Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.3.1.177 (BIS)
 957 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Empathy is related to the natural human ability to understand emotions and feelings of others, where a sort of "resonance" mechanism between the observer and the observed permits a direct form of understanding. The present study explored four different measures related to empathic behavior in a social context: autonomic behavior (skin conductance--SCR, and heart rate--HR), personal response to empathic scale (BEES), approach-withdrawal attitudes (BIS/BAS), and verbal self-report measures. Participants were presented with different interpersonal scene types (cooperation, non-cooperation, conflict, indifference), and they were required to empathize with them. Different autonomic response patterns were found as a function of the interpersonal situations: SCR and HR increased in case of conflictual and non-cooperative situations. This result was confirmed by self-rating measures on empathy, since emotional involvement and valence attributed to the scenes varied in concomitance with psychophysiological parameters. Third, high and low BEES subjects showed different empathic behavior: high empathic subjects were more responsive (on both self-report and autonomic response) to empathy-related situations than low empathic subjects. Finally, BIS and BAS attitudes demonstrated a significant relationship with both BEES and autonomic patterns: high BAS subjects were more responsive and empathic with positive, cooperative situations, whereas high BIS empathized with more negative, conflictual situations. The convergence of these multidimensional measures was discussed.
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PMID:Resonance mechanism in empathic behavior BEES, BIS/BAS and psychophysiological contribution. 2184 42

Background. Apathy and impulsivity in Parkinson disease (PD) are associated with clinically significant behavioral disorders. Aim. To explore the phenomenology, distribution, and clinical correlates of these two behaviors. Methods. In PD participants (n = 99) without dementia we explored the distribution of measures of motivation and impulsivity using univariate methods. We then undertook factor analysis to define specific underlying dimensions of apathy and impulsivity. Regression models were developed to determine the associated demographic and clinical features of the derived dimensions. Results. The factor analysis of apathy (AES-C) revealed a two-factor solution: "cognitive-behavior" and "social indifference". The factor analysis of impulsivity (BIS-11) revealed a five-factor solution: "inattention"; "impetuosity"; "personal security"; "planning"; and "future orientation". Apathy was significantly associated with: age, age of motor symptom onset (positive correlation), disease stage, motor symptom severity, and depression. Impulsivity was significantly associated with: age of motor symptom onset (negative correlation), gambling and anxiety scores, and motor complications. We observed an overlap of apathy and impulsivity in some participants. Conclusion. In PD, apathy and impulsivity have specific phenomenological profiles and are associated with particular clinical phenotypes. In spite of this, there is some overlap of behaviors which may suggests common aspects in the pathology underlying motivation and reward processes.
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PMID:An exploration of apathy and impulsivity in Parkinson disease. 2282 14