Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.3.1.21 (
CPT
)
4,580
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
An exopolysaccharides/calcipotriol (
EPS
/
CPT
) emulsion was prepared using bacterial
EPS
as emulsifier, sunflower oil as an oil phase and
CPT
as the loaded drug, and the effect of this emulsion on psoriasis vulgaris treatment was evaluated. An
EPS
composed of mannose (70.56%) and glucose (29.44%) was obtained from the marine mangrove bacteria
Bacillus amyloliquefaciens
ZWJ (Zhu Wenjing) strain. The
EPS
has significant emulsifying activity at the concentration of 1.5%. The prepared
EPS
/
CPT
emulsion has small and stable particle size, with a drug content of 0.00492%, and good spreading properties. The in vitro drug release results revealed that the emulsion showed a certain sustained release effect. In vitro and in vivo animal experiments show that the
EPS
/
CPT
emulsion can effectively treat psoriasis vulgaris by increasing the accumulation of
CPT
in psoriatic skin lesions and reducing the levels of inflammatory cells and inflammatory factors (TNF and IL6). Additionally, it has a certain effect on reducing the side effects associated with
CPT
. This study lays a foundation for the research of
EPS
in the topical application of medical materials and treatment of psoriasis.
...
PMID:Preparation of Calcipotriol Emulsion Using Bacterial Exopolysaccharides as Emulsifier for Percutaneous Treatment of Psoriasis Vulgaris. 3186 34
