Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.4.2.7 (adenine phosphoribosyltransferase)
 692 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty-three silver fox-Chinese hamster somatic cell hybrids were analysed for the expression of fox enzyme loci and the segregation of fox chromosomes. This analysis made it possible to assign the gene PGD to chromosome 2, MDH2 to chromosome 3. NP to chromosome 10. APRT, ENO1, PGM1 to chromosome 12, MDH1 and IDH1 to chromosome 16. Possible use of the above-mentioned clone panel for fox gene mapping is analysed. An attempt to reveal homologous regions on fox and human chromosomes was made by comparative analysis of prometaphase fox and human chromosomes containing the homologous genes. The means and perspectives of verification of the hypothesis proposed are discussed.
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PMID:[Genome mapping of the silver fox. I. Determination of the chromosomal location of 8 fox genes and the search for homologous regions on fox and human chromosomes]. 316 22

Twenty-three silver fox x hamster somatic cell hybrid clones were used to assign 15 fox genes: GPI to chromosome 1; PGD to chromosome 2; MDH2 to chromosome 3; ESD to chromosome 6; LDHB to chromosome 8; NP to chromosome 10; LDHA to chromosome 11; APRT, ENO1, and PGM1 to chromosome 12; IDH1 and MDH1 to chromosome 16; and GLA, G6PD, and HPRT to the X chromosome. High-resolution G-banding of human, cat, mink, and fox chromosomes containing homologous regions (according to genetic maps) revealed regions of putative homology. The results lend support to the suggestion that the most considerable karyotypic reorganization of the ancestral genome in the order Carnivora occurred during Canidae formation. The details of karyotypic evolution in mammals are discussed.
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PMID:Silver fox gene mapping: conserved chromosome regions in the order Carnivora. 319 55

The use of common names which may encompass a number of subspecies or species is pervasive in the biomedical literature. Failure to identify the complete taxonomic classification of research subjects presents a source of error for scientists attempting to evaluate results or to repeat experiments. This paper examines the problem in a common animal model, the baboon. Analyses of the genetic distances among five baboon subspecies (Papio hamadryas anubis, P.h. cynocephalus, P.h. papio, P.h. ursinus, and P.h. hamadryas) based on blood marker information from nine polymorphic protein loci (ADA, APRT, C3, CA1, CA2, GPI, MPI, PEPB, and PGD) available for baboons resident at the Southwest Foundation for Biomedical Research are presented. Statistical tests on the distances showed that significant genetic differences exist among the subspecies. A comparison of P.h. anubis and P.h. cynocephalus revealed that these two subspecies also differ significantly for biomedically relevant lipoprotein cholesterol levels, as can be predicted from the genetic distances. The results emphasize the pitfalls of using different types of baboons interchangeably in experimental protocols.
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PMID:Genetic differentiation between baboon subspecies: Relevance for biomedical research. 3196 94