Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.4.2.30 (
PARP
)
13,611
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Apoptosis signal-regulating kinase 2
(
ASK2
) is an interaction partner of the highly related ASK1. Here, we describe a regulatory function of
ASK2
in stress signaling-induced cleavage of caspase-3 and poly(ADP-ribose) polymerase (
PARP
). Increased cleavage of caspase-3 and
PARP
was demonstrated by overexpression as well as knockdown of
ASK2
after stress-induction by serum-starvation. We show that ectopically expressed
ASK2
homo-oligomerized while endogenous
ASK2
and ASK1 formed hetero-oligomers, which decreased upon serum-starvation. Co-expression of
ASK2
and ASK1 stabilized these two proteins and reduced starvation-induced caspase-3 activation and degradation of
PARP
. Analysis of the intracellular localization of
ASK2
exhibited a similar localization compared with ASK1 in the nucleus, cytoplasm, and in mitochondria. We propose that
ASK2
regulates stress-induced caspase-3 and
PARP
cleavage in a dose-dependent manner by heteromeric complex formation with ASK1.
...
PMID:Heteromeric complex formation of ASK2 and ASK1 regulates stress-induced signaling. 1771 88
