Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.4.2.7 (adenine phosphoribosyltransferase)
 692 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Analysis of CHO electrophoretic mobility shift mutants for six enzyme loci ( LDHA , GAA, IDH2 , ME1, PGM3, and MPI) that have been previously mapped to Chinese hamsters chromosomes 3 and 4 indicated that each of these loci, with the exception of IDH2 , are functionally dizygous in CHO. Segregation analysis of CHO X mouse somatic cell hybrids allowed regional gene mapping assignments for a total of eight Chinese hamster chromosome 3- or 4-derived marker loci (the above six, plus APRT and PKM2) to CHO chromosomes Z3 , Z4 , Z5 , and Z7 . For seven of these enzyme loci (all but IDH2 ), two alleles are expressed in CHO cells, each segregating with a different Z-group chromosome. These gene mapping assignments confirm genetically that CHO chromosomes Z3 , Z4 , Z5 , and Z7 are, in fact, derived from Chinese hamster chromosomes 3 and 4, and provide insight into the effects of chromosomal rearrangements on gene expression and hemizygosity in CHO cells.
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PMID:Chromosomal rearrangements and gene expression in CHO cells: mapping of alleles for eight enzyme loci on CHO chromosomes Z3, Z4, Z5, and Z7. 658 72

The use of common names which may encompass a number of subspecies or species is pervasive in the biomedical literature. Failure to identify the complete taxonomic classification of research subjects presents a source of error for scientists attempting to evaluate results or to repeat experiments. This paper examines the problem in a common animal model, the baboon. Analyses of the genetic distances among five baboon subspecies (Papio hamadryas anubis, P.h. cynocephalus, P.h. papio, P.h. ursinus, and P.h. hamadryas) based on blood marker information from nine polymorphic protein loci (ADA, APRT, C3, CA1, CA2, GPI, MPI, PEPB, and PGD) available for baboons resident at the Southwest Foundation for Biomedical Research are presented. Statistical tests on the distances showed that significant genetic differences exist among the subspecies. A comparison of P.h. anubis and P.h. cynocephalus revealed that these two subspecies also differ significantly for biomedically relevant lipoprotein cholesterol levels, as can be predicted from the genetic distances. The results emphasize the pitfalls of using different types of baboons interchangeably in experimental protocols.
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PMID:Genetic differentiation between baboon subspecies: Relevance for biomedical research. 3196 94