Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.3.1.109 (AST)
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Human Gene/Protein
spliceosome associated protein 12.4
VCX protein 12.4
transducin-like enhancer protein 12.4
Ferritin light polypeptide 12.4
LRFT 12.4
AST 12.3
LC27 11.8
Cell death activator 11.4
actin, alpha 2, smooth muscle, aorta 10.8
enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase 10.4
GGT 2 10.4
GGT 10.0
GGT6 10.0
Ribosomal protein S27a 10.0
RRP2 10.0
mitochondrial solute carrier protein 10.0
ALP 10.0
aspartate aminotransferase 1 9.8
Insulin-like growth factor binding protein 1 9.8
Apolipoprotein O 9.6
glycerol-3-phosphate acyltransferase, mitochondrial 9.6
CD158i 9.2
stp2 9.2
ADPN 9.2
ALB 9.2
RRP1 9.0
CMTM2 9.0
SIKE 8.9
HMG-box transcription factor 1 8.8
PDRG1 8.8
kelch-like 8.6
INCLUDED 8.6
aryl sulfotransferase 8.5
LDH 8.5
IL28A 8.5
MRGPRD 8.4
N111 8.4
collagen, type I, alpha 1 8.4
Alpha-L-fucosidase 8.4
FAM3A 8.4
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Disease
Midzonal hepatic necrosis 12.4
Cholemic nephrosis 12.4
Cold Ischemia 10.8
Hyperprolinemia type II 10.8
Alcoholic liver damage 10.0
SPD2 9.8
Acute toxic hepatitis 9.6
SPD1 9.4
Jordan's anomaly 9.2
Ischemic hepatitis 8.6
MRX34 8.6
Necrobacillosis 8.6
Fulminant hepatitis 8.2
onychia 8.0
Dicrocoeliosis 8.0
Hepatotoxicity 8.0
Fasciola gigantica infection 7.9
EBV hepatitis 7.8
CMV hepatitis 7.7
Restrictive lung disease 7.6
Piscirickettsiosis 7.6
Bile duct cancer 7.6
UMS 7.5
XRN 7.5
Ehrlichia canis infection 7.5
Viral myocarditis 7.4
hypoglobulinemia 7.4
Intrahepatic cholestasis 7.3
alcoholic fatty liver 7.1
Vagina 7.1
peritonsillitis 7.1
Hb SC disease 7.1
Sphincter of Oddi dysfunction 7.1
Giant cell hepatitis 7.1
liver fibrosis 7.0
Retained placenta 7.0
Acute renal insufficiency 7.0
Cholestatic liver disease 6.9
Congo hemorrhagic fever 6.9
acute alcoholic hepatitis 6.9
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Symptom
liver pain 9.4
jaundice of the skin 9.4
ECG signs of myocardial ischemia 8.2
Limb weakness 8.2
rib pain 7.9
breast hyperplasia 7.2
sinus congestion 7.0
Flu-like symptoms 6.6
Kayser-Fleischer ring 6.1
frequent urination 5.9
hepatomegaly 5.9
gumma 5.9
lassitude 5.8
No adverse effect 5.0
abdominal cramps 4.9
arm weakness 4.8
ketonuria 4.8
hypoproteinemia 4.8
decreased appetite 4.8
pedal edema 4.6
inanition 4.6
oliguria 4.5
ACHE 4.5
periorbital edema 4.4
splenomegaly 4.3
nasal discharge 4.3
consciousness disturbance 4.3
non-productive cough 4.2
dark urine 4.2
myalgia 4.2
asthenia 4.0
meningism 4.0
right upper quadrant pain 3.9
epigastric pain 3.9
incoordination 3.9
hepatosplenomegaly 3.8
eye pain 3.8
anorexia 3.8
nausea 3.6
orthopnea 3.5
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Drug
Polygonatum rhizome 12.4
Plantago seed 12.4
Cholic Acid 11.4
Bupleurum root 9.2
Lifibrol 8.7
Tranexamic Acid 8.1
Darapladib 8.0
Gliquidone 7.6
Malotilate 7.6
Imagent 7.4
Gentian 7.4
Questran 7.2
Ilomastat 7.1
Toltrazuril 7.0
Sevelamer hydrochloride 6.7
Rokitamycin 6.7
Ioversol 6.5
Magnesium chloride 6.5
Nafamostat mesilate 6.4
NAH 6.4
Pregnyl 6.3
Esculin 6.3
Fennel 6.3
Tiopronin 6.3
Jujube 6.2
Trabectedin 6.2
Kayexalate 6.1
NLF 6.1
Lead acetate 6.1
Telbivudine 6.0
TAC 5.9
Treprostinil 5.9
Tirapazamine 5.9
Midodrine 5.9
Bosutinib 5.8
Senna 5.7
Senna 5.6
Liraglutide 5.6
Lipitor 5.6
Lipitor 5.6
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Enzyme
AST 12.4
EC 2.3.1.2 11.4
N-succinylglutamate 5-semialdehyde dehydrogenase 11.4
4-guanidinobutyraldehyde dehydrogenase 10.8
aryl sulfotransferase IV 10.6
aspartate aminotransferase 10.5
arginine racemase 10.4
SOAT 10.1
SADH 10.0
alanine aminotransferase 9.8
SGDS 9.8
BAST I 9.6
amine N-sulfotransferase 9.6
EC 2.3.2.1 8.6
glycocyamine kinase 8.4
gamma-glutamyl transpeptidase 8.3
acetylornithine aminotransferase 8.0
ornithine cyclodeaminase 7.9
EC 2.6.1.4 7.8
GMT 7.8
GBH 7.1
mannitol 1-phosphate dehydrogenase 7.0
ATase 7.0
arylsulfate sulfotransferase 7.0
MDH 6.6
MDH 6.5
LGT 6.5
GP-I 6.5
LDT 6.5
estrogen sulfotransferase 6.0
superoxide dismutase 6.0
PST 6.0
CYP8B1 5.9
MTD 5.7
GLO 5.7
catalase 5.6
aspartase 5.6
CYP7A1 5.6
creatine kinase 5.6
pyrroline-5-carboxylate dehydrogenase 5.5
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Compound
N,N-dimethylhydrazinecarboxamide 12.4
2,3-dibromo-2-butenoic acid 12.4
1-dotriacontanol 11.4
Usaramine 11.4
butyl palmitate 10.4
Murrayanine 10.4
PTGA 10.0
Astragaloside III 10.0
ALP 10.0
Cronolone 9.8
Indoxyl sulfate 9.8
Tetrachloride 9.4
Budlein A 9.2
1-bromopentane 8.9
Diphenyl ditelluride 8.9
Budlein A 8.9
Diphenyl ditelluride 8.9
Yangonin 8.8
Indoxyl 8.7
2,4-Di-tert-butylphenol 8.7
Glycyrrhizinic acid 8.7
Dihydrocoumarin 8.6
Yangonin 8.6
Piperlonguminine 8.6
Amprolium hydrochloride 8.6
2,4-Di-tert-butylphenol 8.6
Forsythiaside 8.4
D-Galactosamine 8.3
Dictamnine 8.3
benzyl selenocyanate 8.3
NAMS 8.1
Isovitexin 8.0
AFU 7.9
Fraxetin 7.9
Solanesol 7.8
Schisantherin A 7.8
Schisantherin A 7.8
Farrerol 7.8
1-bromo-2-chloroethane 7.7
Oxmetidine 7.7
more...