Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.3.3.1 (citrate synthase)
 4,488 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of this study was to determine whether endurance training alters the cardiovascular response to static contractions of the trained, but not untrained, musculature. Six healthy, untrained males (aged 23-36 years) underwent 10-12 weeks of intensive training involving both cycling and running. Peak VO2 on the bicycle ergometer, VO2max during graded treadmill running and concentrations of citrate synthase (CS) and malate dehydrogenase (MDH) in the vastus lateralis muscle were measured before and after training. Subjects performed static leg extension and forearm extension at 30% of maximal voluntary contraction until exhaustion before and after training. Heart rate (HR), systolic (SBP) and diastolic (DBP) blood pressure were measured at rest, and in addition to perceived exertion (PE), every 30 s during contraction. Endurance training elicited significant increases in peak VO2 (36%), VO2max (32%), CS (25%) and MDH (42%) (all P less than 0.05). HR at rest was significantly lower (P less than 0.05) after training, while SBP and DBP were unchanged. HR, SBP, DBP and PE increased throughout both types of static contractions. However, the magnitude of the increases were unaffected by training. In contrast to recent findings, these results suggest that the increases in heart rate and blood pressure in response to static contraction are not altered after endurance training in either the trained or the untrained muscle groups.
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PMID:Failure of endurance training to alter the cardiovascular response to static contraction. 668 7

The aim of this study was to determine if there is a relationship among skeletal muscle fiber composition, capillarization, blood pressure (BP) and/or the components of the metabolic syndrome. Two groups were compared: 8 recently diagnosed, untreated, hypertensive men (BP > or = 140/90) and 7 normotensive men as controls. Muscle biopsies were taken from the vastus lateralis part of quadriceps femoris muscle in order to assess: fiber type proportion, capillarization, hexokinase, citrate synthase, beta-hydroxyacyl CoA dehydrogenase activities; lipoprotein lipase mass and activity, free fatty acids and triglycerides. Serum levels of insulin, glucose, cholesterol, uric acid and triglycerides were also assayed. Hypertensive patients had higher insulin levels and insulin resistance [homeostasis model assessment (HOMA)], a decreased hexokinase activity and an increase of muscle lipoprotein lipase mass as compared to controls. Interestingly, correlations among values differ in each group. The percentage of type IIB fibers was related to diastolic BP (blood pressure) in control and to mean BP in hypertensive subjects. Serum cholesterol and glucose were inversely related to the percentage of type I fibers in the control subjects. Negative correlations between capillarization and glucose, cholesterol and uric acid levels were found in control subjects. In all subjects, a strong correlation was found between SBP (systolic BP) and DBP (diastolic BP), and insulin resistance (IR) and uric acid levels. Muscle fiber type proportion and capillarization were related to blood pressure and components of the metabolic syndrome.
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PMID:Muscle fiber composition and capillarization in relation to metabolic alterations in hypertensive men. 1132 89