Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.3.3.1 (
citrate synthase
)
4,488
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The human gene for histidase (histidine ammonia-lyase; HAL), the enzyme deficient in
histidinemia
, was assigned to human chromosome 12 by Southern blot analysis of human X mouse somatic cell hybrid DNA. The gene was sublocalized to region 12q22----q24.1 by in situ hybridization, using a human histidase cDNA. The homologous locus in the mouse (Hal) was mapped to region 10C2----D1 by in situ hybridization, using a cell line from a mouse homozygous for a 1.10 Robertsonian translocation. These assignments extend the conserved syntenic region between human chromosome 12 and mouse chromosome 10 that includes the genes for phenylalanine hydroxylase, gamma interferon, peptidase, and
citrate synthase
. The localization of histidase to mouse chromosome 10 suggests that the histidase regulatory locus (Hsd) and the
histidinemia
mutation (his), which are both known to be on chromosome 10, may be alleles of the histidase structural gene locus.
...
PMID:Localization of histidase to human chromosome region 12q22----q24.1 and mouse chromosome region 10C2----D1. 205 14
