Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.3.1.21 (CPT)
 4,580 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of the investigation was to throw light on the question whether drugs other than antibiotics and chemotherapeutic agents exert an antimicrobial effect. In order to elucidate this, the antimicrobial effect of selected psychotherapeutic drugs and their stereo-isomeric analogues was studied. The development of psychotherapeutic drugs from aniline dyes has been reviewed against the background of its history considered as a scientific idea. It is demonstrated that psychotherapeutic drugs have an antimicrobial effect. Psychotherapeutic drugs show antimicrobial activity at high concentrations. Stereo-isomeric analogues of known psychotherapeutic drugs also have an antimicrobial effect. The selectivity of the various stereo-isomeric compounds depends on which microorganism and which chemical compound is investigated. Synergism is found between psychotherapeutic drugs (CPZ) and penicillin in vitro, and between a non-neuroleptic stereo-isomeric compound trans-CPT and penicillin in vivo, using infected mice as material. The antibacterial activity of psychotherapeutic drugs is independent of the antihistaminic, antihypersecretory, neuroleptic and antidepressant effect of these drugs. The examples chosen of investigations of the antimicrobial effect of psychotherapeutic drugs in vitro and in vivo lead to the conclusion and to the perspectives in the present study. Namely, the need for a general theory of the interplay between host organism, microorganisms and drugs. This proposition is based on a concern to argue against the view that the prokaryotic effect of eukaryote-directed drugs is without major significance, either for scientific research or for clinical treatment.
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PMID:The antimicrobial activity of psychotherapeutic drugs and stereo-isomeric analogues. 218 4

3-Chloro-p-toluidine hydrochloride (CPT-HCl) is an aniline derivative used in the manufacture of the dye palatine fast yellow; it is also registered as a selective, low-volume-use (< 45 kg/yr) avicide. Three in vitro mutagenicity tests of CPT-HCl were performed according to methods recommended by the U.S. Environmental Protection Agency (EPA): the Ames/Salmonella assay, the Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl-transferase (CHO/HPRT) mammalian cell forward gene mutation assay, and the CHO chromosome aberration assay. CPT-HCl did not display mutagenic activity using the Ames/Salmonella or CHO/HPRT assays. However, CPT-HCl induced statistically significant, concentration-dependent, metabolically activated increases in the proportion of aberrant cells and aberrations/cell in cultured CHO cells. Results are suggestive of minimal mutagenicity effects associated with exposure to anilines and their derivatives.
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PMID:3-Chloro-p-toluidine hydrochloride: in vitro mutagenicity studies for human health hazards determinations. 914 Apr 64