Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.3.1.177 (BIS)
 957 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Non-fatal self-injurious behavior such as cutting oneself is often performed without suicidal intent to cope with emotional distress, although it is well-known to have a close association with future suicidal behavior. However, it is unclear what kinds of clinical features are presented by such self-injuring patients with a higher suicidal tendency. In the present study, we conducted a three-year follow-up study of female self-injuring patients to examine the risk factors of "near-fatal" deliberate self-harm behavior (DSH). The subjects were 81 female outpatients who had cut themselves at least once, and who had consulted a psychiatric clinic from June 2004 to July 2004. Initial assessments included traumatic life events, clinical features of self-cutting, histories of self-poisoning, alcohol abuse (Alcohol Use Disorders Identification Test: AUDIT), impulsivity (Barratt Impulsiveness Scale, 11th version: BIS-11), symptoms of bulimia nervosa (Bulimia Investigatory Test, Edinburgh: BITE), dissociation (Adolescent Dissociative Experience Scale: ADES), Global Assessment of Functioning (GAF) score, and axis I diagnosis of DSM-IV (Diagnostic and Statistical Manual, 4th version). After three years, we investigated whether the subjects had committed fatal DSH during the follow-up term. We obtained information on fatal DSH from 67 subjects during the follow-up term. Fifteen of the 67 (22.4%) had committed near-fatal DSH at least once, and one subject committed suicide by fatal DSH. Monovariate analysis revealed that in the initial assessment, the subjects with near-fatal DSH episodes more frequently reported a history of victimization by rape in adulthood and a history of OTC (over-the-counter) drug self-poisoning, and had higher scores on the BITE and AUDIT than those without near-fatal DSH episodes. Further, multivariate analysis demonstrated that only the BITE score was a significant factor in predicting future near-fatal DSH. In conclusion, symptoms of bulimia nervosa may have important clinical implications. The BITE may be a useful tool to assess future suicidal behavior in female self-cutting patients.
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PMID:[Risk factors of near-fatal deliberate self-harm behavior in self-cutting patients: a three-year follow-up study at a psychiatric clinic]. 1871 58

The contribution of an addictive process to anorexia nervosa (AN) is an area of growing interest. Yet, little is known about how the food addiction concept (FA) may be of interest in understanding AN. This study investigates prevalence of FA diagnostic and its association with markers of severity in individuals with AN. We conducted a retrospective study in a sample of 73 patients with AN. We assessed FA with the Yale Food Addiction Scale 2.0, depressive and anxiety disorders, impulsivity (Beck Depression Inventory, STAI, BIS-11) and eating behavior (BITE, EDE-Q). Prevalence of FA in our sample was 47%. FA was significantly associated and positively correlated with the binge-eating/purging subtype of AN, higher levels of depression, anxiety and greater eating psychopathology. FA was not associated with level of impulsivity nor leptin and IGF-1 blood levels. The relationship between FA severity and AN severity was mediated by the severity of binge eating behaviors. Our results suggest that the presence of FA may represent a more severe variant of AN. Longitudinal studies are needed to better understand the etiologic process between FA and AN.
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PMID:FOOD ADDICTION AS A PROXY FOR ANOREXIA NERVOSA SEVERITY: NEW DATA BASED ON THE YALE FOOD ADDICTION SCALE 2.0. 3300 84