Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.4.2.30 (
PARP
)
13,611
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Treatment of rat basophilic leukemia cell line (2H3) with interferon-alpha significantly increased intracellular histamine levels. On the other hand, the histidine content was decreased reciprocally by interferon in a dose-dependent manner. Concomitantly, the activity of
histidine decarboxylase
, the enzyme responsible for histamine synthesis, was augmented. The increase in
histidine decarboxylase
activity was partially abolished in co-incubation with inhibitors of
ADP-ribosyltransferase
, such as 3-aminobenzamide or nicotinamide. These results suggest the pivotal role of activation of
histidine decarboxylase
, presumably through ADP-ribosylation of the enzyme, in interferon-induced histamine synthesis.
...
PMID:Induction of histidine decarboxylase in rat basophilic leukemia cells by interferon and prevention of its effect in coincubation with ADP-ribosyltransferase inhibitors. 252 50
