Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.3.1.177 (BIS)
 957 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The electrophysiological correlates of error processing were investigated in patients with borderline personality disorder (BPD) using event-related potentials (ERP). Twelve patients with BPD and 12 healthy controls were additionally rated with the Barratt impulsiveness scale (BIS-10). Participants performed a Go/Nogo task while a 64 channel EEG was recorded. Three ERP components were of special interest: error-related negativity (ERN)/error negativity (Ne), early error positivity (early Pe) reflecting automatic error processing, and the late Pe component which is thought to mirror the awareness of erroneous responses. We found smaller amplitudes of the ERN/Ne in patients with BPD compared to controls. Moreover, significant correlations with the BIS-10 non-planning sub-score could be demonstrated for both the entire group and the patient group. No between-group differences were observed for the early and late Pe components. ERP measures appear to be a suitable tool to study clinical time courses in BPD.
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PMID:Electrophysiological correlates of error processing in borderline personality disorder. 1628 50

Borderline personality disorder (BPD) has been related to a dysfunction of anterior cingulate cortex, amygdala, and prefrontal cortex and has been associated clinically with impulsivity, affective instability, and significant interpersonal distress. We examined 17 patients with BPD and 17 age-, sex-, and education matched control participants with no history of Axis I or II psychopathology using event-related potentials (ERPs). Participants performed a hybrid flanker-Go/Nogo task while multichannel EEG was recorded. Our study focused on two ERP components: the Nogo-N2 and the Nogo-P3, which have been discussed in the context of response inhibition and response conflict. ERPs were computed on correct Go trials (button press) and correct Nogo trials (no button press), separately. Groups did not differ with regard to the Nogo-N2. However, BPD patients showed reduced Nogo-P3 amplitudes. For the entire group (n = 34) we found a negative correlation with the Barratt Impulsiveness Scale (BIS-10) and Becks's depression inventory (BDI). The present study is the first to examine Nogo-N2 and Nogo-P3 in BPD and provides further evidence for impaired response inhibition in BPD patients.
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PMID:Response inhibition in borderline personality disorder: event-related potentials in a Go/Nogo task. 1788 23

The amplitudes of the N2 and P3 components of event-related potentials (ERPs) may be influenced by personality traits such as impulsivity, and male/female differences may also have an effect. However, few studies have assessed the interaction between personality traits and the sex of the subject in these components. Therefore, in this study we evaluated sex differences in the amplitudes of the N2 and P3 ERP components during a continuous performance task, and their relation to impulse control. Twenty-seven healthy participants were asked to perform an AX-type continuous performance task, also known as a Go/Nogo task, during electroencephalographic recording. Participants then completed the Barratt impulsiveness scale (version 11; BIS-11), and the effortful control (EC) scale to self-report personality measures related to impulse control. We found that in the Nogo condition, males showed significantly larger N2 amplitudes than females in the frontal area. Interestingly, Nogo-N2 amplitudes were positively correlated with BIS-attentional subscale scores, but were negatively correlated with EC-attentional subscale scores, and both correlations were observed only in males. These results suggest that attentional aspects of impulse control modulate Nogo-N2 amplitude only in males. This modulatory effect may be related to a sex-specific inhibitory control mechanism acting during early stimulus evaluation.
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PMID:Sex differences in neurophysiological responses are modulated by attentional aspects of impulse control. 2647 54