Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.4.2.30 (
PARP
)
13,611
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Human
CMTM3
has been proposed as a putative tumor suppressor gene. The loss of
CMTM3
has been found in several carcinomas. However, the regulation of
CMTM3
expression and its function in tumor progression remain largely unknown. Here, we investigated the regulation of
CMTM3
expression, function and molecular mechanism in human testicular cancer cells.
CMTM3
was frequently downregulated or silenced in testicular cancer cell lines and tumor tissues but highly expressed in normal testis tissues. The re-expression of
CMTM3
significantly suppressed the colony formation, proliferation, and migration capacity of testicular cancer cells by inducing a G2 cell cycle arrest and apoptosis. Moreover, the re-expression of
CMTM3
activated the transcription of p53, induced p53 accumulation, up-regulated the expression of p21, and increased the cleavage of caspase 9, 8, 3, and
PARP
. The downregulation of
CMTM3
in clinical tumor tissues was associated with the methylation of a single CpG site located within the Sp1/Sp3-responsive region of the core promoter. These results indicate that
CMTM3
can function as tumor suppressor through the induction of a G2 cell cycle arrest and apoptosis.
CMTM3
is thus involved in testicular cancer pathogenesis, and it is frequently at least partially silenced by the methylation of a single, specific CpG site in tumor tissues.
...
PMID:CMTM3 inhibits human testicular cancer cell growth through inducing cell-cycle arrest and apoptosis. 2629 62
