Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.4.2.30 (
PARP
)
13,611
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A new, efficient, and versatile one-pot cascade reaction of diverse Gewald's aminothiophenes, 2-hydroxy-4-oxobut-2-enoic acid, and derivatives of
cyanoacetic acid
catalyzed by Et
3
N is presented. It enables direct synthesis of diverse 1-(2-oxoethylidene)-2-oxothieno[3,2-
e
]pyrrolo[1,2-
a
]pyrimidine in good to excellent yields. The reaction exhibits a broad substrate scope and also presents an opportunity for further modification of the structure. The method offers a convenient practical alternative to the known procedures. The synthesized thieno[3,2-
e
]pyrrolo[1,2-
a
]pyrimidine scaffold is an important structural motif of new poly(ADP-ribose) polymerase (
PARP
) inhibitors, playing a useful role in multiple pharmacological applications.
...
PMID:One-Pot Synthesis of Thieno[3,2-
e
]pyrrolo[1,2-
a
]pyrimidine Derivative Scaffold: A Valuable Source of PARP-1 Inhibitors. 3176 74
