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Pivot Concepts:
Gene/Protein
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Drug
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Target Concepts:
Gene/Protein
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Query: EC:2.3.1.177 (
BIS
)
957
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Impulsivity is a transdiagnostic feature of a range of externalizing psychiatric disorders. Preclinical work links reduced ventral striatal
dopamine transporter
(
DAT
) availability with heightened impulsivity and novelty seeking. However, there is a lack of human data investigating the relationship between
DAT
availability, particularly in subregions of the striatum, and the personality traits of impulsivity and novelty seeking. Here we collected PET measures of
DAT
availability (BP
ND
) using the tracer
18
F-FE-PE2I in 47 healthy adult subjects and examined relations between BP
ND
in striatum, including its subregions: caudate, putamen, and ventral striatum (VS), and trait impulsivity (Barratt Impulsiveness Scale:
BIS
-11) and novelty seeking (Tridimensional Personality Questionnaire: TPQ-NS), controlling for age and sex.
DAT
BP
ND
in each striatal subregion showed nominal negative associations with total
BIS
-11 but not TPQ-NS. At the subscale level, VS
DAT
BP
ND
was significantly associated with
BIS
-11 motor impulsivity (e.g., taking actions without thinking) after correction for multiple comparisons. VS
DAT
BP
ND
explained 13.2% of the variance in motor impulsivity. Our data demonstrate that
DAT
availability in VS is negatively related to impulsivity and suggest a particular influence of
DAT
regulation of dopamine signaling in VS on acting without deliberation (
BIS
motor impulsivity). While needing replication, these data converge with models of ventral striatal functions that emphasize its role as a key interface linking motivation to action.
...
PMID:Ventral striatal dopamine transporter availability is associated with lower trait motor impulsivity in healthy adults. 3053 58
