Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:2.4.2.30 (PARP)
13,611 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein PARP 10709 caspase-3 4192 PARP-1 2521 poly(ADP-ribose) polymerase 2366 Bcl-2 2091 ADP 1685 p53 1385 Mol 1340 caspase-9 1182 poly (ADP-ribose) polymerase 1142 cytochrome c 1087 ADP-ribosyltransferase 1021 Sep 851 NAD 847 caspase-8 790 BRCA1 697 Poly 696 p21 619 Poly(ADP-ribose) polymerase 579 annexin V 547 p38 517 ATP 487 PARP1 467 AKT 455 JNK 443 PI3K 421 ROS 412 mTOR 394 BRCA2 379 ERK 363 MAPK 363 Fas 330 PAR 313 cyclin D1 312 NAD+ 301 ERK1 282 histone 269 TNF 268 Bid 265 survivin 258 H2AX 255 Mcl-1 255 endoplasmic reticulum 248 LC3 244 ATM 238 cytochrome 234 PARP-2 231 tumor necrosis factor 205 apoptosis-inducing factor 196 p27 191 GSH 190 cytokine 186 DNA-dependent protein kinase 167 c-Jun 166 Pseudomonas 164 Bak 163 inducible nitric oxide synthase 162 XIAP 159 p65 156 RAD51 150 STAT3 149 anti-apoptotic protein 147 catalase 146 cyclin B1 144 HER2 144 bcl-2 143 PARG 143 proliferating cell nuclear antigen 143 BAX 135 proteasome 135 MMP-9 132 GTP 132 ATR 131 superoxide dismutase 131 CHOP 130 IL-6 127 PC-3 126 CDK4 125 EGFR 124 MEK 122 extracellular signal-regulated kinase 122 insulin 121 lactate dehydrogenase 120 catenin 118 cyclin E 117 histone deacetylase 116 epidermal growth factor receptor 116 VEGF 115 p62 114 TRAIL 113 tyrosine kinase 113 AIF 110 PTEN 110 CPP32 110 COX-2 108 osteosarcoma 107 estrogen receptor 106 bax 104 pro-apoptotic protein 104 cyclin 102 poly(ADP-ribose) glycohydrolase 101 lipopolysaccharide 99 NMR 95 nuclear protein 93 DR5 91 ubiquitin 91 cyclin A 91 NAC 90 FasL 90 Bax protein 89 c-Myc 88 XRCC1 88 Chk1 86 LDH 85 vascular endothelial growth factor 85 CDK2 85 DNA repair enzyme 85 Beclin-1 83 53BP1 83 collagen 83 proteasome inhibitor 82 Bcl-X 82 AMPK 79 GRP78 79 SIRT1 78 Rho 78 calpain 76 mitogen-activated protein 75 androgen receptor 72 Fas ligand 71 Smac 70 polypeptide 70 MMP-2 69 inhibitor of apoptosis 69 E-cadherin 69 cyclooxygenase-2 69 colon carcinoma 68 topoisomerase I 68 Nrf2 68 CD95 66 Cyclin D1 66 SOD 65 WAF1 64 TNF-alpha 64 CCK 63 kit 63 nitric oxide synthase 63 PERK 62 myeloperoxidase 62 JNK1 62 endonuclease 62 Poly(ADP-ribose)polymerase 62 Chk2 61 AP-1 61 GSK 61 ICAD 60 BCL2 60 mutant p53 59 histone H3 59 phosphatidylinositol 3-kinase 59 more...

Disease cancer 4520 tumor 2358 breast cancer 1122 tumor growth 577 ovarian cancer 551 leukemia 503 carcinoma 425 MCF 423 prostate cancer 398 hepatocellular carcinoma 353 lung cancer 347 ischemia 323 colon cancer 313 ATM 277 diabetes 259 melanoma 247 carcinogenesis 244 colorectal cancer 239 tumorigenesis 234 adenocarcinoma 218 pancreatic cancer 191 GSH 190 neuroblastoma 178 non-small cell lung cancer 175 glioma 165 gastric cancer 165 tumor progression 154 cholera 153 lymphoma 151 squamous cell carcinoma 147 stroke 141 glioblastoma 140 cervical cancer 138 epithelial ovarian cancer 135 multiple myeloma 133 acute myeloid leukemia 127 B-cell lymphoma 121 osteosarcoma 118 pertussis 117 diphtheria 109 Parkinson's disease 108 Alzheimer's disease 105 cerebral ischemia 104 liver cancer 102 metastases 93 chronic myeloid leukemia 89 DDP 81 lung carcinoma 79 liver cancer 78 acute promyelocytic leukemia 70 hyperglycemia 68 metastatic breast cancer 65 skin cancer 63 MTS 59 chronic lymphocytic leukemia 58 bladder cancer 58 anemia 57 retinoblastoma 57 AGS 57 atherosclerosis 54 oral cancer 51 renal cell carcinoma 50 myocardial infarction 49 myocardial ischemia 48 acute lymphoblastic leukemia 48 chronic lymphocytic leukemia 47 Hepatocellular carcinoma 46 heart failure 45 colitis 43 Leukemia 43 SDS 43 sepsis 43 Ewing's sarcoma 42 Bordetella 42 HIV 42 obesity 41 sepsis 41 glioblastoma multiforme 41 SCID 39 Blocking 38 asthma 38 recurrent ovarian cancer 37 virus infection 36 brain tumor 35 hypertension 35 myeloid leukemia 35 infectious diseases 34 FAS 34 esophageal cancer 33 Melanoma 33 rheumatoid arthritis 33 cold 32 Epstein 32 renal cancer 32 arthritis 31 Burkitt's lymphoma 31 Osteosarcoma 30 Osteosarcoma 30 endometrial cancer 30 Fanconi 30 solid tumor 30 small cell lung cancer 29 sarcoma 28 head and neck cancer 27 esophageal cancer 26 Infection 26 type 2 diabetes 26 cognitive impairment 26 liver fibrosis 24 osteoarthritis 24 APC 24 cardiomyopathy 23 Pineal 23 WRN 23 mantle cell lymphoma 23 CEM 22 neuropathy 22 pheochromocytoma 22 immunodeficiency 21 multiple sclerosis 21 diabetic nephropathy 21 aggressiveness 21 renal disease 21 ABL 20 tumor angiogenesis 20 amyotrophic lateral sclerosis 20 NAME 20 primary tumor 20 mesothelioma 20 SAR 20 dementia 19 Glioblastoma 19 Hodgkin's disease 19 Nasopharyngeal carcinoma 19 TEM 19 NOD 19 depression 18 encephalomyelitis 18 cardiovascular disease 18 malnutrition 18 BLM 18 chronic obstructive pulmonary disease 18 fallopian tube 18 systemic lupus erythematosus 18 diabetic neuropathy 17 influenza 17 anthrax 17 thrombocytopenia 17 type 1 diabetes 17 fibrosarcoma 16 acute leukemia 16 hepatitis 16 medulloblastoma 16 T-cell lymphoma 16 insulinoma 16 AIDS 16 neutropenia 16 memory impairment 16 suicide 16 herpes simplex 16 more...

Symptom collapse 94 starvation 37 pain 36 diarrhea 31 fatigue 21 nausea 21 seizures 16 hypothermia 15 respiratory distress 15 functional recovery 15 hyperoxia 14 exhaustion 12 vomiting 11 weakness 10 ataxia 9 anesthesia 8 cachexia 7 headache 7 skin damage 7 Neuropathic pain 6 acute stress 5 asthenia 4 thinning 4 acidity 4 erythema 4 abdominal pain 4 menopausal symptoms 3 stigma 3 decreased appetite 3 splenomegaly 3 nausea and vomiting 3 cough 3 dyspnea 3 insomnia 2 discomfort 2 hepatomegaly 2 numbness 2 constipation 2 memory loss 2 analgesia 2 discomfort 2 stomach pain 2 pelvic pain 1 Floppy 1 Ill 1 despair 1 arthralgia 1 bradykinesia 1 neurological disability 1 tingling 1 chills 1 colic 1 HSA 1 agitation 1 hot flashes 1 tremor 1 impaired motor coordination 1 back pain 1 Welt 1 anorexia 1 eds 1 male subfertility 1 bone pain 1 Induced hypothermia 1 dry eye 1 vertigo 1 ENT 1 limb pain 1 angina 1 hypercapnia 1 overweight 1

Drug ROS 412 lysine 88 NADH 57 ascorbate 41 MAP 33 vitamin E 31 caffeine 31 IL-2 28 Arsenic trioxide 26 Monit 26 Dermatol 25 niacin 22 AMC 22 Taxol 20 Cardiovasc 20 Glycyrrhiza 19 Bortezomib 19 ETS 17 NVP 17 CED 17 IFN-gamma 17 Etoposide 16 Mutagen 16 DNase I 15 MRC 15 CPT-11 14 ADR 14 Imatinib 14 BLM 13 Sorafenib 13 CSF 13 TTC 12 Ethanol 12 Gel 12 CTX 12 p75 12 Indomethacin 12 Glutathione 12 Bevacizumab 11 Emodin 10 Emodin 10 Docetaxel 10 Adriamycin 9 Asn 9 Gefitinib 9 Herceptin 9 Heme 9 Parkin 8 DM1 8 Parkin 8 Leaf 8 ABC 7 ampicillin 6 3-Methyladenine 6 CTX 6 Simvastatin 6 -deoxyadenosine 6 Irinotecan 6 CTX 6 Flavopiridol 6 PFT 6 Nitric Oxide 6 Lovastatin 5 Oxaliplatin 5 CAM 5 EE2 5 Vitamin E 5 ETA 5 MDM 5 DHT 5 Dihydro 5 Gelatin 5 CCL 5 DHT 5 Lenalidomide 5 Rituximab 5 Rosiglitazone 5 2-Methoxyestradiol 5 RFP 5 Nephron 5 ADM 5 Asthma 5 Amiloride 4 Histamine 4 NBT 4 uPA 4 Fluorescein 4 Epigallocatechin 4 Erlotinib 4 VCR 4 Vitamin K 4 Everolimus 4 lactose 4 CTA 4 Portal 4 CoCl2 4 CoCl2 4 Retinoic acid 4 Photofrin 4 VCR 4 Angiotensin II 4 IFN-beta 4 Fraction 4 Gleevec 4 Cetuximab 4 ICI 4 Silica 3 PBZ 3 Purvalanol 3 Radicicol 3 Fragment 3 APD 3 Romidepsin 3 3-Methoxybenzamide 3 Cantor 3 GEO 3 Taxotere 3 MDS 3 citric acid 3 Tannic acid 3 Pertuzumab 3 Troglitazone 3 NAG 3 Vorinostat 3 Ouabain 3 ZnO 3 Glutamic acid 3 Verteporfin 3 Zoledronic acid 3 Albumin 3 Alanine 3 Phosphatidylserine 3 Tolfenamic acid 3 SNL 3 ENT 3 nitroglycerin 3 Xanthium 3 Tranilast 2 Riboflavin 2 Aloe 2 Kainic acid 2 Ringer's solution 2 FAD 2 Acacia 2 TRM 2 Fluorescein 2 Vandetanib 2 Fidarestat 2 IL-1ra 2 Orphan 2 Rimonabant 2 Podophyllotoxin 2 AZT 2 CTC 2 Myricetin 2 Zoledronic acid 2 TAC 2 Pemetrexed 2 Panitumumab 2 Swainsonine 2 more...

Enzyme PARP 13611 caspase-3 3345 mitogen-activated protein kinase 1114 ADP-ribosyltransferase 1024 ADP-ribosyltransferase 1021 caspase-9 966 ERK 697 caspase-8 625 protein kinase 314 superoxide dismutase 188 cdc2 179 focal adhesion kinase 177 caspase-7 176 caspase-7 172 MEK 162 catalase 160 proteasome 135 topoisomerase 123 lactate dehydrogenase 123 protein kinase C 122 topoisomerase 120 caspase-1 116 AMP-activated protein kinase 115 luciferase 115 poly(ADP-ribose) glycohydrolase 101 DNA ligase 99 DNA ligase 99 AMPK 86 AMPK 79 peroxidase 76 DNA polymerase 69 endonuclease 62 GSK 62 phosphatidylinositol 3-kinase 59 MMP 56 ATPase 53 glutathione S-transferase 53 NADPH oxidase 51 P-glycoprotein 51 glutathione peroxidase 49 alanine aminotransferase 48 caspase-2 47 NAD glycohydrolase 46 NADPH oxidase 46 caspase-2 45 phospholipase C 43 ACS 42 RNA polymerase 42 IKK 41 caspase-6 41 NO synthase 41 NQO1 41 phosphoinositide 3-kinase 40 phosphodiesterase 38 trypsin 37 caspase-6 36 aspartate aminotransferase 35 adenylate cyclase 34 MAP 31 calcineurin 31 complex I 25 APC 23 creatine kinase 22 DNase 22 reverse transcriptase 22 NOS 21 glyceraldehyde-3-phosphate dehydrogenase 21 MPP 21 DNA methyltransferase 20 cathepsin B 20 nitrogenase 20 AST 17 phospholipase A2 17 glyceraldehyde-3-phosphate dehydrogenase 16 venom phosphodiesterase 16 prostate-specific antigen 16 xanthine oxidase 16 acetylcholinesterase 16 alkaline phosphatase 16 glyceraldehyde-3-phosphate dehydrogenase 15 RNase 15 glutathione reductase 15 caspase-4 15 glyceraldehyde-3-phosphate dehydrogenase 15 glyceraldehyde-3-phosphate dehydrogenase 15 PDK1 14 heme oxygenase 14 thioredoxin reductase 14 caspase-4 14 polo-like kinase 1 13 nicotinamide phosphoribosyltransferase 13 MIP 13 ricin 13 MDR 13 beta-galactosidase 13 phospholipase D 13 cathepsin D 12 peroxiredoxin 12 histone acetyltransferase 12 Omi/HtrA2 11 RNase 11 granzyme B 11 DCF 11 glucose oxidase 11 TdT 11 protein phosphatase 2A 11 tyrosine hydroxylase 11 aldose reductase 10 thrombin 10 chymotrypsin 10 chloramphenicol acetyltransferase 10 thymidine kinase 10 urokinase-type plasminogen activator 10 dinitrogenase reductase-activating glycohydrolase 10 caspase-10 10 mu-calpain 9 succinate dehydrogenase 9 acetyl-CoA carboxylase 9 caspase-10 9 CEP 8 collagenase 8 ribonucleotide reductase 8 ribonucleotide reductase 8 demethylase 8 CEP 8 ADP-ribosylarginine hydrolase 8 glutamine synthetase 8 ornithine decarboxylase 7 histone demethylase 7 m-calpain 7 CAD 7 PKG 7 CAD 7 TSA 7 ACE 7 guanylate cyclase 7 MTD 7 aldehyde dehydrogenase 7 cytochrome oxidase 7 tissue plasminogen activator 7 CAD 7 MEKK1 7 gamma-glutamylcysteine synthetase 7 isocitrate dehydrogenase 6 isocitrate dehydrogenase 6 DNase II 6 hypoxanthine-guanine phosphoribosyltransferase 6 deoxyribonuclease 6 prostate-specific membrane antigen 6 aldehyde dehydrogenase 6 aldehyde dehydrogenase 6 transglutaminase 6 lipase 6 transcriptase 6 aldehyde dehydrogenase 6 renin 6 aldehyde dehydrogenase 6 sphingosine kinase 6 lipoxygenase 5 deoxyribonuclease 5 more...

Compound DNA 5221 ADP-ribose 1867 ADP 1816 ADP 1690 ADP 1686 oxygen 1408 NAD 1135 Dec 913 NAD 847 MTT 635 ATP 487 nicotinamide 436 MDA 384 cysteine 321 PAR 313 3-aminobenzamide 289 Clin 283 TNF 268 glucose 267 calcium 257 hydrogen 240 nitric oxide 233 arginine 228 N-acetylcysteine 224 iodine 221 water 202 GSH 198 GSH 198 bromide 177 Asp 158 sodium 153 dUTP 147 serine 147 alanine 137 tyrosine 135 GTP 133 zinc 132 H2O2 126 nitrogen 122 MEK 117 phosphate 113 lysine 109 glutamate 106 DDP 104 ethanol 99 Panam 90 acetate 90 Curcumin 90 threonine 83 AMP 68 NH2 65 benzamide 65 acridine 65 urea 63 ADR 62 iron 60 MTS 59 Hoechst 33342 59 boron 58 NADH 57 Adriamycin 56 methionine 53 retinoic acid 52 Ribose 52 salt 51 cAMP 51 creatinine 50 galactose 49 methanol 49 THP 49 THP 49 ethyl acetate 48 Resveratrol 47 sulfate 47 Cytochrome c 45 Cyt 44 His 44 cadmium 44 SDS 43 ACS 42 ACS 42 selenium 41 leucine 40 GDP 40 Quercetin 39 chalcone 38 pyridine 37 pyrimidine 36 copper 36 pyrimidine 35 methyl methanesulfonate 34 diacetate 34 glutamic acid 34 ammonium 33 adenylate 33 5-FU 32 CAT 32 VP-16 32 caffeine 31 MAP 31 NMDA 31 Phe 30 aldehyde 30 aldehyde 30 glutamine 30 Mg2+ 29 MIA 29 aspartic acid 28 Cereb 28 8-OHdG 28 hydroxylamine 28 aspartic acid 28 DMSO 28 aspartic acid 27 aspartic acid 27 hydroxylamine 27 fluorine 27 tryptophan 26 Neuronal 26 NO3 25 PEG 25 BCR 25 Metformin 24 isoquinoline 24 NADP 24 hexane 24 Metformin 24 pyrrolidine 23 Melatonin 23 PGE 23 pyrene 23 MPTP 23 potassium 23 Cardiol 23 Vimentin 22 cGMP 22 benzene 22 silver 22 STZ 22 NOXA 21 Pac 21 Gly 21 MPP 21 MPP 21 quinoline 21 NADPH 21 NADPH 21 Histone 21 quinoline 21 SCC 20 naphthoquinone 20 TEM 20 naphthoquinone 20 GSSG 20 ABL 20 naphthoquinone 20 COX 20 naphthoquinone 20 naphthoquinone 20 ATF 20 more...

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