteine 11
UTP 10
HPP 10
anthracene 10
creatinine 10
potassium 10
NADP 10
MNNG 10
Inosine 10
Adenosine 10
aspartic acid 9
formaldehyde 9
Phe 9
aspartic acid 9
aspartic acid 9
GAL 9
bromide 9
urea 9
PEG 9
SDS 9
threonine 9
cadmium 9
aspartic acid 9
Mg2+ 8
isoleucine 8
6-Mercaptopurine 8
GDP 8
cAMP 8
ammonium 8
PPi 8
Xanthine 8
chromium 8
isoleucine 8
AZT 8
XMP 8
GSH 7
aflatoxin B1 7
2-hydroxyethyl 7
2-hydroxyethyl 7
formaldehyde 7
2-hydroxyethyl 7
AAF 7
2-hydroxyethyl 7
caffeine 7
2-hydroxyethyl 7
CO2 7
methane 7
GSH 7
2-hydroxyethyl 7
2-hydroxyethyl 7
2-hydroxyethyl 7
acrylamide 7
glucose-6-phosphate 6
Neo 6
BUdR 6
dCTP 6
aldehyde 6
PNP 6
dATP 6
Guanine 6
ethanol 6
manganese 6
GPT 6
silver 6
acetaldehyde 6
tryptophan 6
nickel 5
Styrene 5
CTP 5
iron 5
glutamate 5
3-aminobenzamide 5
1,3-Butadiene 5
methanol 5
DDP 5
BLM 5
NH2 5
acrylonitrile 5
ammonia 5
H2O2 5
glutamic acid 5
PAH 5
zinc 5
Methotrexate 5
proline 5
Gly 5
TNF 5
Guo 4
MTT 4
NOP 4
MIC 4
TPA 4
nicotinic acid 4
PMA 4
TGR 4
MMC 4
CAT 4
benzene 4
AICAR 4
Adriamycin 4
Azan 4
more...