Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.3.1.109 (
AST
)
6,066
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The joint hepatotoxicity of CCl4 and CHCl3 or
TCE
in male CD rats following simultaneous oral administration has been investigated. Rats with chronic indwelling arterial cannulas were administered a single oral dose of CCl4 and CHCl3 or CCl4 and
TCE
in 5% Emulphor at doses of 0 to 700 mg/kg. Hepatotoxicity was evaluated by measuring the activity of
AST
, ALT, and SDH in plasma at 0, 3, 6, 12, 24, 36, 48, and 72 hr postgavage. Response data were analyzed for interaction using response surface methodology. CCl4 alone displayed dose-dependent toxicity.
TCE
demonstrated little evidence of hepatotoxicity. In combination, both CCl4/CHCl3 and CCl4/
TCE
displayed a synergistic (supraadditive) response for peak plasma enzyme activity.
...
PMID:Interactions of water contaminants. I. Plasma enzyme activity and response surface methodology following gavage administration of CCl4 and CHCl3 or TCE singly and in combination in the rat. 234 Sep 78
Trichloroethylene
(
TCE
) induced
TCE
hypersensitivity syndrome which makes immune injuries in multi-system. The multiple organ damage included skin, liver, kidney and so on. The main manifestations of liver injuries were apoptosis and edema of hepatocytes. In our previous research, we found the activation of Kupffer cells (KCs) which increased IL-6 can aggravate liver cell apoptosis in
TCE
sensitized mice. However, the mechanism of IL-6 in liver damages induced by
TCE
was not clear. This study explored the function of IL-6/STAT3 signal pathway on the
TCE
induced apoptosis of liver cell. We established a
TCE
sensitized BALB/c mouse model with a KCs inhibitor GdCl
3
, we found that the expressions of ALT and
AST
in
TCE
sensitization positive mice were higher than other mice, and the expressions of apoptosis-related proteins were up-regulated in
TCE
sensitization positive mice, GdCl
3
could alleviate this process. Meanwhile, GdCl
3
could significantly decrease the expressions of IL-6/STAT3 proteins. All in all, the activation of KCs can increase the expression of IL-6, IL-6R and phosphorylate STAT3, induces hepatocyte apoptosis, and participates in immunity damage of liver which induced by
TCE
.
...
PMID:Kupffer cell depletion attenuates IL-6/STAT3 mediates hepatocyte apoptosis in immunological liver injury of trichloroethylene sensitized mice. 3282 9
