Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.3.3.1 (citrate synthase)
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Human Gene/Protein
citrate synthase 12.8
MO25 protein 12.8
mitochondrial ribosomal protein L48 12.8
Calcineurin catalytic subunit 11.8
NADH dehydrogenase flavoprotein 1 11.8
pentatricopeptide repeat domain 3 11.8
URK1 11.8
METTL12 11.8
Citrate synthase 11.5
ATP synthase D chain, mitochondrial 11.2
myosin-Ic 10.8
SDHA protein 10.8
ACTIN-2 10.8
pyruvate carboxylase, mitochondrial 10.8
ATP5J2 10.5
collagen, type IV, alpha 1 10.5
3-hydroxyacyl-CoA dehydrogenase 10.3
CCL11 protein 10.2
PFK-P 10.2
Myokinase 10.2
aconitate hydratase 10.1
dihydrolipoamide S-succinyltransferase 10.0
KAS I 9.9
NRF1 protein 9.8
FOX3 9.8
transcription factor NRF 9.8
COXIV 9.7
fumarase 9.7
NAD+-isocitrate dehydrogenase 9.6
HAD 9.5
peroxisomal biogenesis factor 9.5
nuclear respiratory factor-1 9.5
3-hydroxybutyrate dehydrogenase 9.4
COX5B 9.4
NAD-IDH 9.4
isocitric dehydrogenase 9.4
malate dehydrogenase 9.4
HOX1 9.3
HSD-3.8 9.3
UQCRH 9.3
glycerol-3-phosphate dehydrogenase 2 9.3
MHC IIa 9.3
aconitase 9.2
GPX4 protein 9.2
cytochrome c oxidase assembly protein 9.2
LW-1 9.2
RUN2 9.2
microtubule-associated proteins 1A/1B light chain 3 9.2
mitochondrial malate dehydrogenase 9.2
alpha-ketoglutarate dehydrogenase 9.2
NADP-dependent isocitrate dehydrogenase 9.1
COX4 9.1
DRC3 9.1
v-myc myelocytomatosis viral oncogene homolog 9.1
COX8 9.1
tribbles 3 9.1
nuclear respiratory factor 1 9.1
6-phosphofructokinase 9.0
isocitrate dehydrogenase 9.0
mtTFA 9.0
COX5A 9.0
phosphofructokinase 9.0
Protein disulfide-isomerase 9.0
succinate dehydrogenase flavoprotein subunit 9.0
Atp12p 9.0
cytosolic malate dehydrogenase 8.9
FEEL-1 8.9
PHF20 8.9
Acetyl-CoA hydrolase 8.9
NRF-1 8.9
transcription factor A, mitochondrial 8.9
COX IV 8.9
ACADVL 8.8
mitochondrial transcription factor A 8.8
ankyrin-related 8.8
TMEM26 8.8
monocarboxylic acid transporter 1 8.8
NRF-2 8.8
GSD1a 8.8
AIP2 8.8
more...
Disease
Citrate toxicity 10.8
Steroid-induced diabetes 10.2
HPLE 10.2
North Asian tick typhus 9.3
CIIP 9.0
spotted fever 8.5
bartonellosis 8.3
Richner-Hanhart syndrome 8.2
Brazilian spotted fever 8.1
mite-borne 8.0
Ehrlichia canis infection 7.9
Murine typhus 7.7
MGA3 7.6
Muscle degeneration 7.6
rickettsiosis 7.2
typhus 7.1
Mitochondrial DNA depletion 7.0
Klebs 7.0
KCS 7.0
Bladder outlet obstruction 6.7
heritable connective tissue disorder 6.6
histidinemia 6.6
Staphylococcus aureus pneumonia 6.6
Carnitine deficiency 6.6
Bergeron 6.6
Diaphragm 6.6
MCAD deficiency 6.6
CCV 6.5
SPG7 6.5
OPA1 6.4
Hyperamylasemia 6.3
Bed bugs 6.1
alcoholic myopathy 6.1
MERRF 6.1
Kearns-Sayre syndrome 6.1
chigger 6.0
TYPE 6.0
mitochondrial disease 5.9
MELAS 5.9
X-linked sideroblastic anemia 5.9
mitochondrial myopathy 5.9
Jejunum 5.7
trench fever 5.7
MELAS 5.6
tyrosinemia 5.5
hereditary ataxia 5.4
SM1 5.4
human granulocytic ehrlichiosis 5.4
glutaric aciduria 5.3
Leigh syndrome 5.3
gingivostomatitis 5.2
Crabs 5.2
paramyotonia 5.1
propionic acidemia 5.0
cardiac overload 5.0
olivopontocerebellar atrophy 4.9
MCS 4.9
MCS 4.8
Barth syndrome 4.8
IDD 4.8
Cat scratch disease 4.8
AHL 4.8
Friedreich's ataxia 4.8
Chronic heart failure 4.7
acute cystitis 4.7
Chimera 4.5
Rocky Mountain spotted fever 4.5
Mediterranean spotted fever 4.5
alcoholic cardiomyopathy 4.4
ACP 4.4
Goldblatt 4.4
ehrlichiosis 4.4
methylmalonic acidemia 4.4
lactic acidosis 4.3
overnutrition 4.3
Acute liver failure 4.3
PCS 4.3
PAL 4.3
lipoatrophy 4.3
Murray Valley encephalitis 4.2
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Symptom
Diaphragmatic weakness 8.5
Fatigability 6.8
loss of equilibrium 6.7
Exercise intolerance 5.9
physical exhaustion 5.4
Deafferentation 5.4
Tenderness 5.2
Extrapyramidal symptoms 5.2
exhaustion 4.8
male subfertility 4.7
Catch 3.8
ataxic gait 3.7
cachexia 3.5
fatigue 3.4
hyperoxia 3.3
ophthalmoplegia 3.1
DNA marker 2.9
starvation 2.8
fever of unknown origin 2.8
chorea 2.8
hepatomegaly 2.6
hypotonia 2.6
muscle stiffness 2.5
myalgia 2.4
nasal discharge 2.4
weakness 2.2
acute stress 2.2
functional recovery 1.9
hypercapnia 1.8
overweight 1.6
pallor 1.5
ataxia 1.4
lethargy 1.3
acidity 1.2
spasticity 1.1
hypothermia 1.0
arthralgia 1.0
cyanosis 0.9
agitation 0.8
pelvic pain 0.8
paresis 0.3
tremor 0.2
seizures 0.1
anorexia 0.0
spasm -0.1
low back pain -0.5
thinning -0.7
erythema -0.9
dyspnea -1.0
headache -1.0
collapse -1.0
vomiting -1.2
angina -1.6
anesthesia -1.6
nausea -1.7
abdominal pain -2.1
pain -2.6
diarrhea -3.0
Drug
Haloperidol Decanoate 10.2
Oxfenicine 8.4
Protein hydrolysate 7.9
Naftidrofuryl 7.5
Cimaterol 7.4
Amlexanox 7.3
Activase 7.2
CMX 7.0
Atabrine 6.9
citric acid 6.8
Trifluoroethanol 6.5
TMX 6.5
3,4-Dihydroxyphenylalanine 6.5
NADH 6.1
Citric acid 5.8
CEX 5.7
RBT 5.6
Perindopril 5.4
3-Methyladenine 5.4
Clofibrate 5.2
Micafungin 5.1
Cytidine 4.9
Papaverine 4.9
CSI 4.9
Kaolin 4.9
Rasburicase 4.8
VCR 4.8
Parkin 4.7
Parkin 4.7
Bezafibrate 4.7
Sodium valproate 4.5
Colombo 4.4
Artesunate 4.4
K-252a 4.4
Fulvestrant 4.3
Tao 4.2
SMP 4.2
Rosiglitazone 4.1
Aminoguanidine 4.1
ddI 4.0
Adenosine triphosphate 4.0
ISP 3.9
Salicylate 3.7
Coral 3.2
L-tyrosine 3.2
ROS 3.1
Simvastatin 3.1
Glutathione 3.0
Photofrin 2.9
Fructose 2.9
Asn 2.9
Growth hormone 2.8
Growth hormone 2.8
EPI 2.7
Doxycycline 2.7
Captopril 2.6
Vitamin B12 2.5
Methylene blue 2.5
Nitric Oxide 2.4
ETS 2.4
AZT 2.4
FAD 2.4
Portal 2.3
Prednisolone 2.3
Gel 2.3
Sorafenib 2.2
AZT 2.2
MgSO4 2.2
Bayer 2.2
Acacia 2.1
Ginseng 2.1
Diurnal 2.0
Kenyan 2.0
lysine 2.0
vitamin E 1.9
Check 1.8
DNase I 1.8
ascorbate 1.8
TMS 1.6
Leaf 1.4
more...
Enzyme
oleate Delta12-hydroxylase 12.8
citrate synthase 12.8
condensing enzyme 11.9
citryl-CoA lyase 11.7
calpain A 11.2
PEP phosphatase 11.0
citrate lyase deacetylase 10.8
3-hydroxyacyl-CoA dehydrogenase 10.7
3-hydroxyacyl-CoA dehydrogenase 10.5
CimA 10.5
citryl-CoA synthetase 10.5
calpain B 10.2
trans-2-enoyl-CoA reductase 10.1
oxoglutarate dehydrogenase 10.1
citramalate synthase 10.0
glycerophosphate phosphatase 10.0
strombine dehydrogenase 9.8
FabF 9.8
2-oxoglutarate decarboxylase 9.5
malate synthase 9.5
citrate lyase 9.4
FabH 9.3
aconitase 9.3
valine dehydrogenase 9.3
alpha-ketoglutarate dehydrogenase 9.3
fumarase 9.2
FabM 9.2
aspartate N-acetyltransferase 9.2
3-oxoacid CoA-transferase 9.2
malate dehydrogenase 9.2
acetoacetyl-CoA reductase 9.1
isocitrate dehydrogenase 9.1
acetyl-CoA hydrolase 9.0
tauropine dehydrogenase 9.0
phosphofructokinase 8.9
isocitrate dehydrogenase 8.9
carnitine acetyltransferase 8.9
homocitrate synthase 8.6
acyl-CoA dehydrogenase 8.6
fatty acid elongase 8.6
acetate CoA-transferase 8.6
succinyl-CoA synthetase 8.6
beta-hydroxybutyrate dehydrogenase 8.6
malate oxidase 8.5
hexokinase 8.5
malyl-CoA lyase 8.5
alpha-isopropylmalate synthase 8.4
acyl-CoA dehydrogenase 8.4
pyruvate carboxylase 8.4
isocitrate lyase 8.4
PrpD 8.3
EC 1.1.1.38 8.3
acyl carrier protein synthase 8.3
BCKDH 8.3
dihydrolipoamide succinyltransferase 8.2
succinate dehydrogenase 8.2
3-hydroxybutyryl-CoA dehydrogenase 8.1
citrate cleavage enzyme 8.1
riboflavin synthase 8.0
pyruvate dehydrogenase 7.9
pyruvate dehydrogenase 7.9
isopropylmalate isomerase 7.9
pyruvate kinase 7.9
cytochrome oxidase 7.8
DHAD 7.8
acetyl-CoA synthetase 7.8
pyruvate:ferredoxin oxidoreductase 7.8
phosphoenolpyruvate synthase 7.7
10-formyltetrahydrofolate dehydrogenase 7.7
propionyl-CoA synthetase 7.7
phosphoenolpyruvate carboxylase 7.6
pyruvate dehydrogenase 7.6
malonyl-CoA decarboxylase 7.6
EC 4.4.1.5 7.5
branched-chain aminotransferase 7.5
octopine dehydrogenase 7.5
aspartyl aminopeptidase 7.5
acetylornithine aminotransferase 7.5
acetoacetyl-CoA synthetase 7.5
nicotinamide adenine dinucleotide glycohydrolase 7.5
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Compound
Trifluoroacetonylmercaptoethanol 12.8
Ubisemiquinone 11.8
2,4-Dihydroxyquinoline 11.2
Citramalate 10.8
Citramalate 10.8
Methylcitric acid 10.7
Ethylmalonic acid 10.5
T 78 10.5
Mersalyl acid 10.0
Thiolactomycin 9.9
malyl-CoA 9.6
C4H6O6 9.3
2-methylcitric acid 9.2
ethyl 3,4-dihydroxybenzoate 9.0
2,3-naphthalenediol 8.9
PDAP 8.9
MB 1 8.8
propionyl-coenzyme A 8.7
oxalacetate 8.6
2-keto-4-hydroxyglutarate 8.6
1,2,3-benzenetricarboxylic acid 8.5
2,5-pyrrolidinedione 8.5
Phenylpyruvate 8.4
3-methyl-2-oxopentanoate 8.3
3-HP 8.3
Homocitrate 8.3
Cyprodinil 8.1
acetyl-CoA 8.1
alpha-isopropylmalate 8.1
isocitrate 7.9
15(S)-HPETE 7.6
CoA 7.5
Novex 7.5
Pyruvate kinase 7.4
4-methylpentanoic acid 7.3
Succinimide 7.3
Geraniin 7.3
L-methylmalonyl-CoA 7.2
2-chloroacetamide 7.2
acetoacetyl-CoA 7.1
Cetylpyridinium chloride 7.1
palmitoyl-CoA 7.1
2-oxoglutarate 7.0
Benzamil 6.9
KIV 6.9
L-chicoric acid 6.9
Malate 6.8
3'-amino-3'-deoxythymidine 6.8
trimethyllysine 6.8
fluoroacetic acid 6.7
Cerulenin 6.7
Phloroglucinol 6.7
Cyclopiazonic acid 6.6
4-hydroxy-3-methoxybenzaldehyde 6.6
4-hydroxy-3-methoxybenzaldehyde 6.6
Acetyl phosphate 6.6
2-Oxoglutarate 6.6
TLL 6.6
linoleoyl-CoA 6.6
CIT 6.6
Bilobalide 6.6
Erythritol 6.6
malonyl-CoA 6.6
Phloroglucinol 6.5
Propyl gallate 6.5
FK520 6.5
Succinyl-CoA 6.5
Phytanic acid 6.5
D-Glyceraldehyde 6.4
Cetylpyridinium chloride 6.4
docosanoic acid 6.4
COX 6.4
Nandrolone 6.4
MNE 6.4
Guanidinoacetic acid 6.3
PDH 6.3
octanoyl-CoA 6.3
MTU 6.2
TCA 6.2
5-fluorotryptophan 6.2
more...