Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.3.1.21 (CPT)
 4,580 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The mechanisms and structure-activity by which dissolved dietary sugars influence drug release from hydroxypropyl methylcellulose (Methocel K4M) matrices were investigated. Drug release was retarded at lower sugar concentrations, but above a critical solute concentration (S(CRIT)), there was marked acceleration of release. Studies of early gel layer formation suggested this resulted from sugar-induced suppression of HPMC particle swelling and coalescence, leading to gel structures with poorer diffusion-barrier properties and reduced resistance to physical erosion. Sucrose, lactose, D-glucose, D-galactose and D-fructose all exhibited this pattern but S(CRIT) values varied widely between sugars (0.5 M lactose, 1.15 M D-fructose). A polynomial relationship (r(2)=0.994) existed between S(CRIT) and the ability of the sugar to depress the polymer sol-gel transition temperature (Delta CPT). Structure activity relationships across a wide range of sugars suggested Delta CPT was related to molar hydroxyl number, the orientation of the C(4) hydroxyl and the beta 1-->4 linkage, all factors which influence sugar compatibility with water structure. The study demonstrates how sugars in high concentration can directly influence the performance of the gel diffusion barrier and matrix drug release characteristics. There is therefore potential for influencing drug release kinetics when high concentrations of sugars are co-administered in the fed state or when they are present in HPMC ER formulations.
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PMID:The extended release properties of HPMC matrices in the presence of dietary sugars. 1946 31