Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.4.2.30 (
PARP
)
13,611
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Chromatographic purification of a methanol extract of the roots of
Lespedeza bicolor
led to the isolation of four new pterocarpans (
1
-
4
), two new coumestans (
6
and
7
), two new arylbenzofurans (
8
and
9
), and the known pterocarpan 1-methoxyerythrabyssin II (
5
). Their structures were identified using NMR spectroscopy, UV spectroscopy, and mass spectrometry. Cytotoxicity assays showed that compounds
1
-
9
exerted antiproliferative effects on
blood cancer
cells. Of these compounds,
1
and
6
induced mitochondrial depolarization and induced apoptosis in Jurkat cells. These compounds promoted cell death by inducing cell-cycle arrest at the G1 stage, reducing levels of BCL2, and increasing cleavage of
PARP-1
. These findings indicate that
1
and
6
are possible lead compounds for the treatment of human leukemia cells via intracellular signaling.
...
PMID:Antiproliferative Pterocarpans and Coumestans from
Lespedeza bicolor
. 3167 25
