Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.3.1.177 (
BIS
)
957
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Typical (TPP) and atypical (
APP
) perfusion patterns (PP) may be seen in ictal SPECT of patients with temporal lobe epilepsy (TLE).
APP
may pose problem in the lateralization of the epileptogenic zone (EZ). We aimed to investigate predictive variables for the occurrence of TPP and
APP
. Fifty-one TLE patients were submitted to successful anterior-mesial temporal lobectomy. Univariate (UVA) and multivariate (MVA) analysis were performed upon clinical data, distribution of interictal spikes, and ictal chronology of seizures. From MVA, a final predictive model (FPM) was determined to better predict TPP and
APP
. Forty patients showed TPP (78.5%) and 11 patients
APP
(21.5%). Accuracy of ictal SPECT was higher in the unilateral (UIS) than in the bilateral (
BIS
) interictal spikes group (P = 0.05). FPM showed that patients exhibiting
BIS
, with shorter proportion of the electrographic seizure occurring after completion of tracer injection, and longer clinical than EEG seizure duration had more
APP
(P = 0.003). Generalized tonic-clonic seizures did not result in more
APP
. We concluded that analysis of ictal SPECT in TLE requires the knowledge of TPP and
APP
, the distribution of interictal spikes on temporal lobes and the ictal chronology of seizures.
BIS
showed that beyond a more complex epileptogenicity and seizure propagation, they may also lead to
APP
.
...
PMID:Ictal chronology and interictal spikes predict perfusion patterns in temporal lobe epilepsy: a multivariate study. 1515 7
