Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.4.2.8 (
hypoxanthine-guanine phosphoribosyltransferase
)
2,527
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The purine hypoxanthine plays important role in regulating oocyte maturation and early embryonic development. The enzyme
hypoxanthine phosphoribosyltransferase
(
HPRT
) recycles hypoxanthine to generate substrates for nucleotide synthesis and key metabolites, and here we show that
HPRT
deficiency in the rat disrupts early embryonic development and causes
infertility
in females.
...
PMID:Hypoxanthine phosphoribosyltransferase (HPRT)-deficiency is associated with impaired fertility in the female rat. 3285 77
