Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.4.2.7 (
adenine phosphoribosyltransferase
)
692
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Interspecific somatic cell hybrids were generated by fusion of Chinese hamster spleen cells or primary fibroblasts with cells from an
adenine phosphoribosyltransferase
(
APRT
)-deficient mouse subline derived from LMTK- Cl.1D. Subclones which had been selected for either retention or loss of
APRT
were subjected to combined isozyme and chromosome segregation analysis. Concordant expression or segregation of Chinese hamster
APRT
,
lactate dehydrogenase A
(
LDHA
), isocitrate dehydrogenase 2 (IDH2), and alpha-glucosidase (GAA) with Chinese hamster chromosome 3 allowed provisional assignment of all four loci to that chromosome. Exceptional subclones, in which coordinate segregation of these syntenic markers was disrupted by chromosome breakage or deletions, allowed further localization of these genes to specific regions of the 3 chromosome.
...
PMID:Gene mapping and linkage analysis in Chinese hamster: assignment of the genes for APRT, LDHA, IDH2, and GAA to chromosome 3. 635 27
