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Query: EC:2.3.1.21 (CPT)
 4,580 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

CPT: Pharmacometrics & Systems Pharmacology (CPT:PSP) is an online-only, open access (OA) journal, which means that anyone, anywhere in the world, can access, download, print out, and read articles published here immediately upon publication on the journal's website at Nature and simultaneous deposit in the public-access repository, PubMed Central. Using a Creative Commons license for authors, CPT:PSP permits authors to retain copyright in their articles and permits readers to download and reuse (with attribution) tables, data, and other elements of a paper. This Perspective provides an introduction to authors and readers of this new ASCPT journal about this approach to publishing.CPT: Pharmacometrics & Systems Pharmacology (2012) 1, e7; doi:10.1038/psp.2012.7; advance online publication 26 September 2012.
CPT Pharmacometrics Syst Pharmacol 2012 Sep 26
PMID:Open access: a new model for publishing in the pharmacological sciences. 2383 87

Welcome to the first issue of CPT: Pharmacometrics and Systems Pharmacology (CPT:PSP), a new journal from the American Society for Clinical Pharmacology and Therapeutics. CPT:PSP is a cross-disciplinary journal devoted to publishing advances in quantitative, model-based approaches as applied in pharmacology, (patho)physiology, and disease to aid the discovery, development, and utilization of human therapeutics. The emphasis of CPT:PSP will be on the application of modeling and simulation and the impact of Pharmacometrics and Systems Pharmacology on the discovery and development of innovative therapies.CPT: Pharmacometrics & Systems Pharmacology (2012) 1, e8; doi:10.1038/psp.2012.8; advance online publication 26 September 2012.
CPT Pharmacometrics Syst Pharmacol 2012 Sep 26
PMID:CPT: Pharmacometrics and Systems Pharmacology. 2383 88

In addition to methodological Tutorials,(1) CPT:PSP has recently started to publish software Tutorials.(2,3) Our readership and authors may be wondering what kind of format or product is expected, and the review of submissions we have already received prompted several discussions within the PSP Editorial Team. This editorial reflects on these discussions and summarizes their salient points. It aims at providing some details about the current vision of CPT:PSP for software tutorial articles. In addition, it brings some clarity on the topic of what role commercial software tutorials can have in CPT:PSP and how CPT:PSP tutorials differ from publications which describe the software itself, as those which can be found in other computer science journals. Finally, the discussion includes reproducibility considerations and the general use of commercial and noncommercial software in CPT:PSP publications. We hope our thoughts, and especially a stated requirement to publish user input to the software to aid in reproducibility, will help in guiding our authors and will stimulate healthy debate among our readers about the evolving nature of our science, how it can be facilitated using software and associated databases as a conduit, and what role this journal can play in fostering both the best modeling and simulation practices and the best scientific approaches to computational modeling, to bring the advantages of modeling and simulation to all regular practitioners, and not to just a (self) selected few.
CPT Pharmacometrics Syst Pharmacol 2013 Dec 18
PMID:Pharmacometrics and Systems Pharmacology Software Tutorials and Use: Comments and Guidelines for PSP Contributions. 2435 22

It is no coincidence that the reports of two meetings, one organized by the US Food and Drug Administration (FDA), in March 2014, and the other by the UK Medicines and Healthcare Products Regulatory (MHRA), in collaboration with ABPI (the Association of British Pharmaceutical Industry), in June 2014, have been published in tandem in CPT-PSP.12 Both reports deal with the same topic, namely, the impact of physiologically based pharmacokinetics (PBPK) in clinical drug development and the best practices for such applications. This reflects the transition of PBPK from academic curiosity to industrial norm, manifested by the regulatory agencies encouraging its use and receiving an increasing number of submissions containing PBPK models. The goal of both meetings was to help determine the need and facilitate the development of regulatory guidances on this subject within the conceptual framework of model informed drug development and regulatory decision-making. A further reflection of this intent is the publication by the European Medicines Agency of a Concept Paper on PBPK.3 One is reminded of a similar train of events surrounding the introduction of population PK/PD and nonlinear mixed effects modeling in the early-late 1990s, again with encouragement and receptivity of regulatory agencies leading to FDA guidance on the topic.4 Indeed, the intention of PBPK modeling and simulation is to complement other approaches, such as compartmental modeling, or, in some cases, replace them with a more mechanistic approach. PBPK models represent an important class of models that characterize absorption, distribution, metabolism, excretion (ADME) processes and their underlying biological and physiological drivers. An increased understanding of these drivers and their unique interactions with drug substance and formulation factors provides critical insights into how drugs will behave in healthy volunteers and patients with disease.
CPT Pharmacometrics Syst Pharmacol 2015 Jun
PMID:Physiologically Based Pharmacokinetics Is Impacting Drug Development and Regulatory Decision Making. 2622 58