Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.3.3.1 (citrate synthase)
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Human Gene/Protein
mitochondrial ribosomal protein L48 12.8
citrate synthase 12.8
MO25 protein 12.8
URK1 11.8
METTL12 11.8
NADH dehydrogenase flavoprotein 1 11.8
Calcineurin catalytic subunit 11.8
pentatricopeptide repeat domain 3 11.8
Citrate synthase 11.5
ATP synthase D chain, mitochondrial 11.2
ACTIN-2 10.8
myosin-Ic 10.8
pyruvate carboxylase, mitochondrial 10.8
SDHA protein 10.8
ATP5J2 10.5
collagen, type IV, alpha 1 10.5
3-hydroxyacyl-CoA dehydrogenase 10.3
PFK-P 10.2
Myokinase 10.2
CCL11 protein 10.2
aconitate hydratase 10.1
dihydrolipoamide S-succinyltransferase 10.0
KAS I 9.9
NRF1 protein 9.8
transcription factor NRF 9.8
FOX3 9.8
COXIV 9.7
fumarase 9.7
NAD+-isocitrate dehydrogenase 9.6
HAD 9.5
peroxisomal biogenesis factor 9.5
nuclear respiratory factor-1 9.5
3-hydroxybutyrate dehydrogenase 9.4
COX5B 9.4
NAD-IDH 9.4
isocitric dehydrogenase 9.4
malate dehydrogenase 9.4
HSD-3.8 9.3
glycerol-3-phosphate dehydrogenase 2 9.3
HOX1 9.3
more...
Disease
Citrate toxicity 10.8
HPLE 10.2
Steroid-induced diabetes 10.2
North Asian tick typhus 9.3
CIIP 9.0
spotted fever 8.5
bartonellosis 8.3
Richner-Hanhart syndrome 8.2
Brazilian spotted fever 8.1
mite-borne 8.0
Ehrlichia canis infection 7.9
Murine typhus 7.7
MGA3 7.6
Muscle degeneration 7.6
rickettsiosis 7.2
typhus 7.1
Mitochondrial DNA depletion 7.0
Klebs 7.0
KCS 7.0
Bladder outlet obstruction 6.7
heritable connective tissue disorder 6.6
histidinemia 6.6
Staphylococcus aureus pneumonia 6.6
Bergeron 6.6
Carnitine deficiency 6.6
Diaphragm 6.6
MCAD deficiency 6.6
CCV 6.5
SPG7 6.5
OPA1 6.4
Hyperamylasemia 6.3
Bed bugs 6.1
alcoholic myopathy 6.1
MERRF 6.1
Kearns-Sayre syndrome 6.1
chigger 6.0
TYPE 6.0
mitochondrial disease 5.9
MELAS 5.9
X-linked sideroblastic anemia 5.9
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Symptom
Diaphragmatic weakness 8.5
Fatigability 6.8
loss of equilibrium 6.7
Exercise intolerance 5.9
physical exhaustion 5.4
Deafferentation 5.4
Tenderness 5.2
Extrapyramidal symptoms 5.2
exhaustion 4.8
male subfertility 4.7
Catch 3.8
ataxic gait 3.7
cachexia 3.5
fatigue 3.4
hyperoxia 3.3
ophthalmoplegia 3.1
DNA marker 2.9
starvation 2.8
fever of unknown origin 2.8
chorea 2.8
hepatomegaly 2.6
hypotonia 2.6
muscle stiffness 2.5
myalgia 2.4
nasal discharge 2.4
weakness 2.2
acute stress 2.2
functional recovery 1.9
hypercapnia 1.8
overweight 1.6
pallor 1.5
ataxia 1.4
lethargy 1.3
acidity 1.2
spasticity 1.1
hypothermia 1.0
arthralgia 1.0
cyanosis 0.9
agitation 0.8
pelvic pain 0.8
more...
Drug
Haloperidol Decanoate 10.2
Oxfenicine 8.4
Protein hydrolysate 7.9
Naftidrofuryl 7.5
Cimaterol 7.4
Amlexanox 7.3
Activase 7.2
CMX 7.0
Atabrine 6.9
citric acid 6.8
Trifluoroethanol 6.5
TMX 6.5
3,4-Dihydroxyphenylalanine 6.5
NADH 6.1
Citric acid 5.8
CEX 5.7
RBT 5.6
Perindopril 5.4
3-Methyladenine 5.4
Clofibrate 5.2
Micafungin 5.1
Cytidine 4.9
Papaverine 4.9
CSI 4.9
Kaolin 4.9
Rasburicase 4.8
VCR 4.8
Parkin 4.7
Parkin 4.7
Bezafibrate 4.7
Sodium valproate 4.5
Colombo 4.4
Artesunate 4.4
K-252a 4.4
Fulvestrant 4.3
Tao 4.2
SMP 4.2
Rosiglitazone 4.1
Aminoguanidine 4.1
ddI 4.0
more...
Enzyme
oleate Delta12-hydroxylase 12.8
citrate synthase 12.8
condensing enzyme 11.9
citryl-CoA lyase 11.7
calpain A 11.2
PEP phosphatase 11.0
citrate lyase deacetylase 10.8
3-hydroxyacyl-CoA dehydrogenase 10.7
3-hydroxyacyl-CoA dehydrogenase 10.5
CimA 10.5
citryl-CoA synthetase 10.5
calpain B 10.2
trans-2-enoyl-CoA reductase 10.1
oxoglutarate dehydrogenase 10.1
citramalate synthase 10.0
glycerophosphate phosphatase 10.0
strombine dehydrogenase 9.8
FabF 9.8
2-oxoglutarate decarboxylase 9.5
malate synthase 9.5
citrate lyase 9.4
FabH 9.3
aconitase 9.3
valine dehydrogenase 9.3
alpha-ketoglutarate dehydrogenase 9.3
fumarase 9.2
aspartate N-acetyltransferase 9.2
FabM 9.2
3-oxoacid CoA-transferase 9.2
malate dehydrogenase 9.2
acetoacetyl-CoA reductase 9.1
isocitrate dehydrogenase 9.1
acetyl-CoA hydrolase 9.0
tauropine dehydrogenase 9.0
phosphofructokinase 8.9
isocitrate dehydrogenase 8.9
carnitine acetyltransferase 8.9
homocitrate synthase 8.6
acyl-CoA dehydrogenase 8.6
fatty acid elongase 8.6
more...
Compound
Trifluoroacetonylmercaptoethanol 12.8
Ubisemiquinone 11.8
2,4-Dihydroxyquinoline 11.2
Citramalate 10.8
Citramalate 10.8
Methylcitric acid 10.7
T 78 10.5
Ethylmalonic acid 10.5
Mersalyl acid 10.0
Thiolactomycin 9.9
malyl-CoA 9.6
C4H6O6 9.3
2-methylcitric acid 9.2
ethyl 3,4-dihydroxybenzoate 9.0
2,3-naphthalenediol 8.9
PDAP 8.9
MB 1 8.8
propionyl-coenzyme A 8.7
oxalacetate 8.6
2-keto-4-hydroxyglutarate 8.6
2,5-pyrrolidinedione 8.5
1,2,3-benzenetricarboxylic acid 8.5
Phenylpyruvate 8.4
3-methyl-2-oxopentanoate 8.3
Homocitrate 8.3
3-HP 8.3
Cyprodinil 8.1
acetyl-CoA 8.1
alpha-isopropylmalate 8.1
isocitrate 7.9
15(S)-HPETE 7.6
CoA 7.5
Novex 7.5
Pyruvate kinase 7.4
4-methylpentanoic acid 7.3
Succinimide 7.3
Geraniin 7.3
L-methylmalonyl-CoA 7.2
2-chloroacetamide 7.2
acetoacetyl-CoA 7.1
more...