Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.3.1.109 (
AST
)
6,066
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Macromolecular aspartate aminotransferase (L-aspartate: 2-oxoglutarate aminotransferase EC 2.6.1.1,
AST
) was found in the serum of a patient with benign hypertension. The serum total
AST
and mitochondrial
AST
(mAST) activities were proportionately higher. The abnormal
AST
was found to be a macromolecular complex composed of mAST and immunoglobulin G of the kappa-lambda type. The dissociated IgG from the complex was shown to combine with human and rat mAST, but not with cytosolic
AST
of both species. Molecular mass of the macromolecular
AST
was estimated to be 360,000 Da. These results indicate that the complex may consist of one IgG molecule associated with two mAST molecules. By the method of
papain
digestion the binding site of immunoglobulin in the complex appeared to be located in the Fab portion of the IgG molecule. This finding strongly suggests that the
AST
-immunoglobulin complex is a specific antigen-antibody complex.
...
PMID:Mitochondrial aspartate aminotransferase linked to immunoglobulin G of the kappa-lambda type: report of a case. 309 51
