Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.3.3.1 (citrate synthase)
 4,488 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of chronic administration for 6 weeks of an anabolic steroid, nandrolone phenylpropionate (Durabolin), was studied in three predominantly glycolytic muscles, and three oxidative muscles of sedentary female rats. Mean blood pressure and resting heart rate (HR) were lower in the anabolic-treated group, while the increase in HR during stimulation of EDL was reduced. No change was noted in the aerobic capacity of ventricular myocardium, although there was an increase in skeletal muscles due to a combination of increased capillary supply and/or TCA cycle enzyme activity. Capillary:fibre ratio (C:F) increased around 10% in glycolytic muscle with little effect on resting blood flow (BF). In EDL C:F was 1.1 +/- 0.02 vs. 1.2 +/- 0.01 and BF was 7.0 +/- 1.45 vs. 6.2 +/- 1.82 ml min-1 100 g-1 for control and Durabolin treated animals, respectively (means +/- SEM, n = 7). No increase in citrate synthase (CS) activity was evident. In soleus, where C:F was not significantly different between groups, CS activity increased from 3.9 +/- 0.34 to 5.9 +/- 0.40 microM g-1 min-1 (means +/- SEM, n = 7). Glycolytic capacity, indicated by pyruvate kinase activity, increased only in diaphragm. These data demonstrate that total oxidative metabolism of striated muscle does not necessarily increase with greater proportion of FOG fibres, nor is it always correlated with capillary supply. The positive myotrophic effect of Durabolin represents the sum of modest changes at different levels of organisation.
 ...
PMID:Effects of an anabolic hormone on aerobic capacity of rat striated muscle. 343 43

To test the effect of nandrolone on their recovery, six adult half-bred riding horses performed a competition exercise test (CET) and a standardized exercise test (SET) on consecutive days before and after a 2-week treatment with the anabolic steroid nandrolone laurate. Blood samples were collected during and between these tests for the determination of red cell volume and concentrations of blood lactate, plasma glucose, non-esterified fatty acids, glycerol, triglycrides, erythropoietin, cortisol, insulin, and glucagon. Muscle biopsy specimens were taken immediately after the CET and before the SET for analysis of glycogen content, citrate synthase, and 3-hydroxyacyl CoA dehvdrogenase activity. Nandrolone administration increased the rate of muscle glycogen repletion after exercise, an increase that may be explained by increased glucose output by the liver, higher plasma insulin concentration, and increased insulin-independent glucose transport, but not by better availability of lipid fuels during recovery.
 ...
PMID:Effects of nandrolone treatment on recovery in horses after strenuous physical exercise. 1155 92