Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.3.1.177 (BIS)
 957 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A patient presented with recurrent facial dermatitis associated with dental work. Dermatology referral identified the cause as allergic contact dermatitis to the epoxy acrylate BIS-GMA. Occupationally-induced allergic contact dermatitis to epoxy resin was also demonstrated. A structurally distinct aliphatic acrylate was successfully substituted. Contact sensitivity to BIS-GMA is reviewed and the potential for epoxy sensitive patients to cross-react to BIS-GMA is discussed.
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PMID:Allergic contact dermatitis to bisphenol-A-glycidyldimethacrylate (BIS-GMA) dental resin associated with sensitivity to epoxy resin. 937 44

One hundred and eighty four strains of methicillin resistant Staphylococcus aureus (MRSA) isolated in pyosurgical and burn departments of Moscow, Minsk, Omsk, Tbilisi, Vologda, Smolensk and Dushanbe were differentiated with using phages of the International Set (BIS), two collections of experimental phages and two-probe fingerprinting. More than 50 per cent of the isolates could not be typed by the BIS phages. The Experimental Collection of the N.F. Gamaleya Research Institute of Epidemiology and Microbiology (Moscow) was more useful in the differentiation in comparison to the Experimental Collection of the London Health Centre. A new approach applied by us to the establishment of our collection i.e. screening of cultures with a definite specificity of the system of the restriction-modification (by a modified phage 85) followed by their differentiation with respect to the specificity of the prophages (by the induced phages with the respective modification specificity) provided reliable and reproducible results. Our collection made it possible to classify the phage type 85 strains which as was confirmed by the fingerprinting data belonged to 3 different genotype variants. The fingerprinting had no advantages over the typing by the phages of the more extended phage set and was recommended for differentiation of the strains (14 per cent) not sensitive to the phages used. A step-by-step scheme for typing MRSA easy for use in clinical and epidemiological laboratories is described.
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PMID:[A system of step-by-step differentiation of methicillin-resistant Staphylococcus aureus]. 941 15

The bispecific monoclonal antibody (bsAb) BIS-1 combines a monoclonal-antibody(mAb)-defined specificity for the CD3 complex, as present on all T lymphocytes, with a mAb-defined specificity for the pancarcinoma/epithelium associated glycoprotein EGP-2. In vitro studies indicate that BIS-1 can direct T lymphocytes to kill EGP-2-positive tumour target cells. T cell pre-activation is necessary for this activity and can be obtained either via incubation of isolated peripheral blood mononuclear cells with CD3 mAb, followed by short culturing in recombinant interleukin-2-containing medium, or via costimulation with CD5- and CD28-based bsAb. Clinical application of BIS-1 was started in a pilot study in which carcinoma patients suffering from malignant ascites or intrapleural effusion were treated. In this study, ex vivo activated autologous lymphocytes were applied locally, i.e. intraperitoneally or intrapleurally, in the presence of BIS-1. Local inflammation and antitumour activity were observed, whereas no or only minor systemic toxicity was seen in these patients. Intravenous administration of BIS-1 F(ab')2 in combination with subcutaneously given recombinant interleukin-2 (i.v. bsAb/rIL-2 treatment) induced transient but considerable toxicity including peripheral vasoconstriction, dyspnoea and fever with a maximal tolerated dose of 5-8 micrograms/kg. High plasma concentrations of the inflammatory cytokines tumor necrosis factor alpha and interferon gamma were observed at this dose. Whereas bsAb-dictated antitumour activity could be demonstrated to be present in blood samples of these patients in an in vitro assay, no clear clinical responses were observed. In a rat model it was found that i.v. bsAb/rIL-2 treatment of EGP-2-positive tumours was effective when a low systemic tumour burden was present, suggesting that systemic bsAb/rIL-2 treatment might be effective in situations of minimal residual disease.
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PMID:Approaches to lung cancer treatment using the CD3 x EGP-2-directed bispecific monoclonal antibody BIS-1. 943 74

Statistics on 10 years of patch testing with 30 (meth)acrylates were compiled. Altogether 275 patients were patch tested and 48 patients (17.5%) had an allergic reaction to at least 1 (meth)acrylate. The (meth)acrylates most often provoking an allergic patch test reaction were 2-hydroxyethyl acrylate (2-HEA; 12.1%), 2-hydroxypropyl methacrylate (2-HPMA; 12.0%) and 2-hydroxyethyl methacrylate (2-HEMA; 11.4%). No allergic reactions were caused by 2-ethylhexyl acrylate (2-EHA), 2,2-bis[4-(methacryloxy)phenyl]propane (BIS-MA), trimethylolpropane triacrylate (TMPTA), oligotriacrylate 480 (OTA 480), N,N-methylenebisacrylamide (MBAA), or ethyl cyanoacrylate (ECA). The frequency of allergic patch test reactions presented cannot be considered as a "ranking" list of the most sensitizing (meth)acrylate compounds. In order to be able to judge the sensitization capacity of various (meth)acrylate compounds in humans, it would be necessary to have detailed information on the exposure history of the patients studied, including the purity of the (meth)acrylate compounds. Currently, this is not possible because (meth)acrylate-containing products regularly contain undeclared (meth)acrylate compounds.
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PMID:10 years of patch testing with the (meth)acrylate series. 945 26

This case was atypical because the patient was conscious and apneic. The usual responses that indicate a patient's distress during terminal weaning would not have been evident in this patient. Introducing noninvasive monitoring of end-tidal CO2 and SpO2 and using BIS allowed the weaning to progress with confidence that the patient was as comfortable as possible. We think we kept our commitment to HD to honor his wishes by using the most humane method we could devise, and to address his family's needs at the same time.
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PMID:Integrating technology with compassionate care: withdrawal of ventilation in a conscious patient with apnea. 965 49

Developed a rating scale to measure body image satisfaction and eating behaviors and disturbances in preadolescent girls and evaluated the psychometric properties of the instrument. The Eating Behaviors and Body Image Test (EBBIT) for preadolescent girls was administered to 291 fourth-, fifth-, and sixth-grade girls to identify the measure's factor structure. Body Image Silhouettes (BIS; Childress, Brewerton, Hodges, & Jarrell, 1993) were also administered, and height and weight measurements were obtained. Although four factors were predicted (maladaptive thoughts about body size, restrictive eating, bingeing, and compensatory behavior for overeating), corresponding to adult criteria for the diagnoses of anorexia and bulimia, factor analysis of the EBBIT suggested only two factors: Body Image Dissatisfaction/Restrictive Eating and Binge Eating Behaviors. Only two compensatory behaviors (exercising to burn off food eaten and skipping meals after overeating) loaded on the scale, and they loaded on the Body Image Dissatisfaction/Restrictive Eating factor. Internal consistency and test-retest reliabilities were adequate to good, and initial validity of the scale was established by using scores on the Body Image Silhouettes, body mass index ratios, age, and race as predictors of EBBIT scores.
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PMID:Underlying dimensions and psychometric properties of the Eating Behaviors and Body Image Test for preadolescent girls. 956 44

Environmental cum medical study was conducted in asbestos cement factory. The environment was evaluated for asbestos fiber by the methods recommended by BIS. Total 355 exposed and 312 suitably matched control workers were investigated by spirometer, Wright's peak flow meter and full sized postero-anterior chest radiograph. The levels of asbestos fiber were 2 to 3 times higher than TLV i.e. 2 f/ml in pipe cutting dept., crude fiber grinding inlet count was more than the ACGIH recommended limit i.e. 5 mpccf of air in pipe cutting dept. and silica mill. In the rest of the department, fiber level as well as dust particle count were below prescribed limit. The comparison of mean values of PFT parameters of workers with 16-20 years exposure history with control one was showing statistically significant decline in mean values of FVC only suggesting restrictive type of PFT impairment in this group of workers. But in workers with more than 20 years exposure, the mean values of all the parameters studied were reduced as compared to control one suggesting combined type of PFT impairment. When the mean values of PFT parameters of exposed smokers were compared with exposed non-smokers there was statistically no significant difference. This can be due to marginal contribution of smoking habit in impairment of PFT parameters of exposed smokers. The percentages of workers with parenchymal and pleural changes due to asbestos exposure were nearly two times more in more than 20 years exposure groups as compared to 11-20 years exposure groups. The parenchymal and pleural changes due to asbestos exposure were more common in exposed smokers as compared exposed non-smokers. However the detailed analysis revealed that if smoking contributes to the development of interstitial fibrosis, the contribution is a marginal one in comparison to the effect of asbestos dust exposure.
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PMID:The relation of exposure to asbestos and smoking habit with pulmonary function tests and chest radiograph. 956 22

This study aimed to evaluate the feasibility and reliability of bioelectrical impedance spectroscopy in young children suffering of acute hydrational disorders. Whole body and segmental measurements were carried out in a group of 42 of children aged 4 to 147 months, using a BIS analyzer (Xitron 4000B). This phase of the study involved several hundred of BIS measurement, which showed the feasibility of using this technique in young children. Using the sweep mode and the modeling software provided for the manufacturer of the instrument, the resistance of the extracellular (RECW) and intracellular (RICW) compartment was calculated. Correlation coefficient (r) and technical error of measurement (TEM) were obtained from paired BIS measurements. RECW showed to be highly reproducible (r = 0.99), with a relatively low TEM (from 1 to 3.5%), across all segments. The reliability was markedly lower respect to RICW, which shows the potential application of BIS technique even in critically ill young child populations.
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PMID:Bioelectrical impedance spectroscopy (BIS) in young children with acute and semi-acute hydration disorders: potentials and limitations. 956 56

This in-vitro investigation sought to identify the most effective softening agents for three commercial anterior resin composites (Prisma APH, Brilliant and Blend-a-Lux) from four potential agents (75% ethanol, polyacrylic acid, acetone and acetic acid), selected as having close solubility parameter values to BIS-GMA. The Vickers microhardness test was applied to samples before and following a 180 s application of each agent. In addition, the degree of cavity enlargement following removal of resin composite restorations, aged by thermocycling, was assessed by image analysis. Using the same method the influence of both colour match and the 180 s application of softening agents, in the optimum chemical/material combinations, upon this was determined. Analyses of variance revealed that significant (P < 0-01) reductions in surface microhardness occurred when 75% ethanol was applied to Prisma-APH and acetic acid to Blend-a-Lux. Removal of restorations of all materials resulted in highly significant (P < 0.001) increases in cavity size. Application of either 75% ethanol to Prisma-APH restorations or acetic acid to Blend-a-Lux did not alter this result. Thermocycling only produced a significant (P < 0.01) (McNemar Test) deterioration in shade match of the Prisma APH restorations but analyses of variance, for all materials, revealed that the observed changes in colour match had no significant (P < 0.05) effect upon the degree of cavity size enlargement. It is concluded that the application of softening agents to reduce cavity enlargement is not a viable clinical option.
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PMID:Can chemical softening agents minimize cavity enlargement during removal of failed anterior resin composite restorations? 957 22

Marginal adaptation to cylindrical dentin preparations of five commercially available dental composites--Charisma, Estelite, Herculite, Pertac, and Silux Plus--and seven experimental dental composites containing prepolymerized filler was evaluated by measurement of the wall-to-wall polymerization contraction gaps. The experimental composites were prepared with varying amounts of spherical inorganic filler particles, irregularly shaped prepolymerized filler particles, and a base resin matrix composed of BIS-GMA and TEGDMA. Cylindrical dentin preparations, approximately 3.0 mm in diameter and 1.5 mm deep, were prepared in the exposed approximal dentin surfaces of extracted human molars. These cavity preparations were pretreated with an experimental dentin bonding system consisting of 0.5 mol/L EDTA, 35% glyceryl methacrylate, and Clearfil Photo Bond, then restored with each composite. Complete marginal adaptation was observed in two composites (Silux Plux and Estelite). Wall-to-wall contraction gaps were significantly related to the amount of ashed inorganic component in the composites (0.01 < P < 0.05) and to the spherical inorganic filler content by volume (P < 0.01).
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PMID:Marginal adaptation of dental composites containing prepolymerized filler. 961 Mar 20


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