Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.4.2.30 (
PARP
)
13,611
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Batillus cornutus (B. cornutus) is one of the gastropoda, which are distributed along the coast of China, Japan and South Korea and northeast area. In this study, we first identified the antioxidant effects of a B. cornutus meat (BM) enzymatic hydrolysate in H
2
O
2
-treated Vero cells. First of all, we prepared an Alcalase hydrolysate from BM (
BMA
) and revealed a high taurine content. Also, taurine rich
BMA
dose-dependently increased 2,2-azino-bis(3-ethylbenzthiazoline)-6-sulfonic acid (ABTS) radical scavenging activity, reducing power and the higher oxygen radical absorbance capacity (ORAC) value. In addition,
BMA
significantly increased the cell viability via the down-regulation of intracellular reactive oxygen species (ROS) production, as well as the decreased formation of apoptotic bodies and sub-G
1
DNA population in H
2
O
2
-treated Vero cells. Furthermore,
BMA
increased the expression of the anti-apoptotic molecule, Bcl-2, and decreased the expressions of Bax, p53 and cleaved
PARP
, all of which are pro-apoptotic molecules, in H
2
O
2
-treated Vero cells. Based on these results, this study suggests that
BMA
may be used as a potential protector on damage caused by oxidative stress.
...
PMID:Antioxidant Effects of an Alcalase Hydrolysate from Batillus cornutus Meat. 3146 37
