Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.3.3.1 (citrate synthase)
 4,488 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
citrate synthase 4253
lactate dehydrogenase 552
ATP 443
malate dehydrogenase 345
Mol 335
Sep 290
insulin 287
hexokinase 266
cytochrome c oxidase 255
phosphofructokinase 247
isocitrate dehydrogenase 216
NADH 213
pyruvate kinase 171
PGC 145
ATPase 143
aconitase 138
Citrate synthase 137
creatine kinase 135
catalase 124
pyruvate dehydrogenase 121
superoxide dismutase 120
ADP 113
3-hydroxyacyl-CoA dehydrogenase 98
NAD 95
myosin heavy chain 91
TCA 91
cytochrome c 89
glutamate dehydrogenase 87
fumarase 86
glucose-6-phosphate dehydrogenase 81
cytochrome 79
aspartate aminotransferase 78
peroxisome proliferator-activated receptor 76
pyruvate carboxylase 69
AMP 67
LDH 67
myosin 62
glutathione peroxidase 59
peroxisome proliferator-activated receptor gamma 57
membrane protein 53
alpha-ketoglutarate dehydrogenase 52
NMR 52
heat shock protein 51
HAD 51
myoglobin 49
CO2 48
AMPK 48
NADP 46
AMP-activated protein kinase 44
crystallin 44
acyl-CoA dehydrogenase 44
GLUT4 43
mitochondrial transcription factor A 43
fatty acid synthase 42
phosphoenolpyruvate carboxylase 42
NAD+ 41
glucose transporter 41
carnitine palmitoyltransferase 40
endoplasmic reticulum 40
reductase 39
TFAM 38
glycogen phosphorylase 38
COX 37
cardiac muscle 37
dimeric 37
glycolytic enzyme 36
ATP synthase 35
hemoglobin 34
SDS 34
Pseudomonas 33
alcohol dehydrogenase 32
AED 32
NADPH 32
pyruvate dehydrogenase complex 31
phosphoenolpyruvate carboxykinase 31
CD36 31
polypeptide 30
alanine aminotransferase 30
UCP3 30
GLUT-4 30
2-oxoglutarate dehydrogenase 29
GSH 29
acetyl-CoA carboxylase 28
adenylate kinase 28
antioxidant enzyme 27
glyceraldehyde-3-phosphate dehydrogenase 27
ACL 27
oxidoreductase 26
carnitine acetyltransferase 25
nitric oxide synthase 25
chaperonin 24
glycogen synthase 24
ROS 24
mitochondrial malate dehydrogenase 24
SOD 23
HSP70 23
MnSOD 23
lipoamide dehydrogenase 23
COXIV 23
glutaminase 22
Hsp90 22
glutamine synthetase 22
lipoprotein lipase 22
cage 22
6-phosphofructokinase 21
muscle protein 21
Gen 21
epididymal 21
NADP-dependent isocitrate dehydrogenase 20
nuclear respiratory factor 1 20
leptin 20
NADP+ 19
membrane-bound 19
microsomal 19
FAT 19
glutathione reductase 19
caspase-3 18
phosphorylating 18
6-phosphogluconate dehydrogenase 18
LL) 18
CPT 18
aconitate hydratase 18
PPAR 17
Hexokinase 17
Cytochrome c 17
mtTFA 17
Bcl-2 17
long chain 17
manganese superoxide dismutase 17
beta-glucuronidase 17
NADH dehydrogenase 17
carnitine palmitoyltransferase I 17
MDH 17
mTOR 16
SIRT1 16
enolase 16
cytochrome b 16
sirtuin 1 16
isocitric dehydrogenase 16
nuclear respiratory factor-1 16
NRF-1 16
lipopolysaccharide 15
Pyruvate dehydrogenase 15
glycerol-3-phosphate dehydrogenase 15
proteasome 15
peroxidase 15
thyroid hormone 15
fatty acid binding protein 15
fatty acid translocase 15
glutathione S-transferase 15
glucagon 14
ubiquitin 14
ATP citrate lyase 14
threonine 14
TNF 14
acetylcholinesterase 14
rhodanese 14
p38 13
MHC IIa 13
vascular endothelial growth factor 13
more...
Disease
obesity 110
cold 95
diabetes 94
spotted fever 69
heart failure 48
type 2 diabetes 45
cancer 43
ischemia 43
SDS 34
GSH 29
myopathy 28
tumor 27
Alzheimer's disease 24
depression 23
typhus 22
stroke 22
chronic obstructive pulmonary disease 21
Parkinson's disease 19
hyperglycemia 17
muscular atrophy 17
myocardial infarction 16
rickettsiosis 16
fatty liver 16
Mycobacterium 16
Evans 16
mitochondrial disease 16
hypertension 15
bartonellosis 15
ventricular hypertrophy 15
Brown 15
hyperthyroidism 13
cardiomyopathy 13
tuberculosis 13
glucose intolerance 13
amyotrophic lateral sclerosis 13
hyperinsulinemia 12
lactic acidosis 12
hypothyroidism 12
endocarditis 12
cardiovascular disease 11
sepsis 11
encephalopathy 10
sepsis 10
heart disease 10
malnutrition 10
dehydration 9
infectious diseases 9
FAS 9
Huntington's disease 9
ACP 9
Duchenne muscular dystrophy 9
mitochondrial myopathy 9
bacteremia 9
bipolar disorder 9
Leigh syndrome 8
Mycoplasma 8
iron deficiency 8
OPA1 8
epilepsy 8
anemia 8
Friedreich's ataxia 8
wasting 8
metabolic syndrome 8
immunodeficiency 8
myocardial ischemia 8
pheochromocytoma 8
HIV 8
NAME 7
congestive heart failure 7
dilated cardiomyopathy 7
neuroblastoma 7
SEM 7
carcinoma 7
Diaphragm 7
hypoglycemia 6
Kearns-Sayre syndrome 6
carcinogenesis 6
neuropathy 6
Infection 6
PCC 6
malaria 6
lice 6
liver disease 5
mania 5
mental retardation 5
muscular dystrophy 5
Chagas 5
zoonosis 5
mental retardation 5
mole 5
mole 5
MRS 5
fits 5
type 1 diabetes 5
coronary artery disease 5
Pineal 5
phenylketonuria 5
chronic renal failure 5
hepatitis 5
breast cancer 5
HSP 5
B-cell lymphoma 4
DBA 4
sickle cell disease 4
tyrosinemia 4
movement disorder 4
astrocytoma 4
mitral regurgitation 4
proteinuria 4
dementia 4
Poland 4
ketosis 4
autism 4
autoimmune disease 4
thyrotoxicosis 4
pneumonia 4
MELAS 4
claudication 4
dyslipidemia 4
MELAS 4
cataract 4
rash 4
hepatocellular carcinoma 4
Klebsiella 4
tumor growth 4
tumor progression 4
cirrhosis 3
Legionella 3
chronic fatigue syndrome 3
dysphagia 3
worms 3
arthritis 3
AIDS 3
fungal infection 3
lung disease 3
hyperlipidemia 3
MCS 3
Richner-Hanhart syndrome 3
IBM 3
hypercholesterolemia 3
encephalitis 3
adenocarcinoma 3
MCF 3
peripheral neuropathy 3
myocarditis 3
ventricular septal defect 3
Conn 3
preeclampsia 3
metabolic disorder 3
MCS 3
glioma 3
glioblastoma 3
CCD 3
thrombocytopenia 3
osteoarthritis 3
neuromuscular disorder 3
polio 3
hypertrophic cardiomyopathy 3
vitamin D deficiency 3
ehrlichiosis 3
more...
Symptom
fatigue 78
exhaustion 55
weakness 25
starvation 24
seizures 12
overweight 11
cachexia 9
hyperoxia 7
functional recovery 7
ataxia 6
pain 6
hypothermia 5
hepatomegaly 5
anesthesia 5
acidity 5
myalgia 5
hypotonia 5
ophthalmoplegia 4
hypercapnia 4
headache 4
agitation 3
tremor 3
acute stress 3
loss of equilibrium 2
Tenderness 2
chorea 2
anorexia 2
dyspnea 2
spasticity 2
lethargy 2
vomiting 2
collapse 2
fever of unknown origin 2
arthralgia 2
nausea 1
physical exhaustion 1
Exercise intolerance 1
muscle stiffness 1
male subfertility 1
cyanosis 1
ataxic gait 1
diarrhea 1
thinning 1
Extrapyramidal symptoms 1
DNA marker 1
erythema 1
Diaphragmatic weakness 1
pallor 1
low back pain 1
paresis 1
spasm 1
pelvic pain 1
Fatigability 1
nasal discharge 1
Deafferentation 1
abdominal pain 1
angina 1
Catch 1
Drug
NADH 215
citric acid 158
lysine 32
ROS 24
Asn 12
ascorbate 11
Gel 10
vitamin E 9
Leaf 8
Parkin 7
Parkin 7
Cardiovasc 7
VCR 6
Glutathione 6
lactose 5
DNase I 4
Citric acid 4
FAD 4
Growth hormone 3
Portal 3
Ethanol 3
caffeine 3
Growth hormone 3
L-tyrosine 3
Clofibrate 3
CMX 2
Biopolymers 2
ETS 2
Nitric Oxide 2
AZT 2
EPI 2
NH3 2
CAM 2
Kenyan 2
Fructose 2
Papaverine 2
Naftidrofuryl 2
Coral 2
Simvastatin 2
EPA 2
PTH 2
Rosiglitazone 2
AZT 2
Adenosine triphosphate 2
Captopril 2
Perindopril 2
CSI 2
ETA 1
Alanine 1
Tao 1
Photofrin 1
Dermatol 1
CEX 1
MAP 1
Haloperidol Decanoate 1
EE2 1
RBT 1
Fluorescein 1
Cytidine 1
Oxfenicine 1
Atabrine 1
Mutagen 1
Spectrum 1
CaCl2 1
Fulvestrant 1
Vitamin B12 1
Methylene blue 1
Monit 1
ddI 1
CaCl2 1
CSF 1
Acacia 1
Doxycycline 1
Cimaterol 1
ISP 1
Amlexanox 1
Colombo 1
Ginseng 1
Prednisolone 1
Artesunate 1
CaCl2 1
Check 1
Activase 1
Bayer 1
Protein hydrolysate 1
ALA 1
K-252a 1
Glucagon 1
TMS 1
3-Methyladenine 1
ICI 1
Sodium valproate 1
ABC 1
TMX 1
Heme 1
Rasburicase 1
MgSO4 1
3,4-Dihydroxyphenylalanine 1
MRC 1
Sorafenib 1
Spectrum 1
nitroglycerin 1
Bezafibrate 1
Salicylate 1
Kaolin 1
Trifluoroethanol 1
Diurnal 1
Aminoguanidine 1
Micafungin 1
SMP 1
Nephron 1
ampicillin 1
Enzyme
citrate synthase 4488
lactate dehydrogenase 572
malate dehydrogenase 369
succinate dehydrogenase 328
cytochrome oxidase 281
hexokinase 266
phosphofructokinase 265
isocitrate dehydrogenase 235
isocitrate dehydrogenase 233
ATPase 177
pyruvate kinase 171
complex I 166
3-hydroxyacyl-CoA dehydrogenase 157
aconitase 156
creatine kinase 154
pyruvate dehydrogenase 150
condensing enzyme 148
3-hydroxyacyl-CoA dehydrogenase 144
superoxide dismutase 135
catalase 127
pyruvate dehydrogenase 120
pyruvate dehydrogenase 120
alpha-ketoglutarate dehydrogenase 111
glucose-6-phosphate dehydrogenase 99
fumarase 95
AMP-activated protein kinase 88
glutamate dehydrogenase 87
glutamate dehydrogenase 87
glutamate dehydrogenase 87
diaphorase 80
phosphorylase 80
aspartate aminotransferase 79
phosphoenolpyruvate carboxykinase 76
phosphoenolpyruvate carboxykinase 75
phosphoenolpyruvate carboxykinase 75
pyruvate carboxylase 71
acyl-CoA dehydrogenase 68
CPT 67
CPR 61
glutathione peroxidase 60
glyceraldehyde-3-phosphate dehydrogenase 56
glyceraldehyde-3-phosphate dehydrogenase 55
malate synthase 51
AMPK 49
AMPK 48
phosphoenolpyruvate carboxylase 47
isocitrate lyase 46
glyceraldehyde-3-phosphate dehydrogenase 45
acyl-CoA dehydrogenase 44
alanine aminotransferase 42
glycerol-3-phosphate dehydrogenase 42
glycerol-3-phosphate dehydrogenase 42
glyceraldehyde-3-phosphate dehydrogenase 41
ATP synthase 40
alcohol dehydrogenase 34
adenylate kinase 33
succinic dehydrogenase 32
acetyl-CoA carboxylase 29
aldolase 29
carnitine acetyltransferase 28
citrate lyase 27
glyceraldehyde-3-phosphate dehydrogenase 27
luciferase 27
diaphorase 26
oxoglutarate dehydrogenase 25
RNA polymerase 25
ACS 25
protein kinase 24
chaperonin 24
glutaminase 23
SCS 23
succinyl-CoA synthetase 22
glutamine synthetase 22
lipoprotein lipase 22
glutathione reductase 21
beta-hydroxybutyrate dehydrogenase 20
acyl-CoA synthetase 20
FabH 20
mitogen-activated protein kinase 19
trypsin 19
6-phosphogluconate dehydrogenase 19
6-phosphogluconate dehydrogenase 19
glutathione S-transferase 19
CPT 18
proteasome 18
CPT 18
MDH 17
NADH dehydrogenase 17
beta-glucuronidase 17
MDH 17
enolase 17
peroxidase 16
myosin ATPase 15
PTA 15
MCS 15
NO synthase 14
alpha-glucosidase 14
fatty acid elongase 14
rhodanese 14
lactic acid dehydrogenase 14
acetyl-CoA synthetase 14
FabF 14
KAT 14
lipase 13
lysozyme 13
acetylcholinesterase 13
caspase-3 12
glucokinase 12
ACE 12
reverse transcriptase 12
phosphoglucose isomerase 12
choline acetyltransferase 12
PDK1 11
PDH 11
acetate kinase 11
acetoacetyl-CoA reductase 11
peptidyl-prolyl cis-trans isomerase 10
chymotrypsin 10
phosphoglycerate kinase 10
ECH 10
calcineurin 10
hormone-sensitive lipase 9
ERK 9
fumarate reductase 9
acyl carrier protein synthase 9
RNase 9
RNase 9
peroxiredoxin 8
glutamate synthase 8
3-oxoacid CoA-transferase 8
acetoacetyl-CoA thiolase 8
glucose-6-phosphatase 8
acid phosphatase 8
PRE 8
alkaline phosphatase 8
subtilisin 7
glutamate synthase 7
NADPH oxidase 7
endonuclease 7
glutamate decarboxylase 7
beta-galactosidase 7
glutamate synthase 7
ALA synthase 7
carbonic anhydrase 7
monoamine oxidase 7
aspartokinase 7
pyruvate:ferredoxin oxidoreductase 7
acyl-CoA synthetase 7
tyrosine aminotransferase 6
firefly luciferase 6
acyl-CoA oxidase 6
arginase 6
branched-chain aminotransferase 6
invertase 6
NADPH oxidase 6
glycolate oxidase 6
nitrate reductase 6
NOS 6
threonine deaminase 6
reductoisomerase 6
more...
Compound
glucose 634
oxygen 523
ATP 443
DNA 438
CoA 390
Dec 348
acetyl-CoA 217
NADH 215
phosphate 184
glutamate 184
acetate 164
water 157
2-oxoglutarate 138
NAD 134
ADP 123
Clin 117
ADP 114
ADP 113
NAD 95
TCA 94
calcium 92
sodium 83
nitrogen 80
alanine 77
AMP 73
NADP 69
CO2 65
hydrogen 64
glutamine 61
glycerol 60
arginine 57
isocitrate 57
iron 51
phosphocreatine 48
serine 47
cysteine 44
ethanol 43
oxalacetate 42
urea 42
leucine 41
lysine 40
His 39
nicotinamide 39
SDS 38
CIT 38
salt 37
Lactate 37
COX 37
nitric oxide 36
Cardiol 36
NADPH 34
GSH 33
Insulin 33
GSH 33
NADPH 32
alcohol dehydrogenase 32
ammonium 32
pentose 31
pentose 31
palmitoyl-CoA 31
pentose 31
ammonia 31
pentose 31
acetic acid 29
methionine 27
sulfate 26
Asp 26
malonyl-CoA 25
copper 25
L-carnitine 25
succinic acid 24
H2O2 24
proline 23
glucose-6-phosphate 22
aluminum 20
Glycogen 20
Phe 20
malic acid 20
Mg2+ 19
aspartic acid 19
CPT 18
threonine 18
tyrosine 18
CPT 18
potassium 17
Gly 17
Ile 17
palmitic acid 17
Cytochrome c 17
Pyruvate 17
hexose 16
hexose 16
adenylate 16
hexose 16
nitrate 16
hexose 16
tryptophan 15
Hearts 15
isoleucine 15
tryptophan 15
tryptophan 15
Hearts 15
galactose 15
tryptophan 15
aspartic acid 14
TNF 14
ubiquinone 14
aspartic acid 14
coenzyme Q10 14
aspartic acid 14
isoleucine 14
PEG 13
NH2 13
glutamic acid 13
cadmium 13
Glutamate 13
cyanide 12
aldehyde 12
zinc 12
phosphorus 12
malic acid 11
valine 11
ACS 11
malic acid 11
PDH 11
GTP 11
ACS 11
guanidine 11
malic acid 11
Pyruvate kinase 10
ubiquinol 10
Resveratrol 10
pyridine 10
Carnitine 10
aldosterone 10
palmitic acid 10
GSSG 10
Triton X-100 9
alloxan 9
GABA 9
methanol 9
Malate 9
Coenzyme Q10 9
Carbon 9
GABA 9
selenium 8
asparagine 8
cAMP 8
CoQ 8
N-acetylcysteine 8
bromide 8
acetoacetyl-CoA 8
GDP 8
carbonate 8
ornithine 7
FFA 7
CAT 7
CAT 7
ornithine 7
manganese 7
more...