Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.4.2.30 (
PARP
)
13,611
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The steady-state levels of mRNA for the poly(ADP-ribose)polymerase (
PARP
), c-myc, p53, and histone H3 genes were investigated in 31 high-grade B-cell lymphomas by northern blot analysis. The panel included 15 nodal large B-cell lymphomas, nine mediastinal large B-cell lymphomas, and seven sporadic Burkitt's lymphomas. The
PARP
mRNA level was significantly higher in lymphomas than in control tissues and corresponded with the amount of
PARP
protein, as assessed by immunoblot analysis in six samples. The level of
PARP
mRNA was positively correlated with that of p53 mRNA. No correlation was found between the mRNA expression levels of
PARP
and histone H3, suggesting that
PARP
expression levels are independent of the proliferation rate of neoplastic cells. In this setting, the strong correlation between
PARP
and p53 suggests that the high expression of
PARP
may be associated with ongoing DNA damage in
high-grade lymphomas
.
...
PMID:Correlation of poly(ADP-ribose)polymerase and p53 expression levels in high-grade lymphomas. 1044 32
