Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.3.3.1 (
citrate synthase
)
4,488
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Korean water deer (
Hydropotes inermis argyropus
) are widespread in the Republic of Korea (ROK). Mostly, Korean water deer are essential hosts for maintaining ticks and tick-borne diseases (TBDs). Here, we investigated the prevalence of tick-borne pathogens (TBPs) among rescued Korean water deer.
Anaplasma phagocytophilum
(21.4%, 6/28),
Anaplasma capra
(14.3%, 4/28),
Babesia capreoli
(3.6%, 1/28), and
Coxiella burnetii
(3.6%, 1/28) were detected, but
Borrelia burgdorferi
,
Ehrlichia
,
Rickettsia
, and
Theileria
infections were not found.
A. phagocytophilum
was the most commonly detected pathogen, and co-infection with
A
.
capra
and
B
.
capreoli
was also noted in one Korean water deer. To our knowledge, this is the first article of
B
.
capreoli
infection in Korean water deer in the ROK. The infecting isolate of
A. phagocytophilum
was genetically characterized by 16S ribosomal RNA (rRNA) gene and
ankyrin-related
protein (
ankA
) gene. Although the 16S rRNA gene alone may not be informative enough to delineate distinct host species,
ankA
-based phylogeny revealed a high identity of Korean water deer sequences with those of the causative agent of human granulocytic anaplasmosis.
A. capra
was detected by using
citrate synthase
gene (
gltA
), heat-shock protein (
groEL
), and major surface protein 4 (
msp4
) genes. Phylogenetic tree based on these gene markers revealed that there were at least two distinct variants within
A. capra
circulating in the ROK. One variant originated from different hosts including humans, ticks, goats, and sheep, whereas the other variant was reported recently in Korean water deer in the ROK. Consequently, these sequences were identified to belong to a zoonotic species. Sequencing analysis of the 18S rRNA gene revealed that our isolate belonged to
B. capreoli
and was distinct from
Babesia divergens
and
Babesia venatorum
. Moreover, our isolate showed 92.2% homology with
B. capreoli
sequences, indicating that these differences may be attributed to the different tick species that transmit
B. capreoli
or to different host species. Genotyping and phylogenetic analysis of
C. burnetii
based on 16S rRNA and IS1111 genes revealed that our isolate was grouped with several strains of
C. burnetii
and was genetically distant from
Coxiella
-like bacteria isolates. The present results highlight that Korean water deer act as potential reservoir hosts for zoonotic TBPs, and thus play an important role in the transmission of TBDs in humans, animals, and livestock.
...
PMID:Identification of Zoonotic Tick-Borne Pathogens from Korean Water Deer (
Hydropotes inermis argyropus
). 3259 38
