Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.4.2.30 (
PARP
)
13,611
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The enzyme poly(ADP-ribose) polymerase (
PARP-1
,
EC 2.4.2.30
) is activated by DNA strand breaks caused by several agents and utilizes NAD to form polyADPR, bound to acceptor proteins. The involvement of
PARP-1
in autoimmune diseases has been suggested: antiPARP autoantibodies are described in systemic lupus erythematosus (SLE), DNA strand breaks have been evidenced in systemic sclerosis (SSc). We tested poly(ADP-ribosyl)ation activity and NAD concentration in
PMC
from patients affected by SLE or SSc and from controls. Lower
PARP-1
activity and higher NAD concentration were observed in pathological conditions than controls, supporting the role of
PARP-1
activation in modulating NAD concentration.
...
PMID:PARP activity and NAD concentration in PMC from patients affected by systemic sclerosis and lupus erythematosus. 2054 40
