Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.3.1.21 (CPT)
 4,580 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The growth of the renal parenchyma was examined in children with duplicated outflow systems, vesicoureteral reflux (VUR), urinary tract infection (UTI) and no sign of obstruction. Ten patients with reflux occurring only in the caudal system (group A) and 4 patients with reflux both to the caudal and the apical system (group B) were studied shortly after their first UTI (study 1) and then 1.5 to 9 years later (study 2). The frequency of UTI was relatively high during the follow-up period. At urography, renal length and renal area were normal in group A in studies 1 and 2. Parenchymal thickness of the apical pole (APT/L) did not differ from normal values in any of the studies. Parenchymal thickness of the caudal pole (CPT/L) was significantly smaller than normal in both studies. There was also a significant decrease in CPT/L between study 1 and 2. UTI during the first year of life was associated with a greater reduction in CPT/L. The determination of renal length and renal area in children with a duplicated ureter, VUR and UTI, does not identify subjects at risk of developing renal growth retardation while serial determinations of parenchymal thickness appear to be an appropriate method.
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PMID:Influence of vesicoureteral reflux and urinary tract infection on renal growth in children with upper urinary tract duplication. 277 2

In a retrospective study, 57 patients were examined following an intra-articular cruciate ligament reconstruction. The patients were divided into four groups according to the type of repair and the lapse of time between injury and operation. Twenty-five patients had undergone reconstruction with a semitendinosus tendon after acute instability (AST) and six, after chronic instability (CST). Eleven patients had received an acute reconstruction using the middle third of the patellar tendon (APT), as had 15 with chronic instability (CPT). The mean follow-up time was 48 months for the AST group, 60 months for the CST, 33 months for the APT, and 36 months for the CPT. In order to compare the groups, we used the Lysholm and OAK scores and the IKDC evaluation system. The only statistically significant difference found involved the IKDC evaluation system between the AST and CST groups. No significant decrease in activity level was noted in any of the groups. With the exception of the CST group, the preoperative Lachman test disappeared significantly at follow-up in all groups. The side-to-side difference of anterior tibial displacement measured with the KT 2000 at 25 degrees knee flexion and a load of 89 newtons was 1.32 mm for the APT group, 2.44 mm for the AST group, 2.47 mm for the CPT group, and 3.33 mm for the CST group. This side-to-side difference was not significant in the APT group. In the CPT group, arthrofibrosis was found in 27% of the patients, which led to reoperation. Reconstruction of the anterior cruciate ligament using the semitendinosus is no longer indicated for chronic instability. ACL-plasty with the middle third of the patellar tendon restored practically normal stability in acute ACL insufficiency.
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PMID:Retrospective comparison of four intra-articular anterior cruciate ligament reconstructions using three evaluation systems. 769 44

Cystic fibrosis (CF) patients with Burkholderia cepacia complex (Bcc) pulmonary infections have high morbidity and mortality. The aim of this study was to compare different methods for identification of Bcc species isolated from paediatric CF patients. Oropharyngeal swabs from children with CF were used to obtain isolates of Bcc samples to evaluate six different tests for strain identification. Conventional (CPT) and automatised (APT) phenotypic tests, polymerase chain reaction (PCR)-recA, restriction fragment length polymorphism-recA, recA sequencing, and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) were applied. Bacterial isolates were also tested for antimicrobial susceptibility. PCR-recA analysis showed that 36 out of the 54 isolates were Bcc. Kappa index data indicated almost perfect agreement between CPT and APT, CPT and PCR-recA, and APT and PCR-recA to identify Bcc, and MALDI-TOF and recA sequencing to identify Bcc species. The recA sequencing data and the MALDI-TOF data agreed in 97.2% of the isolates. Based on recA sequencing, the most common species identified were Burkholderia cenocepacia IIIA (33.4%),Burkholderia vietnamiensis (30.6%), B. cenocepaciaIIIB (27.8%), Burkholderia multivorans (5.5%), and B. cepacia (2.7%). MALDI-TOF proved to be a useful tool for identification of Bcc species obtained from CF patients, although it was not able to identify B. cenocepacia subtypes.
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PMID:Polyphasic characterisation of Burkholderia cepaciacomplex species isolated from children with cystic fibrosis. 2681 42