Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.3.1.21 (
CPT
)
4,580
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We characterized the promoters of target genes of the
signal transducer and activator of transcription 3
, STAT3 (
carnitine palmitoyltransferase I
,
CPT
Iα1b
, acetyl-CoA carboxylase alpha,
ACCα
; fatty acid synthase,
FAS
; and peroxisome proliferator-activated receptor gamma,
PPARγ
) in a teleost
Pelteobagrus fulvidraco
. Binding sites of STAT3 were predicted on these promoters, indicating that STAT3 probably mediated their transcriptional activities. Leptin had no effect on the activity of
ACCα
and
PPARγ
promoters, but increased
CPT
Iα1b
promoter activity and decreased
FAS
promoter activity. The −979/−997 STAT3 binding site of
CPT
Iα1b
and the −794/−812 STAT3 binding site of
FAS
were functional binding loci responsible for leptin-induced transcriptional activation. The study provided direct evidence that STAT3 regulated the expression of
CPT
Iα1b
and
FAS
at the transcription level, and determined the STAT3 response element on promoters of
CPT
Iα1b
and
FAS
under leptin signal.
...
PMID:Functional Analysis of Promoters of Genes in Lipid Metabolism and Their Transcriptional Response to STAT3 under Leptin Signals. 2997 Aug 3
