Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.4.2.8 (hypoxanthine-guanine phosphoribosyltransferase)
 2,527 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The mutagenicity for mammalian cells of five n-alkanals produced by lipid peroxidation was tested in V79 Chinese hamster lung cells either at the hypoxanthine-guanine phosphoribosyltransferase locus as resistance to 6-thioguanine or at the Na/K ATPase locus as resistance to ouabain. The results show that propanal, butanal, pentanal and hexanal induced a dose-dependent increase in the frequency over controls of both 6-thioguanine- and ouabain-resistant mutants at concentrations ranging from 3 to 30 mM. With nonanal the same effects were observed with concentrations of 0.1-0.3 mM.
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PMID:Mutagenicity in V79 Chinese hamster cells of n-alkanals produced by lipid peroxidation. 255 Jul 23