Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.3.3.1 (citrate synthase)
 4,488 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect on skeletal muscle of acute viral and mycoplasma infections in thirteen men of ages ranging between 20-42 years has been studied. Comparisons are made with eight healthy men in the age group 22-29 years who were confined to bed for periods of time of lengths similar to the confinement to bed of the patients. Muscle samples were taken from the thigh. Glyceraldehyde-3-phosphate (triosephosphate) dehydrogenase (TPD), lactate dehydrogenase (LDH), citrate synthetase (CS) and cytochrome oxidase (cytox) activities were measured and the ultrastructure of the muscle specimens was studied by electron microscopy. Immobilization of the healthy persons induced decreased activities of CS, but those of TPD, LDH and cytox remained unaffected. Return to normal life restored the CS activity. The activities of the four enzymes were lower in the patients than in the healthy subjects after immobilization. During normal life, the activities slowly rose to levels as those seen in the healthy subjects. In connection with the acute disease, focal ultrastructural changes within the muscle were found. The changes were similar to those reported to occur in other, more specific muscle diseases.
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PMID:Effects of viral and mycoplasma infections on ultrastructure and enzyme activities in human skeletal muscle. 17 68

8 male patients (age 65-82 years) suffering from bacterial pneumonia or erysipelas were subjected to skeletal muscle biopsies. Significantly lower activities of lactate dehydrogenase (LDH) and glyceraldehyde-3-phosphate dehydrogenase (TPD) of skeletal muscle were recorded in the acute phase of the illness as compared to after the end of the convalescent phase. For citrate synthetase (CS) a similar although non-significant tendency was observed, while cytochrome c oxidase (CYTOX) was not altered by infection. Similar results have been reported in young patients with viral and mycoplasma infections. In the old patients the activity of LDH was approximately half of that found in the young patients (and in young controls confined to bed) on all occasions of measurement.
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PMID:Human skeletal muscle in bacterial infection: enzyme activities and their relationship to age. 19 74

The quantitative effects of acute viral and mycoplasma infections on subcellular elements of skeletal muscle have been investigated in seven hospitalized patients, aged 20-42 years, and the findings are correlated to the activities of glyceraldehyde-3-phosphate (triosephosphate) dehydrogenase (TPD), lactate dehydrogenase (LDH), citrate synthetase (CS), and cytochrome c oxidase (cytox). Comparisons are made with five healthy men, aged 22-29 years, who were confined to bed for 7 days, being the mean period of confinement to bed in the patients. The muscle samples were taken from the thigh. In both patients and controls a decrease of the volume fraction of the myofibrillar compartment was observed in the acute phase of the illness when compared to 4 months afterwards. It was inversely related to the volume fraction of the sarcoplasmic space. The volume fraction of unspecified vacuols was increased in the acute phase and was greater than that of the control subjects confined to bed. The fraction of sarcoplasmic space and that of vacuols correlated negatively to the activity of CS. The activity of cytox correlated to the volume fraction of mitochondria. No correlations were found for TPD or LDH.
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PMID:Human skeletal muscle in viral and mycoplasma infections: ultrastructural morphometry and its correlations to enzyme activities. 2007 15