Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.4.2.7 (adenine phosphoribosyltransferase)
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Human Gene/Protein
D16S444E 15.5
tetratricopeptide repeat domain 9C 15.5
vacuolar protein sorting 33A 13.9
aprt 13.5
PPRibP 13.2
transmembrane protein 33 13.2
3',5'-cyclic AMP phosphodiesterase 12.9
POLR2C 12.9
SLC43A3 12.5
phosphoribosyl pyrophosphate amidotransferase 12.5
POLR2F 12.5
adenylate kinase 3 12.5
APT1 12.3
NME5 12.2
5'-methylthioadenosine phosphorylase 12.1
PDHA2 12.0
hypoxanthine guanine phosphoribosyltransferase 11.9
microsomal signal peptidase 11.9
uridine-cytidine kinase 2 11.9
ENTPD3 11.9
NME7 11.8
NME3 11.8
AK5 11.5
APT2 11.5
CHMP1A 11.5
elongation factor 1-beta 11.5
RPB10 11.3
hypoxanthine-guanine phosphoribosyltransferase 11.3
adenosine kinase 11.3
ARAF1 11.2
guanine deaminase 11.2
GMP reductase 11.2
ACSF3 11.2
USP16 11.1
POLR3B 10.9
MTA phosphorylase 10.8
Methylthioadenosine phosphorylase 10.8
UV20 10.8
MDH2 10.6
HPRT 10.6
adenylosuccinate lyase 10.6
amidophosphoribosyltransferase 10.6
EBP2 10.6
AMPD3 10.6
adenosine monophosphate deaminase 10.5
mannose phosphate isomerase 10.5
ADORA3 10.5
STRP 10.5
AT3 10.5
CD39L1 10.4
guanosine monophosphate reductase 10.3
adenylosuccinate synthetase 10.3
purine nucleoside phosphorylase 10.3
FRAP1 10.3
DIA1 10.3
OPRT 10.2
methylthioadenosine phosphorylase 10.1
orphan transporter 10.1
CYL 10.1
ACP2 10.0
MPP1 10.0
PGM3 9.9
VIP36 9.9
DGUOK 9.8
GALNS 9.8
RBM4 9.7
AdoHcyase 9.7
ribokinase 9.7
nucleoside phosphorylase 9.7
MDH1 9.6
AMP 9.6
androgen-regulated protein 9.6
UBE2L3 9.6
MEIS2 9.6
LTK 9.6
CAK 9.5
ADK 9.3
ATF5 9.2
ITM 9.2
glutamine amidotransferase 9.1
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Disease
Deficiency of uracil phosphoribosyltransferase 15.5
APRT*J 15.0
APRT deficiency 15.0
UMP synthase deficiency 13.9
purine metabolism disorder 12.7
gouty nephropathy 11.4
Lesch-Nyhan syndrome 10.7
AT3 10.5
AT3 10.5
AT3 10.5
AT3 10.5
AT3 10.5
AT3 10.5
AT3 10.5
AT3 10.5
AT3 10.5
PNP deficiency 10.2
Serous carcinoma 10.0
colon neoplasm 9.6
orotic aciduria 9.6
urolithiasis 9.2
uricosuria 8.6
ureterolithiasis 8.5
ADA deficiency 8.4
Bradley 7.8
enzyme deficiency 7.7
self-injurious behavior 7.6
papillary serous carcinoma 7.6
HBB 7.6
HBB 7.6
HBB 7.6
XPF 7.4
choreoathetosis 7.3
ornithine transcarbamylase deficiency 7.3
nephrolithiasis 7.1
hyperuricemia 6.9
sideroblastic anemia 6.9
gout 6.7
Morquio 6.7
anuria 6.6
HPP 6.4
embryonal carcinoma 6.4
HPP 6.3
interstitial nephritis 6.2
cystinuria 6.2
TCC 5.8
XPD 5.7
Peutz-Jeghers syndrome 5.6
sarcoma 180 5.5
CEM 5.5
refractory anemia 5.3
mucopolysaccharidosis 5.3
megaloblastic anemia 5.2
glycogen storage disease 5.1
hepatoblastoma 5.1
xeroderma pigmentosum 5.0
TTP 5.0
Rous sarcoma 4.9
B-ALL 4.8
Tay-Sachs disease 4.8
herpes 4.8
giardiasis 4.7
trisomy 4.7
B-cell chronic lymphocytic leukemia 4.7
renal failure 4.5
acute renal failure 4.5
kala-azar 4.5
IVA 4.4
carcinoma of the breast 4.4
TTP 4.4
WRN 4.4
renal insufficiency 4.3
metabolic disorder 4.2
T-cell acute lymphoblastic leukemia 4.2
chronic granulomatous disease 4.1
carcinoma of the breast 4.1
hydronephrosis 4.0
emotional stress 4.0
Fabry 4.0
chronic renal failure 4.0
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Symptom
renal colic 7.4
flank pain 6.4
muscle stiffness 5.2
dysuria 4.2
colic 3.9
spasticity 3.8
starvation 3.5
dystonia 2.5
vomiting 0.5
weakness 0.3
seizures 0.2
diarrhea -0.3
pain -0.9
Drug
6-Methylpurine 13.2
Adenyl 10.8
Mizoribine 8.9
Adenosine deaminase 8.7
Deoxyadenosine 8.5
Cytidine 7.6
Cellulose acetate 7.4
-deoxyadenosine 7.3
ATV 6.9
OMP 6.6
FLP 6.4
TAT 6.3
AGG 5.9
Mutagen 5.8
TTC 5.6
Acyclovir 5.5
DMAP 5.3
BLM 5.1
ACT 4.4
G418 4.4
DNase I 3.5
ICI 3.1
caffeine 3.1
NH3 2.7
THF 2.5
Biopolymers 2.4
CTX 2.2
Nephron 1.9
MAP 1.6
Nephron 1.4
lysine 1.2
NADH 1.1
Dermatol -2.5
Enzyme
adenine phosphoribosyltransferase 15.5
adenosine nucleosidase 13.5
inosine kinase 13.4
xanthine phosphoribosyltransferase 13.1
adenine deaminase 12.9
amidophosphoribosyltransferase 12.0
hypoxanthine-guanine phosphoribosyltransferase 11.7
5'-methylthioadenosine nucleosidase 11.4
PRPP synthetase 11.4
adenosine kinase 11.3
GMP reductase 11.3
nitric-oxide reductase 11.1
uridine hydrolase 11.0
adenylosuccinate lyase 10.9
ribokinase 10.6
nucleoside phosphotransferase 10.6
guanase 10.6
AMP nucleosidase 10.6
purine nucleoside phosphorylase 10.5
methylthioadenosine phosphorylase 10.4
adenylosuccinate synthetase 10.4
3'-phosphatase 10.1
deoxyadenosine kinase 10.1
phosphoglycolate phosphatase 9.9
GMP synthetase 9.8
S-adenosylhomocysteine nucleosidase 9.8
orotate phosphoribosyltransferase 9.7
AMP deaminase 9.6
phosphopentomutase 9.6
CTP synthase 9.6
nucleoside hydrolase 9.4
nicotinic acid phosphoribosyltransferase 9.3
IMP dehydrogenase 9.2
phosphomevalonate kinase 8.9
adenosine deaminase 8.8
PTR1 8.8
uracil phosphoribosyltransferase 8.8
adenosine deaminase 8.8
uridine kinase 8.8
nicotinamidase 8.7
nicotinamide mononucleotide adenylyltransferase 8.5
phosphoserine phosphatase 8.4
deoxyguanosine kinase 8.3
dihydrodipicolinate synthase 8.3
uridine phosphorylase 8.2
xanthine dehydrogenase 8.0
phosphomannose isomerase 8.0
nicotinamide phosphoribosyltransferase 8.0
5'-nucleotidase 7.9
PRT 7.7
branched-chain aminotransferase 7.6
adenylate kinase 7.6
S-adenosyl-L-homocysteine hydrolase 7.4
cytidine deaminase 7.1
orotidine-5'-phosphate decarboxylase 7.1
propionyl-CoA carboxylase 7.1
propionyl-CoA carboxylase 7.1
deoxycytidine kinase 7.0
nitrous oxide reductase 7.0
dihydropyrimidine dehydrogenase 6.8
argininosuccinate lyase 6.8
thymidine kinase 6.7
HMG-CoA synthase 6.6
phosphorylase 6.5
TGT 6.5
nucleotidase 6.5
dihydrofolate reductase 6.4
phosphoglycerate kinase 6.4
TAT 6.3
uricase 6.3
dihydropyrimidine dehydrogenase 6.2
deaminase 6.2
xanthine oxidase 6.0
6-phosphogluconate dehydrogenase 6.0
6-phosphogluconate dehydrogenase 6.0
AGT 5.9
sucrose synthase 5.9
N-acetyltransferase 5.9
alpha-galactosidase 5.8
arginine deiminase 5.7
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Compound
6-Ethylmercaptopurine 15.5
8-Azainosine 14.5
dimethyloctanoate 13.9
C7H8N4S 13.5
6-Methylpurine 13.2
2-Azahypoxanthine 13.2
6-Methylpurine 12.9
C5H5NO 11.9
Xanthosine 11.7
3-hydroxy-2-pyrazinecarboxamide 11.6
5-methyl-cytidine 11.5
N-methyladenine 11.4
PRPP 11.2
Coformycin 11.1
2,6-DMA 10.5
Hypoxanthine 9.9
Adenine 9.4
3-methoxybenzamide 9.2
XMP 9.2
XTP 9.2
1-methylhistidine 9.0
IMP 8.9
Tiazofurin 8.8
Inosine 8.7
Deoxycytidine 8.7
Acivicin 8.7
Purine 8.6
Deoxyadenosine 8.6
Adenine 8.6
MTA 8.4
triethyl phosphate 8.3
4-NQO 8.3
Lupeol 8.2
Xanthine 8.0
C56 8.0
dCTP 7.9
APT 7.8
AIR 7.8
Deoxycoformycin 7.7
MNNG 7.6
HBB 7.6
HPP 7.3
DHA 7.3
DHA 7.2
Cyd 7.1
HBA 7.1
Ribose 7.0
Thymine 7.0
DAP 7.0
DAP 6.9
GMP 6.9
PhIP 6.9
6-Mercaptopurine 6.8
SAH 6.8
EMS 6.8
ribose-5-phosphate 6.8
adenylate 6.8
TGT 6.8
DHA 6.7
Pyrazinamide 6.6
BUdR 6.5
OMP 6.5
pyrimidine 6.5
pyrimidine 6.5
dGMP 6.4
TTP 6.4
AMP 6.4
Malate 6.4
Adenosine 6.2
Parks 6.1
PPi 6.1
Guo 6.1
S-adenosylhomocysteine 6.1
dGTP 6.1
dATP 6.0
Uric acid 6.0
Guanine 6.0
DMAP 6.0
DMAP 6.0
Benzo[a]pyrene 6.0
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