Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.3.3.1 (citrate synthase)
 4,488 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. Activities of a glycolytic enzyme--lactate dehydrogenase, LDH, and two oxidative enzymes--citrate synthase (CS), a marker for TCA cycle entry, and 3-hydroxyacyl-CoA dehydrogenase (HAD), which indicates the capacity for beta-oxidation of endogenous lipids, were measured in fast (tibialis anterior, TA, and extensor digitorum longus, EDL) and slow (soleus, SOL) muscles of Sprague-Dawley rats with intact and limited blood supply, and following treatment with the xanthine derivative torbafylline (Hoechst, Werk Albert, Wiesbaden). 2. Limitation of blood supply by unilateral ligation of the common iliac artery increased activity of LDH in fast muscles, and activity of CS and HAD in soleus. 3. Torbafylline treatment caused an increased LDH activity in intact fast muscles and decreased it in soleus, although the relative capacity for anaerobic and aerobic metabolism (indicated by the ratio of LDH and CS activities) remained unchanged in all cases. 4. Whilst having little effect on oxidative enzyme activity of fast muscles, torbafylline decreased the activity of CS but increased activity of HAD in soleus, suggesting a greater reliance on lipid metabolism. 5. The effect of arterial ligation on enzyme activity was ameliorated by treatment with torbafylline, possibly due to its effect on the microcirculation.
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PMID:The effect of torbafylline on enzyme activities in fast and slow muscles with limited blood supply. 167 66

Reeves, Henry C. (Albert Einstein Medical Center, Philadelphia, Pa.) and Samuel J. Ajl. Function of malate synthetase and isocitritase in the growth of bacteria on two-carbon compounds. J. Bacteriol. 83:597-601. 1962.-Escherichia coli, grown in a glucose-citrate medium under anaerobic conditions, is devoid of the enzymes malate synthetase and isocitritase. It has been demonstrated that the adaptation of such cells to aerobic growth in a medium containing acetate as the sole carbon source involves at least two separate events. The first appears to be an adaptation which permits the oxidative dissimilation of acetate and involves primarily the synthesis of condensing enzyme. The second, which also precedes all division, is the synthesis of isocitritase and malate synthetase. Finally, a definite correlation has been found to exist between the synthesis of isocitritase and malate synthetase and the lag period prior to cell proliferation.
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PMID:Function of malate synthetase and isocitritase in the growth of bacteria on two-carbon compounds. 1449 Oct 17