Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.4.2.8 (
hypoxanthine-guanine phosphoribosyltransferase
)
2,527
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The genotoxic potential of two occupationally significant chemicals, 4,4'-methylene-bis-2-chloroaniline (
MOCA
) and 2-phenyl-1,4-benzoquinone (PBQ), was explored by monitoring the induction of mutations at the
HPRT
locus of AHH-1 human lymphoblastoid cells. Exposure of AHH-1 cells to the putative carcinogenic metabolite of
MOCA
, N-OH-
MOCA
, induced a 6-fold increase in mutant frequency and resulted in base pair substitutions primarily at A:T base pairs. In contrast, exposure to PBQ did not result in an increased mutant frequency although this compound was significantly more cytotoxic than N-OH-
MOCA
at equimolar doses. The induction of mutations at A:T sites by N-OH-
MOCA
is consistent with the type of DNA damage known to be produced by
MOCA
and provides a specific marker of genotoxic damage for exposed populations.
...
PMID:Mutagenicity of N-OH-MOCA (4-amino-4'-hydroxylamino-bis-3,3'-dichlorodiphenylmethane) and PBQ (2-phenyl-1,4-benzoquinone) in human lymphoblastoid cells. 970 22
