Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.4.2.30 (
PARP
)
13,611
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
There is extensive literature on PARP1, owing to the multiple functions of PARP1 for DNA repair, aging, chromatin remodeling and transcription, and to the successful clinical development of four
PARP
inhibitors. In this issue of
Cancer Research
, Wang and colleagues identified phosphatase 1 nuclear targeting subunit (PNUTS, also referred to as
PP1R10
) as a partner of PARP1 and demonstrated that PNUTS and PARP1 are interdependent for their recruitment to DNA damage sites. As PARP1 is a prominent target for cancer therapy and PNUTS has
PARP
-dependent as well as PARP1-independent activities, the findings of Wang and colleagues add insight into DNA repair mechanisms with potential application to drug targeting and precision therapy.
See related article by Wang et al., p. 2526
.
...
PMID:Phosphatase 1 Nuclear Targeting Subunit, a Novel DNA Repair Partner of PARP1. 3073 93
